The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Adeno-associated viruses undergo substantial evolution in primates during natural infections
Open accessAbstract
Adeno-associated viruses (AAVs) are single-stranded DNA viruses that are endemic in human populations without known clinical sequelae and are being evaluated as vectors for human gene therapy. To better understand the biology of this virus, we examined a number of nonhuman primate species for the presence of previously uncharacterized AAVs and characterized their structure and distribution. AAV genomes were widely disseminated throughout multiple tissues of a variety of nonhuman primate species. Surprising diversity of sequence, primarily localized to hypervariable regions of the capsid protein, was detected. This diversity of sequence is caused, in part, by homologous recombination of co-infecting parental viruses that modify the serologic reactivity and tropism of the virus. This is an example of rapid molecular evolution of a DNA virus in a way that was formerly thought to be restricted to RNA viruses.
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Adeno-associated virus vector as a platform for gene therapy delivery
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Self-citationStrategies for delivering therapeutics across the blood–brain barrier
Terstappen, G. C., Meyer, A. H., Bell, R. D., & Zhang, W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00139-y · Cited by 1,138
Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues
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Metadata
- Authors
- Gao, G., Alvira, M. R., Somanathan, S., Lu, Y., Vandenberghe, L. H., Rux, J. J., Calcedo, R., Sanmiguel, J., Abbas, Z., & Wilson, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-04-25
- Volume
- 100
- Issue
- 10
- Pages
- 6081-6086
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2136085939
- Cited by
- 323
- References
- 44
- FWCI
- 10.38
- Type
- journal article
- Language
- en
- Open access
- green
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