The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Universal architecture of bacterial chemoreceptor arrays
Open accessAbstract
Chemoreceptors are key components of the high-performance signal transduction system that controls bacterial chemotaxis. Chemoreceptors are typically localized in a cluster at the cell pole, where interactions among the receptors in the cluster are thought to contribute to the high sensitivity, wide dynamic range, and precise adaptation of the signaling system. Previous structural and genomic studies have produced conflicting models, however, for the arrangement of the chemoreceptors in the clusters. Using whole-cell electron cryo-tomography, here we show that chemoreceptors of different classes and in many different species representing several major bacterial phyla are all arranged into a highly conserved, 12-nm hexagonal array consistent with the proposed “trimer of dimers” organization. The various observed lengths of the receptors confirm current models for the methylation, flexible bundle, signaling, and linker sub-domains in vivo. Our results suggest that the basic mechanism and function of receptor clustering is universal among bacterial species and was thus conserved during evolution.
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Cites
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The Pfam protein families database
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Bacterial chemoreceptors: high-performance signaling in networked arrays
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Receptor clustering as a cellular mechanism to control sensitivity
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Receptor sensitivity in bacterial chemotaxis
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Cited by
Signal processing in complex chemotaxis pathways
Porter, S. L., Wadhams, G. H., & Armitage, J. P. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2505 · Cited by 465
Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update
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Roberts, E., Stone, J. E., & Luthey‐Schulten, Z. (2013) · Journal of Computational Chemistry · doi:10.1002/jcc.23130 · Cited by 117
Tocheva, E. I., Matson, E. G., Morris, D. M., Moussavi, F., Leadbetter, J. R., & Jensen, G. J. (2011) · Cell · doi:10.1016/j.cell.2011.07.029 · Cited by 103
Self-citationMultiple ParA/MinD ATPases coordinate the positioning of disparate cargos in a bacterial cell
Pulianmackal, L. T., Limcaoco, J. M. I., Ravi, K., Yang, S., Zhang, J., Tran, M. K., Ghalmi, M., O’Meara, M. J., & Vecchiarelli, A. G. (2023) · Nature Communications · doi:10.1038/s41467-023-39019-x · Cited by 24
Metadata
- Authors
- Briegel, A., Ortega, D. R., Tocheva, E. I., Wuichet, K., Li, Z., Chen, S., Müller, A., Iancu, C. V., Murphy, G. E., Dobro, M. J., Zhulin, I. B., & Jensen, G. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-10-06
- Volume
- 106
- Issue
- 40
- Pages
- 17181-17186
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2137365831
- Cited by
- 326
- References
- 41
- FWCI
- 14.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Briegel, A., Ortega, D. R., Tocheva, E. I., Wuichet, K., Li, Z., Chen, S., Müller, A., Iancu, C. V., Murphy, G. E., Dobro, M. J., Zhulin, I. B., & Jensen, G. J. (2009). Universal architecture of bacterial chemoreceptor arrays. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0905181106
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
