A member of the KNOTTED class of homeodomain proteins encoded by the STM gene of Arabidopsis

Long, Jeff A.; Moan, Erich I.; Medford, June I.; Barton, M. Kathryn

doi:10.1038/379066a0

Cited by 1,537Plant Molecular Biology ResearchDevelopmental Biology and Gene RegulationPlant Parasitism and Resistance

A member of the KNOTTED class of homeodomain proteins encoded by the STM gene of Arabidopsis

Long, Jeff A., Moan, Erich I., Medford, June I., Barton, M. Kathryn·1996·Nature

DOI 10.1038/379066a0

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Abstract

The KNOTTED class of plant genes encodes homeodomain proteins. These genes have been found in all plant species where they have been sought and, where examined, show expression patterns that suggest they play an important role in shoot meristem function. Until now, all mutant phenotypes associated with these genes have been due to gain-of-function mutations, making it difficult to deduce their wild-type function. Here we present evidence that the Arabidopsis SHOOT-MERISTEMLESS (STM) gene, required for shoot apical meristem formation during embryogenesis, encodes a class I KNOTTED-like protein. We also describe the expression pattern of this gene in the wild-type plant. To our knowledge, STM is the first gene shown to mark a specific pattern element in the developing plant embryo both phenotypically and molecularly.

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STM function is required for initiation and maintenance of the SAM.
“STM function is required for initiation and maintenance of the SAM (Long et al. 1996).”
From Molecular analysis of the LATERAL SUPPRESSOR gene in Arabidopsis reveals a conserved control mechanism for axillary meristem formation (2003) · cites this paper as Long et al. 1996
STM is expressed in all types of shoot meristems.
“The homeodomain-containing protein SHOOT MERISTEMLESS (STM) was found to be expressed in all types of shoot meristems.”
From Molecular analysis of the LATERAL SUPPRESSOR gene in Arabidopsis reveals a conserved control mechanism for axillary meristem formation (2003) · cites this paper as Long et al. 1996
Meristematic identity of SAM cells is retained by activity of STM.
“Meristematic identity of the SAM cells is retained by activity of the homeobox class I KNOX gene SHOOT MERISTEMLESS (STM; Long et al., 1996; Long and Barton, 2000).”
From Shaping plant architecture (2015) · cites this paper as Long et al., 1996

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Short CommuniCation www.landesbioscience.com Plant Signaling & Behavior e28934-1 Plant Signaling & Behavior 9, e28934; april; © 2014 Landes Bioscience
Communication, S. (2016)
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Authors: Long, J. A., Moan, E. I., Medford, J. I., & Barton, M. K.
Affiliations: University of Wisconsin–Madison (US)
Pennsylvania State University (US)
ORCID: Long, Jeff A.
Medford, June I.
Barton, M. Kathryn
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1996-01
Volume: 379
Issue: 6560
Pages: 66-69
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/379066a0
OpenAlex: W1980630177
Cited by: 1,537
References: 20
Citations by year: 2026: 19 · 2025: 36 · 2024: 46 · 2023: 41 · 2022: 71 · 2021: 37 · 2020: 45 · 2019: 36 · 2018: 35 · 2017: 48 · 2016: 45 · 2015: 43 · 2014: 49 · 2013: 54 · 2012: 63
FWCI: 78.23
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
Keywords: STM, Arabidopsis thaliana, shoot apical meristem, embryonic development, gene expression patterns, gain-of-function mutations, plant development
MeSH terms: Amino Acid Sequence, Molecular Sequence Data, Plant Proteins, Gene Expression, Genes, Plant, Arabidopsis, Sequence Homology, Amino Acid, Homeodomain Proteins, Plant Shoots, RNA, Plant, Arabidopsis Proteins

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A member of the KNOTTED class of homeodomain proteins encoded by the STM gene of Arabidopsis

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