The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Distinct opioid circuits determine the palatability and the desirability of rewarding events
Open accessAbstract
It generally is assumed that a common neural substrate mediates both the palatability and the reward value of nutritive events. However, recent evidence suggests this assumption may not be true. Whereas opioid circuitry in both the nucleus accumbens and ventral pallidum has been reported to mediate taste-reactivity responses to palatable events, the assignment of reward or inventive value to goal-directed actions has been found to involve the basolateral amygdala. Here we found that, in rats, the neural processes mediating palatability and incentive value are indeed dissociable. Naloxone infused into either the ventral pallidum or nucleus accumbens shell blocked the increase in sucrose palatability induced by an increase in food deprivation without affecting the performance of sucrose-related actions. Conversely, naloxone infused into the basolateral amygdala blocked food deprivation-induced changes in sucrose-related actions without affecting sucrose palatability. This double dissociation of opioid-mediated changes in palatability and incentive value suggests that the role of endogenous opioids in reward processing does not depend on a single neural circuit. Rather, changes in palatability and in the incentive value assigned to rewarding events seem to be mediated by distinct neural processes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For practical reasons, this research has focused on the amygdala’s role in signaling decreases in food value, but it probably signals increases in value, as well (84).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [84]
In the citing paper
“Instead, such responses are altered by blockage or stimulation of Nacc opioid receptors [44,49]”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [49]
In the citing paper
“suggesting that dissociable neurobiological substrates in the VS mediate motivational and hedonic processes.”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bayesian t tests for accepting and rejecting the null hypothesis
Rouder, J. N., Speckman, P. L., Sun, D., Morey, R. D., & Iverson, G. (2009) · Psychonomic Bulletin & Review · doi:10.3758/pbr.16.2.225 · Cited by 3,688
The somatic marker hypothesis and the possible functions of the prefrontal cortex
Damasio, A. R. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0125 · Cited by 2,847 · cited 4×
“Pharmacol Biochem Behav 46(3):745–749.”
BackgroundResultInfluentialEmotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129
Food reward: brain substrates of wanting and liking
Berridge, K. C. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00033-b · Cited by 1,901
Goal-directed instrumental action: contingency and incentive learning and their cortical substrates
Balleine, B. W., & Dickinson, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00033-1 · Cited by 1,541
Self-citationAffective consciousness: core emotional feelings in animals and humans.
Panksepp, J. (2005) · Consciousness and Cognition · doi:10.1016/j.concog.2004.10.004 · Cited by 1,217
Motivational control of goal-directed action
Dickinson, A., & Balleine, B. (1994) · Animal Learning & Behavior · doi:10.3758/bf03199951 · Cited by 995
Self-citationKelley, A. E. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.015 · Cited by 942
Reward, Motivation, and Reinforcement Learning
Dayan, P., & Balleine, B. W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00963-7 · Cited by 855
Self-citationPeciña, S., & Berridge, K. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2329-05.2005 · Cited by 671
Cited by
Sorted by citations
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358
Balleine, B. W., & O'Doherty, J. P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.131 · Cited by 1,775
Self-citationReward, dopamine and the control of food intake: implications for obesity
Volkow, N. D., Wang, G.-J., & Baler, R. D. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.001 · Cited by 1,400
The neurobiology of anhedonia and other reward-related deficits
Der-Avakian, A., & Markou, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.005 · Cited by 1,130
Reward mechanisms in obesity: new insights and future directions
Kenny, P. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.016 · Cited by 748
Disentangling pleasure from incentive salience and learning signals in brain reward circuitry
Smith, K. S., Berridge, K. C., & Aldridge, J. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101920108 · Cited by 464
