Tumor Necrosis Factor-α Induces Neurotoxicity via Glutamate Release from Hemichannels of Activated Microglia in an Autocrine Manner

Microglia: a sensor for pathological events in the CNS

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Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

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Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism

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UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS

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The release and uptake of excitatory amino acids

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Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data

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Functional Hemichannels in Astrocytes: A Novel Mechanism of Glutamate Release

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Production of tumor necrosis factor-alpha by microglia and astrocytes in culture

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Inflammatory Neurodegeneration Mediated by Nitric Oxide from Activated Glia-Inhibiting Neuronal Respiration, Causing Glutamate Release and Excitotoxicity

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Inflammatory processes in amyotrophic lateral sclerosis

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IFN-γ production by antigen-presenting cells: mechanisms emerge

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Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria

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Microglial Phagocytosis of Fibrillar β-Amyloid through a β1Integrin-Dependent Mechanism

Koenigsknecht-Talboo, J., & Landreth, G. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2557-04.2004 · Cited by 444 · see citing works

Connexin-based gap junction hemichannels: Gating mechanisms

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TNFα potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NFκB inhibition

Zou, J., & Crews, F. T. (2005) · Brain Research · doi:10.1016/j.brainres.2004.11.014 · Cited by 410 · see citing works

Production and neuroprotective functions of fractalkine in the central nervous system.

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MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by γ-interferon

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An inflammatory review of Parkinson's disease

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Stimulation of Microglial Metabotropic Glutamate Receptor mGlu2 Triggers Tumor Necrosis Factor α-Induced Neurotoxicity in Concert with Microglial-Derived Fas Ligand

Taylor, D. L., Jones, F., Kubota, E. S. F. C. S., & Pocock, J. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4456-04.2005 · Cited by 308 · see citing works

Neuritic Beading Induced by Activated Microglia Is an Early Feature of Neuronal Dysfunction Toward Neuronal Death by Inhibition of Mitochondrial Respiration and Axonal Transport

Takeuchi, H., Mizuno, T., Zhang, G., Wang, J., Kawanokuchi, J., Kuno, R., & Suzumura, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413863200 · Cited by 285 · see citing works

Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons.

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Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function

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Intracellular calcium changes trigger connexin 32 hemichannel opening

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β-Amyloid-Stimulated Microglia Induce Neuron Death via Synergistic Stimulation of Tumor Necrosis Factor α and NMDA Receptors

Floden, A. M., Li, S., & Combs, C. K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4998-04.2005 · Cited by 246 · see citing works

Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-γ and tumor necrosis factor-α

Eugenín, E. A., Eckardt, D., Theis, M., Willecke, K., Bennett, M. V. L., & Sáez, J. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051634298 · Cited by 238 · see citing works

Microglia in diseases of the central nervous system

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Rates of utilization of glucose, glutamine and oleate and formation of end-products by mouse peritoneal macrophages in culture

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Autocrine activation of microglia by tumor necrosis factor-α

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A new concept in neurodegeneration: TNFα is a silencer of survival signals

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Dual effect of CD4 + CD25 + regulatory T cells in neurodegeneration: A dialogue with microglia

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The proposed role of glutamine in some cells of the immune system and speculative consequences for the whole animal

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Mitochondrial Localization of Mutant Superoxide Dismutase 1 Triggers Caspase-dependent Cell Death in a Cellular Model of Familial Amyotrophic Lateral Sclerosis*

Takeuchi, H., Kobayashi, Y., Ishigaki, S., Doyu, M., & Sobue, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209356200 · Cited by 154 · see citing works

Apoptotic Pathways Mobilized in Microglia and Neurones as a Consequence of Chromogranin A‐Induced Microglial Activation

Kingham, P. J., Cuzner, M. L., & Pocock, J. M. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730538.x · Cited by 141 · see citing works

Microglia: The Enemy Within?

