Variability, compensation and homeostasis in neuron and network function
Abstract
Neurons in most animals live a very long time relative to the half-lives of all of the proteins that govern excitability and synaptic transmission. Consequently, homeostatic mechanisms are necessary to ensure stable neuronal and network function over an animal's lifetime. To understand how these homeostatic mechanisms might function, it is crucial to understand how tightly regulated synaptic and intrinsic properties must be for adequate network performance, and the extent to which compensatory mechanisms allow for multiple solutions to the production of similar behaviour. Here, we use examples from theoretical and experimental studies of invertebrates and vertebrates to explore several issues relevant to understanding the precision of tuning of synaptic and intrinsic currents for the operation of functional neuronal circuits.
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Aerobic glycolysis supports synaptic and neurite formation, as well as turnover, which likely persists throughout the lifespan.
“More specifically, we hypothesize that AG supports synaptic and neurite formation, as well as turnover, which likely persists throughout the lifespan”
From Aerobic glycolysis in the human brain is associated with development and neotenous gene expression (2014) · cites this paper as Marder and Goaillard, 2006
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- Authors
- Marder, E., & Goaillard, J.-M.
- Affiliations
- Brandeis University (US)
- Corresponding author
- Marder, Eve
- Venue
- Nature Reviews Neuroscience
- Published
- 2006-07-01
- Volume
- 7
- Issue
- 7
- Pages
- 563-574
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2059668389
- Cited by
- 1,212
- References
- 5
- Citations by year
- 2026: 52 · 2025: 75 · 2024: 50 · 2023: 49 · 2022: 72 · 2021: 76 · 2020: 67 · 2019: 62 · 2018: 57 · 2017: 66 · 2016: 66 · 2015: 88 · 2014: 51 · 2013: 80 · 2012: 43
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- neuronal homeostasis, synaptic plasticity, compensatory mechanisms, neural variability, synaptic transmission, neuronal excitability, network stability, invertebrate neurons, vertebrate neurons
- MeSH terms
- Action Potentials, Animals, Homeostasis, Humans, Nerve Net, Neurons
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