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Distinct opioid circuits determine the palatability and the desirability of rewarding events
Open accessAbstract
It generally is assumed that a common neural substrate mediates both the palatability and the reward value of nutritive events. However, recent evidence suggests this assumption may not be true. Whereas opioid circuitry in both the nucleus accumbens and ventral pallidum has been reported to mediate taste-reactivity responses to palatable events, the assignment of reward or inventive value to goal-directed actions has been found to involve the basolateral amygdala. Here we found that, in rats, the neural processes mediating palatability and incentive value are indeed dissociable. Naloxone infused into either the ventral pallidum or nucleus accumbens shell blocked the increase in sucrose palatability induced by an increase in food deprivation without affecting the performance of sucrose-related actions. Conversely, naloxone infused into the basolateral amygdala blocked food deprivation-induced changes in sucrose-related actions without affecting sucrose palatability. This double dissociation of opioid-mediated changes in palatability and incentive value suggests that the role of endogenous opioids in reward processing does not depend on a single neural circuit. Rather, changes in palatability and in the incentive value assigned to rewarding events seem to be mediated by distinct neural processes.
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“For practical reasons, this research has focused on the amygdala’s role in signaling decreases in food value, but it probably signals increases in value, as well (84).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [84]
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“Instead, such responses are altered by blockage or stimulation of Nacc opioid receptors [44,49]”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [49]
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“suggesting that dissociable neurobiological substrates in the VS mediate motivational and hedonic processes.”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [49]
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Metadata
- Authors
- Wassum, K. M., Ostlund, S. B., Maidment, N. T., & Balleine, B. W.
- Affiliations
- University of California, Los Angeles (US)
- The University of Sydney (AU)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-07-28
- Volume
- 106
- Issue
- 30
- Pages
- 12512-12517
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2718390
- OpenAlex
- W2025466447
- Cited by
- 182
- References
- 41
- Citations by year
- 2026: 4 · 2025: 15 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 12 · 2020: 10 · 2019: 18 · 2018: 5 · 2017: 10 · 2016: 15 · 2015: 13 · 2014: 10 · 2013: 11 · 2012: 21
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R29MH056446, MH56446, R01MH056446, T32MH017140)
- National Institute on Drug Abuse (P50DA005010, DA05010, DA-09359, R01DA009359)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- endogenous opioids, palatability, incentive value, reward processing, nucleus accumbens shell, ventral pallidum, basolateral amygdala, food deprivation, sucrose, taste reactivity, naloxone, double dissociation, neural circuits
- MeSH terms
- Animals, Feeding Behavior, Food Deprivation, Food Preferences, Globus Pallidus, Male, Naloxone, Narcotic Antagonists, Neural Pathways, Nucleus Accumbens, Receptors, Opioid, Reward, Rats, Long-Evans, Rats
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