Morrison, S. E., & Salzman, C. D. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.02.007 · Cited by 354
Contributions of the striatum to learning, motivation, and performance: an associative account
Liljeholm, M., & O’Doherty, J. P. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.07.007 · Cited by 317
The basolateral amygdala in reward learning and addiction
Wassum, K. M., & Izquierdo, A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.017 · Cited by 306
Self-citationThe role of dopamine in the accumbens core in the expression of Pavlovian‐conditioned responses
Saunders, B. T., & Robinson, T. E. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08217.x · Cited by 325
Castro, D. C., & Bruchas, M. R. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.003 · Cited by 306
Regulation of dietary choice by the decision-making circuitry
Rangel, A. (2013) · Nature Neuroscience · doi:10.1038/nn.3561 · Cited by 263
Thomsen, K. R., Whybrow, P. C., & Kringelbach, M. L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00049 · Cited by 256
Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala
Murray, E. A., Wise, S. P., & Drevets, W. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.041 · Cited by 208
Frascella, J., Potenza, M. N., Brown, L. L., & Childress, A. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05420.x · Cited by 203
Historical Review: Opiate Addiction and Opioid Receptors
Wang, S.-C. (2018) · Cell Transplantation · doi:10.1177/0963689718811060 · Cited by 188
Amygdala Central Nucleus Interacts with Dorsolateral Striatum to Regulate the Acquisition of Habits
Lingawi, N. W., & Balleine, B. W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4806-11.2012 · Cited by 172
Self-citationBasolateral amygdala to orbitofrontal cortex projections enable cue-triggered reward expectations
Lichtenberg, N. T., Pennington, Z. T., Holley, S. M., Greenfield, V. Y., Cepeda, C., Levine, M. S., & Wassum, K. M. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.0486-17.2017 · Cited by 171
Self-citationWhat and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex
Mahler, S. V., & Berridge, K. C. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2588-6 · Cited by 170
Individual variation in resisting temptation: Implications for addiction
Saunders, B. T., & Robinson, T. E. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.008 · Cited by 177
An Orexin Hotspot in Ventral Pallidum Amplifies Hedonic ‘Liking’ for Sweetness
Ho, C., & Berridge, K. C. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.62 · Cited by 160
Baskin-sommers, A. R., & Foti, D. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.01.011 · Cited by 173
Opioid Addiction, Genetic Susceptibility, and Medical Treatments: A Review
Wang, S.-C., Chen, Y., Lee, C.-H., & Cheng, C.-M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174294 · Cited by 156
Cui, Y., Ostlund, S. B., James, A. S., Park, C. S., Ge, W., Roberts, K. W., Mittal, N., Murphy, N. P., Cepeda, C., Kieffer, B. L., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3622 · Cited by 147
Self-citationParkes, S. L., & Balleine, B. W. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5071-12.2013 · Cited by 136
Self-citationDistinct cortical–amygdala projections drive reward value encoding and retrieval
Malvaez, M., Shieh, C., Murphy, M. D., Greenfield, V. Y., & Wassum, K. M. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0374-7 · Cited by 130
Self-citationWassum, K. M., Ostlund, S. B., Balleine, B. W., & Maidment, N. T. (2011) · Learning & Memory · doi:10.1101/lm.2229311 · Cited by 144
Self-citationThe multiple facets of opioid receptor function: implications for addiction
Lutz, P.-É., & Kieffer, B. L. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.005 · Cited by 129
Connectivity characterization of the mouse basolateral amygdalar complex
Hintiryan, H., Bowman, I., Johnson, D. L., Korobkova, L., Zhu, M., Khanjani, N., Gou, L., Gao, L., Yamashita, S., Bienkowski, M. S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22915-5 · Cited by 127
The Origins and Organization of Vertebrate Pavlovian ConditioningPreprint
Fanselow, M., & Wassum, K. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021717 · Cited by 132
Self-citationParkes, S. L., Ravassard, P., Cerpa, J.-C., Wolff, M., Ferreira, G., & Coutureau, É. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx132 · Cited by 126
The impact of stress in decision making in the context of uncertainty
Morgado, P. F., Sousa, N., & Cerqueira, J. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23521 · Cited by 134
Dynamic mesolimbic dopamine signaling during action sequence learning and expectation violation
