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STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum
Open accessAbstract
Store-operated calcium entry relies on the formation of a specialized compartment derived from the endoplasmic reticulum (ER) and closely apposed to the plasma membrane. In this study, detailed ultrastructural analysis revealed the existence of three distinct structures derived from conventional ER: precortical ER, cortical ER, and thin cortical ER. Precortical subdomains of the ER enriched in STIM1 can form without contacting the plasma membrane. Upon ER calcium depletion, these subdomains are translocated to the plasma membrane to form cortical ER, which is still connected to the conventional ER. Thin cortical ER, depleted of BiP and deprived of attached ribosomes, may represent a specialized region dedicated to calcium regulation and not engaged in protein translocation and folding. These observations form the basis for future structure-function analysis of cortical ER.
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Citations
Cited by
Store-Operated Calcium Channels
Prakriya, M., & Lewis, R. S. (2015) · Physiological Reviews · doi:10.1152/physrev.00020.2014 · Cited by 1,239
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Hogan, P. G., Lewis, R. S., & Rao, A. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132550 · Cited by 760
Coming together to define membrane contact sites
Scorrano, L., De Matteis, M. A., Emr, S., Giordano, F., Hajnóczky, G., Kornmann, B., Lackner, L. L., Levine, T. P., Pellegrini, L., Reinisch, K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09253-3 · Cited by 730
Contacts between the endoplasmic reticulum and other membranes in neurons
Wu, Y., Whiteus, C., Xu, C. S., Hayworth, K. J., Weinberg, R. J., Hess, H. F., & De Camilli, P. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701078114 · Cited by 477
Organization and Function of Membrane Contact Sites
Helle, S. C. J., Kanfer, G., Kolar, K., Lang, A., Michel, A. H., & Kornmann, B. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.01.028 · Cited by 453
Metadata
- Authors
- Orci, L., Ravazzola, M., Le Coadic, M., Shen, W.-W., Demaurex, N., & Cosson, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-11-17
- Volume
- 106
- Issue
- 46
- Pages
- 19358-19362
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2131685088
- Cited by
- 215
- References
- 0
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Orci, L., Ravazzola, M., Le Coadic, M., Shen, W.-W., Demaurex, N., & Cosson, P. (2009). STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0911280106
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