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Distinct Olfactory Signaling Mechanisms in the Malaria Vector Mosquito Anopheles gambiae
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Anopheles gambiae is the principal Afrotropical vector for human malaria, in which olfaction mediates a wide range of both adult and larval behaviors. Indeed, mosquitoes depend on the ability to respond to chemical cues for feeding, host preference, and mate location/selection. Building upon previous work that has characterized a large family of An. gambiae odorant receptors (AgORs), we now use behavioral analyses and gene silencing to examine directly the role of AgORs, as well as a newly identified family of candidate chemosensory genes, the An. gambiae variant ionotropic receptors (AgIRs), in the larval olfactory system. Our results validate previous studies that directly implicate specific AgORs in behavioral responses to DEET as well as other odorants and reveal the existence of at least two distinct olfactory signaling pathways that are active in An. gambiae. One system depends directly on AgORs; the other is AgOR-independent and requires the expression and activity of AgIRs. In addition to clarifying the mechanistic basis for olfaction in this system, these advances may ultimately enhance the development of vector control strategies, targeting olfactory pathways in mosquitoes to reduce the catastrophic effects of malaria and other mosquito-borne diseases.
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There are several electrophysiological and behavioural assays with correspondingly robust analyses currently being used in vector biology research that could be incorporated into such schemes once adopted by WHOPES and the wider scientific community.
“The promising news is that there are several electrophysiological and behavioural assays with correspondingly robust analyses currently being used in vector biology research that could be incorporated into such schemes once adopted by WHOPES and the wider scientific community [16,36-42].”
From Spatial repellents: from discovery and development to evidence-based validation (2012) · cites this paper as [36]
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Metadata
- Authors
- Liu, C., Pitts, R. J., Bohbot, J. D., Jones, P. L., Wang, G., & Zwiebel, L. J.
- Affiliations
- Vanderbilt University (US)
- Agricultural Research Service (US)
- Corresponding author
- Zwiebel, Laurence J.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-08-31
- Volume
- 8
- Issue
- 8
- Pages
- e1000467
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC2930861
- OpenAlex
- W2116602676
- Cited by
- 154
- References
- 29
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 10 · 2021: 13 · 2020: 6 · 2019: 10 · 2018: 16 · 2017: 13 · 2016: 11 · 2015: 10 · 2014: 11 · 2013: 11 · 2012: 13
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Biology (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Foundation for the National Institutes of Health (GCGH #121)
- Vanderbilt University
- Université de Lausanne
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI056402, R01AI056402)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect Pheromone Research and Control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Keywords
- Anopheles gambiae, mosquito olfaction, olfactory receptors, DEET, chemosensory genes, malaria vectors, vector control, gene silencing
- MeSH terms
- Animals, Anopheles, Behavior, Animal, DEET, Insect Repellents, Insect Vectors, Larva, Malaria, Olfactory Pathways, Smell, Signal Transduction, Receptors, Odorant, Gene Silencing, RNA Interference
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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