Collins, A. L., Greenfield, V. Y., Bye, J. K., Linker, K. E., Wang, A. S., & Wassum, K. M. (2016) · Scientific Reports · doi:10.1038/srep20231 · Cited by 125
Self-citationThe role of the opioid system in decision making and cognitive control: a review
van Steenbergen, H., Eikemo, M., & Leknes, S. (2019) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-019-00710-6 · Cited by 118
Hipólito, L., Wilson‐Poe, A. R., Campos‐Jurado, Y., Zhong, E., González-Romero, J. L., Virag, L., Whittington, R. A., Comer, S. D., Carlton, S. M., Walker, B. M., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1053-15.2015 · Cited by 114
Ho, C., & Berridge, K. C. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12720 · Cited by 124
Giuliano, C., Robbins, T. W., Nathan, P. J., Bullmore, E. T., & Everitt, B. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.128 · Cited by 111
Mai, B., Sommer, S., & Hauber, W. (2011) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-011-0068-4 · Cited by 108
Hedonic and motivational roles of opioids in food reward: Implications for overeating disorders
Peciña, S., & Smith, K. S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.05.016 · Cited by 104
Nucleus Accumbens Cholinergic Interneurons Oppose Cue-Motivated Behavior
Collins, A. L., Aitken, T. J., Huang, I.-W., Shieh, C., Greenfield, V. Y., Monbouquette, H. G., Ostlund, S. B., & Wassum, K. M. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.014 · Cited by 110
Self-citationNucleus Accumbens Acetylcholine Receptors Modulate Dopamine and Motivation
Collins, A. L., Aitken, T. J., Greenfield, V. Y., Ostlund, S. B., & Wassum, K. M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.81 · Cited by 97
Self-citationHindbrain Double-Negative Feedback Mediates Palatability-Guided Food and Water Consumption
Gong, R., Xu, S., Hermundstad, A. M., Yu, Y., & Sternson, S. M. (2020) · Cell · doi:10.1016/j.cell.2020.07.031 · Cited by 81
Laurent, V., Leung, B. K., Maidment, N. T., & Balleine, B. W. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4688-11.2012 · Cited by 85
Self-citationAmygdala-cortical collaboration in reward learning and decision making
Wassum, K. M. (2022) · eLife · doi:10.7554/elife.80926 · Cited by 88
Self-citationHedonic eating is controlled by dopamine neurons that oppose GLP-1R satiety
Zhu, Z., Gong, R., Rodriguez, V., Quach, K. T., Chen, X., & Sternson, S. M. (2025) · Science · doi:10.1126/science.adt0773 · Cited by 85
Transient Extracellular Glutamate Events in the Basolateral Amygdala Track Reward-Seeking Actions
Wassum, K. M., Tolosa, V., Tseng, T. T. ‐., Balleine, B. W., Monbouquette, H. G., & Maidment, N. T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5780-11.2012 · Cited by 74
Self-citationClouard, C., Meunier‐Salaün, M. C., & Val‐Laillet, D. (2011) · animal · doi:10.1017/s1751731111001315 · Cited by 72
The role of opioid processes in reward and decision-making
Laurent, V., Morse, A. K., & Balleine, B. W. (2015) · British Journal of Pharmacology · doi:10.1111/bph.12818 · Cited by 64
Self-citationWassum, K. M., Cely, I., Balleine, B. W., & Maidment, N. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3102-10.2011 · Cited by 67
Self-citationMidbrain response to milkshake correlates with ad libitum milkshake intake in the absence of hunger
Nolan-Poupart, S., Veldhuizen, M. G., Geha, P., & Small, D. M. (2012) · Appetite · doi:10.1016/j.appet.2012.09.032 · Cited by 63
Endogenous opiates and behavior: 2009
Bodnar, R. J. (2010) · Peptides · doi:10.1016/j.peptides.2010.09.016 · Cited by 61
Mitra, A., Gosnell, B. A., Schiöth, H. B., Grace, M. K., Klockars, A., Olszewski, P. K., & Levine, A. S. (2010) · Peptides · doi:10.1016/j.peptides.2010.04.005 · Cited by 61
Murphy, A., Taylor, E., & Elliott, R. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00101 · Cited by 69
Lichtenberg, N. T., Sepe-Forrest, L., Pennington, Z. T., Lamparelli, A. C., Greenfield, V. Y., & Wassum, K. M. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0901-21.2021 · Cited by 58
Self-citationNaneix, F., Peters, K. Z., & McCutcheon, J. E. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.10.036 · Cited by 55
Ostlund, S. B., Kosheleff, A. R., Maidment, N. T., & Murphy, N. P. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3077-x · Cited by 51
Self-citationOpiates, overeating and obesity: a psychogenetic analysis
Davis, C. A., Zai, C. C. H., Levitan, R. D., Kaplan, A. S., Carter, J. C., Reid‐Westoby, C., Curtis, C., Wight, K., & Kennedy, J. L. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.276 · Cited by 51
Reassessing wanting and liking in the study of mesolimbic influence on food intake
