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Cited by 386

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae

Open access
Wang, Guirong, Carey, Allison F., Carlson, John R., Zwiebel, Laurence J.·2010·Proceedings of the National Academy of Sciences

Abstract

A systematic functional analysis across much of the conventional Anopheles gambiae odorant receptor (AgOR) repertoire was carried out in Xenopus oocytes using two-electrode, voltage-clamp electrophysiology. The resulting data indicate that each AgOR manifests a distinct odor-response profile and tuning breadth. The large diversity of tuning responses ranges from AgORs that are responsive to a single or small number of odorants (specialists) to more broadly tuned receptors (generalists). Several AgORs were identified that respond robustly to a range of human volatiles that may play a critical role in anopheline host selection. AgOR responses were analyzed further by constructing a multidimensional odor space representing the relationships between odorants and AgOR responses. Within this space, the distance between odorants is related to both chemical class and concentration and may correlate with olfactory discrimination. This study provides a comprehensive overview of olfactory coding mechanisms of An. gambiae that ultimately may aid in fostering the design and development of olfactory-based strategies for reducing the transmission of malaria and other mosquito-borne diseases.

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Metadata

Authors
Wang, G., Carey, A. F., Carlson, J. R., & Zwiebel, L. J.
Venue
Proceedings of the National Academy of Sciences
Published
2010-02-16
Volume
107
Issue
9
Pages
4418-4423
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2033111008
Cited by
386
References
34
FWCI
7.84
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae. https://app.cochat.ai/papers/10.1073/pnas.0913392107
The paper
Wang, G., Carey, A. F., Carlson, J. R., & Zwiebel, L. J. (2010). Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0913392107

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.