Organization and Function of Membrane Contact Sites

Helle, Sebastian C.J.; Kanfer, Gil; Kolar, Katja; Lang, Alexander; Michel, Agnès H.; Kornmann, Benoît

doi:10.1016/j.bbamcr.2013.01.028

Cited by 453Cellular transport and secretionIon Channels and ReceptorsLipid Membrane Structure and Behavior

Organization and Function of Membrane Contact Sites

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Helle, Sebastian C.J., Kanfer, Gil, Kolar, Katja, Lang, Alexander, Michel, Agnès H., Kornmann, Benoît·2013·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI 10.1016/j.bbamcr.2013.01.028

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Abstract

Membrane-bound organelles are a wonderful evolutionary acquisition of the eukaryotic cell, allowing the segregation of sometimes incompatible biochemical reactions into specific compartments with tailored microenvironments. On the flip side, these isolating membranes that crowd the interior of the cell, constitute a hindrance to the diffusion of metabolites and information to all corners of the cell. To ensure coordination of cellular activities, cells use a network of contact sites between the membranes of different organelles. These membrane contact sites (MCSs) are domains where two membranes come to close proximity, typically less than 30nm. Such contacts create microdomains that favor exchange between two organelles. MCSs are established and maintained in durable or transient states by tethering structures, which keep the two membranes in proximity, but fusion between the membranes does not take place. Since the endoplasmic reticulum (ER) is the most extensive cellular membrane network, it is thus not surprising to find the ER involved in most MCSs within the cell. The ER contacts diverse compartments such as mitochondria, lysosomes, lipid droplets, the Golgi apparatus, endosomes and the plasma membrane. In this review, we will focus on the common organizing principles underlying the many MCSs found between the ER and virtually all compartments of the cell, and on how the ER establishes a network of MCSs for the trafficking of vital metabolites and information. This article is part of a Special Issue entitled: Functional and structural diversity of endoplasmic reticulum.

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Different organelles are in physical contact with each other and exchange substances and information through their contact sites.
“It has become clear that different organelles are in physical contact with each other and exchange substances and information through their contact sites [19,20].”
From In Candida glabrata, ERMES Component GEM1 Controls Mitochondrial Morphology, mtROS, and Drug Efflux Pump Expression, Resulting in Azole Susceptibility (2023) · cites this paper as [20]

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Authors: Helle, S. C. J., Kanfer, G., Kolar, K., Lang, A., Michel, A. H., & Kornmann, B.
Affiliations: ETH Zurich (CH)
ORCID: Kanfer, Gil
Lang, Alexander
Michel, Agnès H.
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher: Elsevier BV
Published: 2013-11
Volume: 1833
Issue: 11
Pages: 2526-2541
ISSN: 0167-4889 (ISSN-L)
DOI: 10.1016/j.bbamcr.2013.01.028
OpenAlex: W2032362466
Cited by: 453
References: 181
Citations by year: 2026: 22 · 2025: 25 · 2024: 23 · 2023: 21 · 2022: 24 · 2021: 36 · 2020: 37 · 2019: 35 · 2018: 39 · 2017: 42 · 2016: 55 · 2015: 49 · 2014: 30 · 2013: 14
FWCI: 5.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
PubMed (publishedVersion)
Funders: Swiss National Science Foundation (PP00P3_13365)
ETH (ETH 21 11-2)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords: membrane contact sites, endoplasmic reticulum, organelle tethering, ER-mitochondria contact sites, inter-organelle communication, lipid exchange
MeSH terms: Animals, Cell Membrane, Endoplasmic Reticulum, Golgi Apparatus, Humans, Intracellular Membranes, Organelles, Protein Transport

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Organization and Function of Membrane Contact Sites

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