Cited by 247Ion channel regulation and functionNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

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Metabolic cost as a unifying principle governing neuronal biophysics.

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Hasenstaub, Andrea, Otte, Stephani, Callaway, Edward, Sejnowski, Terrence J.·2010·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0914886107PMC PMC2901447

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Abstract

The brain contains an astonishing diversity of neurons, each expressing only one set of ion channels out of the billions of potential channel combinations. Simple organizing principles are required for us to make sense of this abundance of possibilities and wealth of related data. We suggest that energy minimization subject to functional constraints may be one such unifying principle. We compared the energy needed to produce action potentials singly and in trains for a wide range of channel densities and kinetic parameters and examined which combinations of parameters maximized spiking function while minimizing energetic cost. We confirmed these results for sodium channels using a dynamic current clamp in neocortical fast spiking interneurons. We find further evidence supporting this hypothesis in a wide range of other neurons from several species and conclude that the ion channels in these neurons minimize energy expenditure in their normal range of spiking.

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Authors: Hasenstaub, A., Otte, S., Callaway, E., & Sejnowski, T. J.
Affiliations: Salk Institute for Biological Studies (US)
Crick–Jacobs Center for Theoretical and Computational Biology, Salk Institute for Biological Studies, La Jolla, CA 92037; and
ORCID: Hasenstaub, Andrea
Callaway, Edward
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2010-06-23
Volume: 107
Issue: 27
Pages: 12329-12334
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0914886107
PMC: PMC2901447
OpenAlex: W2164189343
Cited by: 246
References: 72
Citations by year: 2026: 11 · 2025: 13 · 2024: 11 · 2023: 19 · 2022: 21 · 2021: 22 · 2020: 25 · 2019: 14 · 2018: 13 · 2017: 15 · 2016: 16 · 2015: 17 · 2014: 9 · 2013: 11 · 2012: 22
FWCI: 5.21
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Francis Crick Institute
National Institutes of Health
National Institute of Mental Health (MH063912, R01MH063912)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: metabolic cost, energy minimization, ion channel density, sodium channels, action potential trains, fast-spiking interneurons, neocortex, channel kinetics, energy expenditure
MeSH terms: Action Potentials, Sodium-Potassium-Exchanging ATPase, Algorithms, Animals, Brain, Computer Simulation, Energy Metabolism, Ion Channels, Kinetics, Membrane Potentials, Mice, Inbred C57BL, Models, Neurological, Neurons, Potassium, Sodium, Potassium Channels, Sodium Channels, Patch-Clamp Techniques, Mice

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Metabolic cost as a unifying principle governing neuronal biophysics.

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