The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Loss of high-frequency glucose-induced Ca 2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5 −/− mice
Open accessAbstract
Glucose homeostasis is critically dependent on insulin release from pancreatic β-cells, which is strictly regulated by glucose-induced oscillations in membrane potential (V m ) and the cytosolic calcium level ([Ca 2+ ] cyt ). We propose that TRPM5, a Ca 2+ -activated monovalent cation channel, is a positive regulator of glucose-induced insulin release. Immunofluorescence revealed expression of TRPM5 in pancreatic islets. A Ca 2+ -activated nonselective cation current with TRPM5-like properties is significantly reduced in Trpm 5 −/− cells. Ca 2+ -imaging and electrophysiological analysis show that glucose-induced oscillations of V m and [Ca 2+ ] cyt have on average a reduced frequency in Trpm5 −/− islets, specifically due to a lack of fast oscillations. As a consequence, glucose-induced insulin release from Trpm5 −/− pancreatic islets is significantly reduced, resulting in an impaired glucose tolerance in Trpm5 −/− mice.
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Gilon, P., Shepherd, R. M., & Henquin, J. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41522-0 · Cited by 329
Self-citationTight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.
Barg, S., Galvanovskis, J., Göpel, S. O., Rorsman, P., & Eliasson, L. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1500 · Cited by 209
Smith, P. A., Ashcroft, F. M., & Rorsman, P. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80667-8 · Cited by 169
Cited by
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793
Transient receptor potential (TRP) channels: a clinical perspective
Kaneko, Y., & Szallasi, A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12414 · Cited by 370
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
Shigeto, M., Ramracheya, R., Tarasov, A. I., Cha, C. Y., Chibalina, M. V., Hastoy, B., Philippaert, K., Reinbothe, T., Rorsman, N., Salehi, A., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81975 · Cited by 189
Self-citationElectrophysiology of pancreatic β-cells in intact mouse islets of Langerhans
Rorsman, P., Eliasson, L., Kanno, T., Zhang, Q., & Gopel, S. (2011) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2011.06.009 · Cited by 103
Ion channels and regulation of insulin secretion in human β-cells: a computational systems analysis
Fridlyand, L. E., Jacobson, D. A., & Philipson, L. H. (2013) · Islets · doi:10.4161/isl.24166 · Cited by 78
Metadata
- Authors
- Colsoul, B., Schraenen, A., Lemaire, K., Quintens, R., Van Lommel, L., Segal, A., Owsianik, G., Talavera, K., Voets, T., Margolskee, R. F., Kokrashvili, Z., Gilon, P., Nilius, B., Schuit, F. C., & Vennekens, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-03
- Volume
- 107
- Issue
- 11
- Pages
- 5208-5213
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2087355933
- Cited by
- 201
- References
- 3
- FWCI
- 16.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Colsoul, B., Schraenen, A., Lemaire, K., Quintens, R., Van Lommel, L., Segal, A., Owsianik, G., Talavera, K., Voets, T., Margolskee, R. F., Kokrashvili, Z., Gilon, P., Nilius, B., Schuit, F. C., & Vennekens, R. (2010). Loss of high-frequency glucose-induced Ca 2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5 −/− mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0913107107
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
