The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC
Abstract
The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism—as tissue-specific enhancers of MYC .
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“This strong cis interaction - between the amplified, integrated genome of a DNA tumor virus and a canonical proto-oncogene - may underlie the robust growth characteristics of the HeLa cell line, and also provides indirect support for the hypothesis that inherited risk loci for cancer at chromosome 8q24 operate through activation of MYC30.”
From The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line (2013) · cites this paper as [30]
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Cites
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Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
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Metadata
- Authors
- Ahmadiyeh, N., Pomerantz, M. M., Grisanzio, C., Herman, P., Jia, L., Almendro, V., He, H. H., Brown, M., Liu, X. S., Davis, M., Caswell, J. L., Beckwith, C. A., Hills, A., MacConaill, L., Coetzee, G. A., Regan, M. M., & Freedman, M. L.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-05-07
- Volume
- 107
- Issue
- 21
- Pages
- 9742-9746
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 336
- References
- 10
- Language
- en
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