Evolution amplified processing with temporally dispersed slow neuronal connectivity in primates.
Open accessAbstract
The corpus callosum (CC) provides the main route of communication between the 2 hemispheres of the brain. In monkeys, chimpanzees, and humans, callosal axons of distinct size interconnect functionally different cortical areas. Thinner axons in the genu and in the posterior body of the CC interconnect the prefrontal and parietal areas, respectively, and thicker axons in the midbody and in the splenium interconnect primary motor, somatosensory, and visual areas. At all locations, axon diameter, and hence its conduction velocity, increases slightly in the chimpanzee compared with the macaque because of an increased number of large axons but not between the chimpanzee and man. This, together with the longer connections in larger brains, doubles the expected conduction delays between the hemispheres, from macaque to man, and amplifies their range about 3-fold. These changes can have several consequences for cortical dynamics, particularly on the cycle of interhemispheric oscillators.
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The latency difference was considerably less than the hypothesized 10+ ms required for transcallosal transmission.
“The latency difference was considerably less than the hypothesized latency (10+ ms) required for transcallosal transmission (Caminiti et al., 2009).”
From Factors influencing the latency of simple reaction time (2015) · cites this paper as Caminiti et al., 2009
The Results (page unavailable) report estimated total callosal conduction delays of 16–24 ms for human visual areas, supporting a latency on the order of 10+ ms. But the paper does not establish 10 ms as a minimum required for all transcallosal transmission; it reports rhesus-monkey interhemispheric delays as low as 2.6 ms. The citing authors’ measured latency difference is not a finding attributed to this source. (LLM, conf=0.86)
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Factors influencing the latency of simple reaction time
Woods, D. L., Wyma, J. M., Yund, E. W., Herron, T. J., & Reed, B. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00131 · Cited by 336 · see citing works
“The latency difference was considerably less than the hypothesized latency (10+ ms) required for transcallosal transmission (Caminiti et al., 2009).”
BackgroundLiewald, D., Miller, R., Logothetis, N., Wagner, H.-J., & Schüz, A. (2014) · Biological Cybernetics · doi:10.1007/s00422-014-0626-2 · Cited by 322 · see citing works
Kozai, T. D. Y., Li, X., Bodily, L. M., Caparosa, E. M., Zenonos, G. A., Carlisle, D. L., Friedlander, R. M., & Cui, X. T. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.08.006 · Cited by 136 · see citing works
Moon, J.-Y., Lee, U., Blain-Moraes, S., & Mashour, G. A. (2015) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004225 · Cited by 136 · see citing works
Cortico-spinal modularity in the parieto-frontal system: A new perspective on action control
Bufacchi, R. J., Battaglia-Mayer, A., Iannetti, G. D., & Caminiti, R. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102537 · Cited by 22 · see citing works
Self-citation
- Authors
- Caminiti, R., Ghaziri, H., Galuske, R., Hof, P. R., & Innocenti, G. M.
- Affiliations
- Sapienza University of Rome (IT)
- École Polytechnique Fédérale de Lausanne (CH)
- Technische Universität Darmstadt (DE)
- Icahn School of Medicine at Mount Sinai (US)
- Karolinska Institutet (SE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-11-17
- Volume
- 106
- Issue
- 46
- Pages
- 19551-19556
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2770441
- OpenAlex
- W2127800088
- Cited by
- 189
- References
- 1
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 7 · 2023: 11 · 2022: 13 · 2021: 11 · 2020: 15 · 2019: 13 · 2018: 17 · 2017: 15 · 2016: 15 · 2015: 14 · 2014: 5 · 2013: 12 · 2012: 11
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- corpus callosum, interhemispheric connectivity, axon diameter, conduction velocity, conduction delay, chimpanzees, macaque, human evolution, cortical dynamics, corpus callosum genu, splenium of corpus callosum, interhemispheric synchronization
- MeSH terms
- Animals, Axons, Pan troglodytes, Corpus Callosum, Biological Evolution, Humans, Macaca, Male, Neurons
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