Nicola, S. M. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00234.2016 · Cited by 52
Function and Mechanism of Myelin Regulation in Alcohol Abuse and Alcoholism
Rice, J., & Gu, C. (2019) · BioEssays · doi:10.1002/bies.201800255 · Cited by 49
Mood and metabolism: Anhedonia as a clinical target in Type 2 diabetes
Carter, J., & Swardfager, W. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.002 · Cited by 56
Ashok, A. H., Myers, J., Marques, T. R., Rabiner, E. A., & Howes, O. D. (2019) · Nature Communications · doi:10.1038/s41467-019-12366-4 · Cited by 47
The effect of high-fat diet consumption on appetitive instrumental behavior in rats
Tantot, F., Parkes, S. L., Marchand, A. R., Boitard, C., Naneix, F., Layé, S., Trifilieff, P., Coutureau, É., & Ferreira, G. (2016) · Appetite · doi:10.1016/j.appet.2016.10.001 · Cited by 49
Orbital frontal cortex updates state-induced value change for decision-making
Baltz, E. T., Yalcinbas, E. A., Renteria, R., & Gremel, C. M. (2018) · eLife · doi:10.7554/elife.35988 · Cited by 47
Disruption of endogenous opioid activity during instrumental learning enhances habit acquisition
Wassum, K. M., Cely, I. C., Maidment, N. T., & Balleine, B. W. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.06.071 · Cited by 46
Self-citationWest, E. A., Forcelli, P. A., Murnen, A. T., McCue, D. L., Gale, K., & Málková, L. (2012) · Behavioral Neuroscience · doi:10.1037/a0029080 · Cited by 45
Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability
Yang, A. K., Mendoza, J. A., Lafferty, C. K., Lacroix, F., & Britt, J. P. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.007 · Cited by 43
Sutton, L. P., Ostrovskaya, O. I., Dao, M. T., Xie, K., Orlandi, C., Smith, R. G., Wee, S., & Martemyanov, K. A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.026 · Cited by 43
Parker, K. E., Johns, H. W., Floros, T. G., & Will, M. J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.11.014 · Cited by 43
Meier, I. M., Eikemo, M., & Leknes, S. (2021) · Current Addiction Reports · doi:10.1007/s40429-021-00366-8 · Cited by 49
Enduring disruption of reward and stress circuit activities by early-life adversity in male rats
Levis, S. C., Birnie, M. T., Bolton, J. L., Perrone, C. R., Montesinos, J. S., Baram, T. Z., & Mahler, S. V. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01988-w · Cited by 44
Valence Encoding Signals in the Human Amygdala and the Willingness to Eat
Tiedemann, L. J., Alink, A., Beck, J., Büchel, C., & Brassen, S. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2382-19.2020 · Cited by 43
Naneix, F., Darlot, F., Coutureau, É., & Cador, M. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13149 · Cited by 43
Richard, J. M., & Fields, H. L. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.010 · Cited by 39
Bodnar, R. J. (2019) · Peptides · doi:10.1016/j.peptides.2019.04.008 · Cited by 40
Balleine, B. W., Morris, R. W., & Leung, B. K. (2014) · Brain Research · doi:10.1016/j.brainres.2014.12.023 · Cited by 41
Self-citationSucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain
Winterdahl, M., Noer, O., Orłowski, D., Schacht, A. C., Jakobsen, S., Alstrup, A. K. O., GJEDDE, A. H., & Landau, A. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-53430-9 · Cited by 43
Smith, C. J. W., Wilkins, K. B., Li, S. J., Tulimieri, M. T., & Veenema, A. H. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.12.017 · Cited by 37
Sex-specific enhancement of palatability-driven feeding in adolescent rats
Marshall, A. T., Liu, A. T., Murphy, N. P., Maidment, N. T., & Ostlund, S. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180907 · Cited by 33
Self-citationLøseth, G. E., Eikemo, M., & Leknes, S. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz022 · Cited by 28
The role of the nucleus accumbens and ventral pallidum in feeding and obesity
Gendelis, S., Inbar, D., & Kupchik, Y. M. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110394 · Cited by 30
Liu, C. M., Hsu, T. M., Suarez, A. N., Subramanian, K. S., Fatemi, R. A., Cortella, A. M., Noble, E. E., Roitman, M. F., & Kanoski, S. E. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104855 · Cited by 29
Role of the striatal dopamine, GABA and opioid systems in mediating feeding and fat intake
Joshi, A., Schott, M., la Fleur, S. E., & Barrot, M. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104726 · Cited by 28
Amygdala mu‐opioid receptors mediate the motivating influence of cue‐triggered reward expectations
Lichtenberg, N. T., & Wassum, K. M. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13477 · Cited by 29
Self-citationReview of Orbitofrontal Cortex in Alcohol Dependence: A Disrupted Cognitive Map?
