The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Metabolic cost as a unifying principle governing neuronal biophysics.
Open accessAbstract
The brain contains an astonishing diversity of neurons, each expressing only one set of ion channels out of the billions of potential channel combinations. Simple organizing principles are required for us to make sense of this abundance of possibilities and wealth of related data. We suggest that energy minimization subject to functional constraints may be one such unifying principle. We compared the energy needed to produce action potentials singly and in trains for a wide range of channel densities and kinetic parameters and examined which combinations of parameters maximized spiking function while minimizing energetic cost. We confirmed these results for sodium channels using a dynamic current clamp in neocortical fast spiking interneurons. We find further evidence supporting this hypothesis in a wide range of other neurons from several species and conclude that the ion channels in these neurons minimize energy expenditure in their normal range of spiking.
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“PV cells are particularly susceptible to oxidative stress given their fast cellular metabolism and increased mitochondrial function (Hasenstaub et al., 2010; Kann et al., 2014; Inan et al., 2016).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Hasenstaub et al., 2010
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Metadata
- Authors
- Hasenstaub, A., Otte, S., Callaway, E., & Sejnowski, T. J.
- Affiliations
- Salk Institute for Biological Studies (US)
- Crick–Jacobs Center for Theoretical and Computational Biology, Salk Institute for Biological Studies, La Jolla, CA 92037; and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-06-23
- Volume
- 107
- Issue
- 27
- Pages
- 12329-12334
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2901447
- OpenAlex
- W2164189343
- Cited by
- 246
- References
- 72
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 11 · 2023: 19 · 2022: 21 · 2021: 22 · 2020: 25 · 2019: 14 · 2018: 13 · 2017: 15 · 2016: 16 · 2015: 17 · 2014: 9 · 2013: 11 · 2012: 22
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Francis Crick Institute
- National Institutes of Health
- National Institute of Mental Health (MH063912, R01MH063912)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- metabolic cost, energy minimization, ion channel density, sodium channels, action potential trains, fast-spiking interneurons, neocortex, channel kinetics, energy expenditure
- MeSH terms
- Action Potentials, Sodium-Potassium-Exchanging ATPase, Algorithms, Animals, Brain, Computer Simulation, Energy Metabolism, Ion Channels, Kinetics, Membrane Potentials, Mice, Inbred C57BL, Models, Neurological, Neurons, Potassium, Sodium, Potassium Channels, Sodium Channels, Patch-Clamp Techniques, Mice
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