The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.
Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity
Open accessAbstract
Maladaptive auditory cortex reorganization may contribute to the generation and maintenance of tinnitus. Because cortical organization can be modified by behavioral training, we attempted to reduce tinnitus loudness by exposing chronic tinnitus patients to self-chosen, enjoyable music, which was modified (“notched”) to contain no energy in the frequency range surrounding the individual tinnitus frequency. After 12 months of regular listening, the target patient group ( n = 8) showed significantly reduced subjective tinnitus loudness and concomitantly exhibited reduced evoked activity in auditory cortex areas corresponding to the tinnitus frequency compared to patients who had received an analogous placebo notched music treatment ( n = 8). These findings indicate that tinnitus loudness can be significantly diminished by an enjoyable, low-cost, custom-tailored notched music treatment, potentially via reversing maladaptive auditory cortex reorganization.
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“TMNMT has demonstrated significant efficacy in reducing tinnitus distress and is also effective in reducing subjective tinnitus loudness and emotional disturbance.1820”
From SoundMind Trial: a study protocol for a randomised controlled trial for online acceptance and commitment therapy and sound therapy for tinnitus (2024) · cites this paper as [18]
In the citing paper
“TMNMT can inhibit tinnitus by reducing evoked activity in the auditory cortex areas corresponding to the tinnitus frequency.18”
From SoundMind Trial: a study protocol for a randomised controlled trial for online acceptance and commitment therapy and sound therapy for tinnitus (2024) · cites this paper as [18]
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Cites
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“For instance, auditory cortex neurons that are deprived of normal thalamo-cortical input due to hearing loss do not become inactive, but “rewire” with excitatory inputs from neighboring neurons (21, 22).”
BackgroundPhantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation
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Reorganization of auditory cortex in tinnitus
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Cited by
Sorted by citations
Musical Training as a Framework for Brain Plasticity: Behavior, Function, and Structure
Herholz, S. C., & Zatorre, R. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.011 · Cited by 976
Tinnitus: causes and clinical management
Langguth, B., Kreuzer, P. M., Kleinjung, T., & Ridder, D. D. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70160-1 · Cited by 807
Tuning Out the Noise: Limbic-Auditory Interactions in Tinnitus
Rauschecker, J. P., Leaver, A. M., & Mühlau, M. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.032 · Cited by 794
Reversing pathological neural activity using targeted plasticity
Engineer, N. D., Riley, J. R., Seale, J. D., Vrana, W. A., Shetake, J. A., Sudanagunta, S. P., Borland, M. S., & Kilgard, M. P. (2011) · Nature · doi:10.1038/nature09656 · Cited by 662
Maladaptive plasticity in tinnitus — triggers, mechanisms and treatment
Shore, S. E., Roberts, L. E., & Langguth, B. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.12 · Cited by 469
Metadata
- Authors
- Okamoto, H., Stracke, H., Stoll, W., & Pantev, C.
- Affiliations
- University of Münster (DE)
- University Hospital Münster (DE)
- Corresponding author
- Pantev, Christo
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-12-28
- Volume
- 107
- Issue
- 3
- Pages
- 1207-1210
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2824261
- OpenAlex
- W2135640921
- Cited by
- 311
- References
- 50
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 18 · 2023: 51 · 2022: 16 · 2021: 18 · 2020: 19 · 2019: 22 · 2018: 14 · 2017: 11 · 2016: 10 · 2015: 16 · 2014: 17 · 2013: 18 · 2012: 31
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (Pa 392/10-3)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Health Sciences › Health Professions › Speech and Hearing › Hearing Loss and Rehabilitation
- Keywords
- tinnitus, tinnitus loudness, auditory cortex reorganization, music listening, tinnitus frequency, placebo-controlled intervention
- MeSH terms
- Adolescent, Adult, Auditory Cortex, Evoked Potentials, Auditory, Humans, Middle Aged, Music Therapy, Placebos, Tinnitus, Young Adult
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