Shields, C. N., & Gremel, C. M. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14441 · Cited by 26
Parker, K. E., McCall, J. G., & Will, M. J. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.08.008 · Cited by 26
Kareken, D. A., Džemidžić, M., Oberlin, B. G., & Eiler, W. J. A. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12194 · Cited by 26
Effects of obesogenic diets on learning and habitual responding
Corbit, L. H. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.02.010 · Cited by 22
Wong, S., Balleine, B. W., & Kumfor, F. (2018) · Brain · doi:10.1093/brain/awy123 · Cited by 22
Self-citationSensation, Incentive Learning, and the Motivational Control of Goal-Directed Action
Gottfried, J. A. (2011) · CRC Press eBooks · doi:10.1201/b10776-21 · Cited by 21
Insights into the Neurobiology of Craving in Opioid Use Disorder
Lueptow, L. M., Shashkova, E., Miller, M. G., Evans, C. J., & Cahill, C. M. (2020) · Current anesthesiology reports · doi:10.1007/s40140-020-00420-7 · Cited by 20
Zhang, J., Lu, Y., Jia, M., Bai, Y., Sun, L., Dong, Z., Tian, W., Yin, F., Wei, S., & Wang, Y. (2023) · iScience · doi:10.1016/j.isci.2023.107536 · Cited by 19
Simón, M. J., García, R., & Puerto, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.029 · Cited by 19
Food Addiction Spectrum: A Theoretical Model from Normality to Eating and Overeating Disorders
Piccinni, A., Marazziti, D., Vanelli, F., Franceschini, C., Baroni, S., Costanzo, D., Cremone, I. M., Veltri, A., & Dell’Osso, L. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867322666150227153015 · Cited by 22
Björk, K., Tronci, V., Thorsell, A., Tanda, G., Hirth, N., Heilig, M. A., Hansson, A. C., & Sommer, W. H. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3166-x · Cited by 19
Transforming experiences: Neurobiology of memory updating/editing
Osorio‐Gómez, D., Miranda, M. I., Guzmán-Ramos, K. R., & Bermúdez‐Rattoni, F. (2023) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2023.1103770 · Cited by 20
Bodnar, R. J. (2015) · Peptides · doi:10.1016/j.peptides.2015.03.019 · Cited by 18
Intermittent feeding alters sensitivity to changes in reward value
Parkes, S. L., Furlong, T. M., Black, A. D., & Balleine, B. W. (2017) · Appetite · doi:10.1016/j.appet.2017.02.009 · Cited by 18
Self-citationExtinction and the associative structure of heterogeneous instrumental chains
Thrailkill, E. A., & Bouton, M. E. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.06.005 · Cited by 17
Inflated reward value in early opiate withdrawal
Wassum, K. M., Greenfield, V. Y., Linker, K. E., Maidment, N. T., & Ostlund, S. B. (2014) · Addiction Biology · doi:10.1111/adb.12172 · Cited by 18
Self-citationOpioid Regulation of Social Homeostasis: Connecting Loneliness to Addiction
Løseth, G. E., Eikemo, M., & Leknes, S. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.11.011 · Cited by 16
Metadata
- Authors
- Wassum, K. M., Ostlund, S. B., Maidment, N. T., & Balleine, B. W.
- Affiliations
- University of California, Los Angeles (US)
- The University of Sydney (AU)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-07-28
- Volume
- 106
- Issue
- 30
- Pages
- 12512-12517
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2718390
- OpenAlex
- W2025466447
- Cited by
- 182
- References
- 41
- Citations by year
- 2026: 4 · 2025: 15 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 12 · 2020: 10 · 2019: 18 · 2018: 5 · 2017: 10 · 2016: 15 · 2015: 13 · 2014: 10 · 2013: 11 · 2012: 21
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R29MH056446, MH56446, R01MH056446, T32MH017140)
- National Institute on Drug Abuse (P50DA005010, DA05010, DA-09359, R01DA009359)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- endogenous opioids, palatability, incentive value, reward processing, nucleus accumbens shell, ventral pallidum, basolateral amygdala, food deprivation, sucrose, taste reactivity, naloxone, double dissociation, neural circuits
- MeSH terms
- Animals, Feeding Behavior, Food Deprivation, Food Preferences, Globus Pallidus, Male, Naloxone, Narcotic Antagonists, Neural Pathways, Nucleus Accumbens, Receptors, Opioid, Reward, Rats, Long-Evans, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
