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Cited by 36Neuroscience and Neuropharmacology ResearchProtease and Inhibitor MechanismsGenetics and Neurodevelopmental Disorders

Extracellular Metalloproteinases in the Plasticity of Excitatory and Inhibitory Synapses

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Wiera, Grzegorz, Mozrzymas, Jerzy W.·2021·Cells
DOI 10.3390/cells10082055PMC PMC8391609
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Abstract

Long-term synaptic plasticity is shaped by the controlled reorganization of the synaptic proteome. A key component of this process is local proteolysis performed by the family of extracellular matrix metalloproteinases (MMPs). In recent years, considerable progress was achieved in identifying extracellular proteases involved in neuroplasticity phenomena and their protein substrates. Perisynaptic metalloproteinases regulate plastic changes at synapses through the processing of extracellular and membrane proteins. MMP9 was found to play a crucial role in excitatory synapses by controlling the NMDA-dependent LTP component. In addition, MMP3 regulates the L-type calcium channel-dependent form of LTP as well as the plasticity of neuronal excitability. Both MMP9 and MMP3 were implicated in memory and learning. Moreover, altered expression or mutations of different MMPs are associated with learning deficits and psychiatric disorders, including schizophrenia, addiction, or stress response. Contrary to excitatory drive, the investigation into the role of extracellular proteolysis in inhibitory synapses is only just beginning. Herein, we review the principal mechanisms of MMP involvement in the plasticity of excitatory transmission and the recently discovered role of proteolysis in inhibitory synapses. We discuss how different matrix metalloproteinases shape dynamics and turnover of synaptic adhesome and signal transduction pathways in neurons. Finally, we discuss future challenges in exploring synapse- and plasticity-specific functions of different metalloproteinases.

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  • Modification of the CNS ECM by activity-related release of metalloproteinases can cause rapid changes in PNNs in region of synapses, enabling local changes in synaptic properties.

    “An important mechanism of plasticity is modification of the CNS ECM by activity-related release of metalloproteinases, which can cause rapid changes in PNNs in region of synapses, enabling local changes in synaptic properties [38, 58].”

    From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [58]

    The Introduction (section 1; page unavailable) says neuronal activity can prompt MMP secretion and activation, locally loosening ECM and changing synaptic structure and efficacy. Sections 2.2 and 3.1 link MMPs or PNNs to plasticity, but do not establish that activity-related MMP release causes rapid PNN changes specifically near synapses. (LLM, conf=0.82)

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Authors
Wiera, G., & Mozrzymas, J. W.
Affiliations
Wroclaw Medical University (PL)
Corresponding author
  • Wiera, Grzegorz
  • Mozrzymas, Jerzy W.
ORCID
Venue
Cells
Publisher
MDPI AG
Published
2021-08-11
Volume
10
Issue
8
Pages
2055
ISSN
2073-4409 (ISSN-L)
DOI
10.3390/cells10082055
PMC
PMC8391609
OpenAlex
W3188492738
Cited by
36
References
26
Citations by year
2026: 9 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 9
FWCI
0.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Cells (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Narodowe Centrum Nauki (2017/26/D/NZ4/00450, 2018/31/B/NZ4/01998)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
extracellular matrix metalloproteinases, synaptic plasticity, excitatory synapses, inhibitory synapses, long-term potentiation, MMP-9, MMP-3, synaptic proteome, extracellular proteolysis, L-type calcium channels, learning and memory, schizophrenia, mental illness, learning deficits
MeSH terms
Animals, gamma-Aminobutyric Acid, Humans, Learning, Neural Inhibition, Neuronal Plasticity, Synapses, Long-Term Potentiation, Matrix Metalloproteinases, Proteolysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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