Kempermann, G., & Neumann, H. (2003) · Science · doi:10.1126/science.1092864 · Cited by 139 · see citing works

System X_c⁻and Apolipoprotein E Expressed by Microglia Have Opposite Effects on the Neurotoxicity of Amyloid-β Peptide 1–40

Qin, S., Colin, C., Hinners, I., Gervais, A., Cheret, C., & Mallat, M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5186-05.2006 · Cited by 135 · see citing works

Protective autoimmunity against the enemy within: fighting glutamate toxicity

Schwartz, M. H. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00126-7 · Cited by 128 · see citing works

New Therapeutic Strategies and Drug Candidates for Neurodegenerative Diseases: p53 and TNF‐α Inhibitors, and GLP‐1 Receptor Agonists

Greig, N. H., Mattson, M. P., Perry, T., Chan, S. L., Giordano, T., Sambamurti, K., Rogers, J. T., Ovadia, H., & Lahiri, D. K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.018 · Cited by 98 · see citing works

The effect of microglia on embryonic dopaminergic neuronal survival in vitro: diffusible signals from neurons and glia change microglia from neurotoxic to neuroprotective

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Mechanisms Underlying Neuronal Death Induced by Chromogranin A-activated Microglia

Ciesielski-Treska, J., Ulrich, G., Chasserot‐Golaz, S., Zwiller, J., Revel, M., Aunis, D., & Bader, M. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009711200 · Cited by 80 · see citing works

Expression of cytokines during glial differentiation

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Tumor Necrosis Factor and Motoneuronal Degeneration: An Open Problem

Ghezzi, P., & Mennini, T. (2001) · NeuroImmunoModulation · doi:10.1159/000049024 · Cited by 60 · see citing works

Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulating factor

Suzumura, A., Sawada, M., & Marunouchi, T. (1996) · Brain Research · doi:10.1016/0006-8993(95)01535-3 · Cited by 56 · see citing works

Novel, non-antigen-specific therapeutic approaches to autoimmune/inflammatory diseases

Illei, G. G., & Lipsky, P. E. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00167-9 · Cited by 49 · see citing works

Microglia rules: insights into micoglial–neuronal signaling

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Glucose transporter proteins in brain: Delivery of glucose to neurons and glia

Vannucci, S. J., Maher, F., & Simpson, I. A. (1997) · Glia · doi:10.1002/(sici)1098-1136(199709)21:1

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · doi:10.1101/406140 · Cited by 2,225 · see citing works

Inflammatory process in Alzheimer's Disease

Meraz-Ríos, M. A., Toral-Rios, D., Franco-Bocanegra, D., Villeda-Hernández, J., & Campos-Peña, V. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00059 · Cited by 427 · see citing works

The P2X ₇ Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X ₇ R Pore

Monif, M., Reid, C. A., Powell, K. L., Smart, M. L., & Williams, D. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5512-08.2009 · Cited by 374 · see citing works

Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease

Rojo, L. E., Fernández, J. A., Maccioni, A. A., Jimenez, J. M., & Maccioni, R. B. (2008) · Archives of Medical Research · doi:10.1016/j.arcmed.2007.10.001 · Cited by 351 · see citing works

Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

González, H., Elgueta, D., Montoya, A., & Pacheco, R. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.07.012 · Cited by 352 · see citing works

Neuroinflammation: Modulation by flavonoids and mechanisms of action

Spencer, J. P. E., Vafeiadou, K., Williams, R. J., & Vauzour, D. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.016 · Cited by 315 · see citing works

Relationship between intracortical electrode design and chronic recording function

Karumbaiah, L., Saxena, T., Carlson, D., Patil, K., Patkar, R., Gaupp, E. A., Betancur, M., Stanley, G. B., Carin, L., & Bellamkonda, R. V. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.016 · Cited by 241 · see citing works

TNF-alpha-induced microglia activation requires miR-342: Impact on NF-kB signaling and neurotoxicity

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Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

Janelsins, M. C., Mastrangelo, M. A., Park, K. M., Sudol, K. L., Narrow, W. C., Oddo, S., LaFerla, F. M., Callahan, L. M., Federoff, H. J., & Bowers, W. J. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.080528 · Cited by 220 · see citing works

