The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae
Open accessAbstract
A systematic functional analysis across much of the conventional Anopheles gambiae odorant receptor (AgOR) repertoire was carried out in Xenopus oocytes using two-electrode, voltage-clamp electrophysiology. The resulting data indicate that each AgOR manifests a distinct odor-response profile and tuning breadth. The large diversity of tuning responses ranges from AgORs that are responsive to a single or small number of odorants (specialists) to more broadly tuned receptors (generalists). Several AgORs were identified that respond robustly to a range of human volatiles that may play a critical role in anopheline host selection. AgOR responses were analyzed further by constructing a multidimensional odor space representing the relationships between odorants and AgOR responses. Within this space, the distance between odorants is related to both chemical class and concentration and may correlate with olfactory discrimination. This study provides a comprehensive overview of olfactory coding mechanisms of An. gambiae that ultimately may aid in fostering the design and development of olfactory-based strategies for reducing the transmission of malaria and other mosquito-borne diseases.
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Cites
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Or83b Encodes a Broadly Expressed Odorant Receptor Essential for Drosophila Olfaction
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Variant Ionotropic Glutamate Receptors as Chemosensory Receptors in Drosophila
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Coding of Odors by a Receptor Repertoire
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Self-citationInsect olfactory receptors are heteromeric ligand-gated ion channels
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Self-citationDrosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels
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Cited by
Roles of indole as an interspecies and interkingdom signaling molecule
Lee, J.-H., Wood, T. K., & Lee, J. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.08.001 · Cited by 516
Distinct Olfactory Signaling Mechanisms in the Malaria Vector Mosquito Anopheles gambiae
Liu, C., Pitts, R. J., Bohbot, J. D., Jones, P. L., Wang, G., & Zwiebel, L. J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000467 · Cited by 154
Self-citationSingle amino acid residue mediates reciprocal specificity in two mosquito odorant receptors
Franco, F. P., Xu, P., Harris, B. J., Yarov-Yarovoy, V., & Leal, W. S. (2022) · eLife · doi:10.7554/elife.82922 · Cited by 14
Metadata
- Authors
- Wang, G., Carey, A. F., Carlson, J. R., & Zwiebel, L. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-02-16
- Volume
- 107
- Issue
- 9
- Pages
- 4418-4423
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2033111008
- Cited by
- 386
- References
- 34
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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