The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristem
Open accessAbstract
A central unanswered question in stem cell biology, both in plants and in animals, is how the spatial organization of stem cell niches are maintained as cells move through them. We address this question for the shoot apical meristem (SAM) which harbors pluripotent stem cells responsible for growth of above-ground tissues in flowering plants. We find that localized perception of the plant hormone cytokinin establishes a spatial domain in which cell fate is respecified through induction of the master regulator WUSCHEL as cells are displaced during growth. Cytokinin-induced WUSCHEL expression occurs through both CLAVATA-dependent and CLAVATA-independent pathways. Computational analysis shows that feedback between cytokinin response and genetic regulators predicts their relative patterning, which we confirm experimentally. Our results also may explain how increasing cytokinin concentration leads to the first steps in reestablishing the shoot stem cell niche in vitro.
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Cites
A member of the KNOTTED class of homeodomain proteins encoded by the STM gene of Arabidopsis
Long, J. A., Moan, E. I., Medford, J. I., & Barton, M. K. (1996) · Nature · doi:10.1038/379066a0 · Cited by 1,537
Cited by
Ethylene Role in Plant Growth, Development and Senescence: Interaction with Other Phytohormones
Iqbal, N., Khan, N. A., Ferrante, A., Trivellini, A., Francini, A., & Khan, M. I. R. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00475 · Cited by 1,009
Bartrina, I., Otto, E., Strnad, M., Werner, T., & Schmülling, T. (2011) · The Plant Cell · doi:10.1105/tpc.110.079079 · Cited by 697
WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex
Yadav, R. K., Perales, M., Gruel, J., Girke, T., Jönsson, H., & Reddy, G. V. (2011) · Genes & Development · doi:10.1101/gad.17258511 · Cited by 629
Twenty years on: The inner workings of the shoot apical meristem, a developmental dynamo
Barton, M. K. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.11.029 · Cited by 372
A Two-Step Model for de Novo Activation of WUSCHEL during Plant Shoot Regeneration
Zhang, T.-Q., Lian, H., Zhou, C.-M., Xu, L., Jiao, Y., & Wang, J.-W. (2017) · The Plant Cell · doi:10.1105/tpc.16.00863 · Cited by 357
Metadata
- Authors
- Gordon, S. P., Chickarmane, V. S., Ohno, C., & Meyerowitz, E. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-09-22
- Volume
- 106
- Issue
- 38
- Pages
- 16529-16534
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2156413023
- Cited by
- 530
- References
- 1
- FWCI
- 39.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Gordon, S. P., Chickarmane, V. S., Ohno, C., & Meyerowitz, E. M. (2009). Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristem. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0908122106
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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