Retinal Macroglial Responses in Health and Disease

de Hoz, R., Rojas, B., Ramírez, A. I., Salazar, J. J., Gallego, B. I., Triviño, A., & Ramírez, J. M. (2016) · BioMed Research International · doi:10.1155/2016/2954721 · Cited by 187 · see citing works

“Listening” and “talking” to neurons: implications of immune activation for pain control and increasing the efficacy of opioids

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Inhibiting neuroinflammation: The role and therapeutic potential of GABA in neuro-immune interactions

Crowley, T., Cryan, J. F., Downer, E. J., & O’Leary, O. F. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.02.001 · Cited by 150 · see citing works

The Involvement of TNF-α in Cognitive Dysfunction Associated with Major Depressive Disorder: An Opportunity for Domain Specific Treatments

Bortolato, B., F. Carvalho, A., K. Soczynska, J., I. Perini, G., & S. McIntyre, R. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150630171433 · Cited by 142 · see citing works

Microglia Activated with the Toll-Like Receptor 9 Ligand CpG Attenuate Oligomeric Amyloid β Neurotoxicity in in Vitro and in Vivo Models of Alzheimer’s Disease

Doi, Y., Mizuno, T., Maki, Y., Jin, S., Mizoguchi, H., Ikeyama, M., Doi, M., Michikawa, M., Takeuchi, H., & Suzumura, A. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090418 · Cited by 135 · see citing works

The TNF-α System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology

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Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of Pathology

Montgomery, S. L., Mastrangelo, M. A., Habib, D., Narrow, W. C., Knowlden, S. A., Wright, T. W., & Bowers, W. J. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.07.001 · Cited by 96 · see citing works

Microglia dysfunction caused by the loss of rhoa disrupts neuronal physiology and leads to neurodegeneration

Socodato, R., Portugal, C. C., Canedo, T., Rodrigues, A., Almeida, T. O., Henriques, J. F., Vaz, S. H., Magalhães, J., Silva, C. M., Baptista, F. I., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107796 · Cited by 94 · see citing works

Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside

Velagapudi, R., El-Bakoush, A., & Olajide, O. A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0975-2 · Cited by 91 · see citing works

Regulation of the neurodegenerative process associated to Parkinson's disease by CD4+ T-cells

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Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions

Sen, Z. D., Danyeli, L. V., Woelfer, M., Lamers, F., Wagner, G., Sobanski, T., & Walter, M. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.12.020 · Cited by 65 · see citing works

LPS and TNF alpha modulate AMPA/NMDA receptor subunit expression and induce PGE2 and glutamate release in preterm fetal ovine mixed glial cultures

Weaver-Mikaere, L., Gunn, A. J., Mitchell, M. D., Bennet, L., & Fraser, M. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-153 · Cited by 29 · see citing works

Recent advances in psychoneuroimmunology: Inflammation in psychiatric disorders

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Intra-amygdala microinjection of TNF-α impairs the auditory fear conditioning of rats via glutamate toxicity

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Roles of Microglia in Synaptogenesis, Synaptic Pruning, and Synaptic Plasticity in Physiological Conditions and Central Nervous System Disorders

Xie, M., Wang, T., Feng, J., Ma, D., Feng, L., & Hao, Y. (2025) · Current Neuropharmacology · doi:10.2174/1570159x23666250225091729 · Cited by 7 · see citing works

A compound CP-31398 suppresses excitotoxicity-induced neurodegeneration

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Neuroprotective Effects of Daphnetin against NMDA Receptor-Mediated Excitotoxicity

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Amyloid β peptide-mediated neurotoxicity is attenuated by the proliferating microglia more potently than by the quiescent phenotype

Tsay, H.-J., Huang, Y., Huang, F.-L., Chen, C.-P., Tsai, Y.-C., Wang, Y.-H., Wu, M.-F., Chiang, F.-Y., & Shiao, Y. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-78 · Cited by 16 · see citing works

Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

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Neuroprotective Effects of Thymosin β4 in Experimental Models of Excitotoxicity

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