The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
GluN2B subunit-containing NMDA receptor antagonists prevent Aβ-mediated synaptic plasticity disruption in vivo
Open accessAbstract
Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the use of memantine is the inhibition of NMDA receptor-dependent synaptic plasticity mechanisms believed to underlie certain forms of memory. Moreover, amyloid-β protein (Aβ) oligomers that are implicated in causing the cognitive deficits of AD potently inhibit this form of plasticity. Here we examined if subtype-preferring NMDA receptor antagonists could preferentially protect against the inhibition of NMDA receptor-dependent plasticity of excitatory synaptic transmission by Aβ in the hippocampus in vivo. Using doses that did not affect control plasticity, antagonists selective for NMDA receptors containing GluN2B but not other GluN2 subunits prevented Aβ 1–42 -mediated inhibition of plasticity. Evidence that the proinflammatory cytokine TNFα mediates this deleterious action of Aß was provided by the ability of TNFα antagonists to prevent Aβ 1–42 inhibition of plasticity and the abrogation of a similar disruptive effect of TNFα using a GluN2B-selective antagonist. Moreover, at nearby synapses that were resistant to the inhibitory effect of TNFα, Aβ 1–42 did not significantly affect plasticity. These findings suggest that preferentially targeting GluN2B subunit-containing NMDARs may provide an effective means of preventing cognitive deficits in early Alzheimer's disease.
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Self-citationDiffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
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Cited by
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
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Biochemistry of Amyloid -Protein and Amyloid Deposits in Alzheimer Disease
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Metadata
- Authors
- Hu, N.-W., Klyubin, I., Anwyl, R., & Rowan, M. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-12
- Volume
- 106
- Issue
- 48
- Pages
- 20504-20509
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2049801826
- Cited by
- 171
- References
- 17
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- green
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