The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Zinc ions promote Alzheimer Aβ aggregation via population shift of polymorphic states
Open accessAbstract
Although a key factor in Alzheimer’s disease etiology is enrichment of Zn 2+ in aggregates, and there are data suggesting that zinc promotes aggregation, how Zn 2+ -A β coordination promotes aggregation is elusive. Here we probe the structures and mechanisms through which Zn 2+ can affect amyloidosis. By covalently linking fragments (that have experiment-based coordinates) we observed that, in oligomeric Zn 2+ -A β 42 , Zn 2+ can simultaneously coordinate intra- and intermolecularly, bridging two peptides. Zinc coordination significantly decreases the solvation energy for large Zn 2+ -A β 42 oligomers and thus enhances their aggregation tendency. Zn 2+ binding does not change the β-sheet association around the C-terminal hydrophobic region; however, it shifts the relative population of the preexisting amyloid polymorphic ensembles. As a result, although a parallel β-sheet arrangement is still preferred, antiparallel and other less structured assemblies are stabilized, also becoming major species. Overall, Zn 2+ coordination promotes A β 42 aggregation leading to less uniform structures. Our replica exchange molecular dynamics simulations further reproduced an experimental observation that the increasing Zn 2+ concentration could slow down the aggregation rate, even though the aggregation rates are still much higher than in Zn 2+ -free solution.
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Self-citationRapid induction of Alzheimer A beta amyloid formation by zinc
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Self-citationBioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide
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Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies
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Biochemistry of Amyloid -Protein and Amyloid Deposits in Alzheimer Disease
Masters, C. L., & Selkoe, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006262 · Cited by 542
Biological metals and metal-targeting compounds in major neurodegenerative diseases
Barnham, K. J., & Bush, A. I. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00138a · Cited by 497
Current understanding of metal ions in the pathogenesis of Alzheimer’s disease
Wang, L., Yin, Y.-L., Liu, X.-Z., Shen, P., Zheng, Y.-G., Lan, X.-R., Lu, C.-B., & Wang, J.-Z. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00189-z · Cited by 454
Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)
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Metadata
- Authors
- Miller, Y., Ma, B., & Nussinov, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-05-06
- Volume
- 107
- Issue
- 21
- Pages
- 9490-9495
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1968041782
- Cited by
- 301
- References
- 9
- FWCI
- 18.07
- Type
- journal article
- Language
- en
- Open access
- green
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