The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease
Open accessAbstract
Constitutive androstane receptor CAR (NR1I3) has been identified as a central mediator of coordinate responses to xenobiotic and endobiotic stress. Here we use leptin-deficient mice (ob/ob) and ob/ob, CAR −/− double mutant mice to identify a metabolic role of CAR in type 2 diabetes. Activation of CAR significantly reduces serum glucose levels and improves glucose tolerance and insulin sensitivity. Gene expression analyses and hyperinsulinemic euglycemic clamp results suggest that CAR activation ameliorates hyperglycemia by suppressing glucose production and stimulating glucose uptake and usage in the liver. In addition, CAR activation dramatically improves fatty liver by both inhibition of hepatic lipogenesis and induction of β-oxidation. We conclude that CAR activation improves type 2 diabetes, and that these actions of CAR suggest therapeutic approaches to the disease.
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Cites
Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function
Wilson, J. E. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00241 · Cited by 1,085
An, J., Muoio, D. M., Shiota, M., Fujimoto, Y., Cline, G. W., Shulman, G. I., Koves, T. R., Stevens, R., Millington, D., & Newgard, C. B. (2004) · Nature Medicine · doi:10.1038/nm995 · Cited by 450
Self-citationSavage, D. B. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27300 · Cited by 447
Abu-Elheiga, L., Oh, W., Kordari, P., & Wakil, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1733877100 · Cited by 389
Self-citationMalonyl-CoA, a Key Signaling Molecule in Mammalian Cells
Saggerson, D. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155434 · Cited by 301
Cited by
Endocrine Disruptors: From Endocrine to Metabolic Disruption
Casals-Casas, C., & Desvergne, B. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142200 · Cited by 902
Hormonal regulation of hepatic glucose production in health and disease
Lin, H. V., & Accili, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.003 · Cited by 429
The xenobiotic receptors PXR and CAR in liver physiology, an update
Cai, X., Young, G. M., & Xie, W. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166101 · Cited by 84
Deciphering the roles of the constitutive androstane receptor in energy metabolism
Yan, J., Chen, B., Lu, J., & Xie, W. (2015) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.102 · Cited by 69
Arrese, M., & Karpen, S. J. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.2 · Cited by 54
Nuclear receptors and liver disease: summary of the 2017 basic research symposium
Tran, M., Liu, Y., Huang, W., & Wang, L. (2018) · Hepatology Communications · doi:10.1002/hep4.1203 · Cited by 20
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Metadata
- Authors
- Dong, B., Saha, P. K., Huang, W., Chen, W., Abu-Elheiga, L. A., Wakil, S. J., Stevens, R. D., Ilkayeva, O., Newgard, C. B., Chan, L., & Moore, D. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-11-03
- Volume
- 106
- Issue
- 44
- Pages
- 18831-18836
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2060802146
- Cited by
- 260
- References
- 5
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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