The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Modulation of mismatch repair and genomic stability by miR-155
Open accessAbstract
Inactivation of mismatch repair (MMR) is the cause of the common cancer predisposition disorder Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), as well as 10–40% of sporadic colorectal, endometrial, ovarian, gastric, and urothelial cancers. Elevated mutation rates (mutator phenotype), including simple repeat instability [microsatellite instability (MSI)] are a signature of MMR defects. MicroRNAs (miRs) have been implicated in the control of critical cellular pathways involved in development and cancer. Here we show that overexpression of miR-155 significantly down-regulates the core MMR proteins, hMSH2, hMSH6, and hMLH1, inducing a mutator phenotype and MSI. An inverse correlation between the expression of miR-155 and the expression of MLH1 or MSH2 proteins was found in human colorectal cancer. Finally, a number of MSI tumors with unknown cause of MMR inactivation displayed miR-155 overexpression. These data provide support for miR-155 modulation of MMR as a mechanism of cancer pathogenesis.
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MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1997 · Cited by 7,590
Self-citationMicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 7,118
A microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697
Self-citationFriedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
Boland, C. R., Thibodeau, S. N., Hamilton, S. R., Sidransky, D., Eshleman, J. R., Burt, R. W., Meltzer, S. J., Rodrı́guez-Bigas, M. A., Fodde, R., Ranzani, G. N., et al. (1998) · PubMed · Cited by 4,087
Umar, A., Boland, C. R., Terdiman, J. P., Syngal, S., Chapelle, A. D. L., Ruschoff, J., Fishel, R., Lindor, N. M., Burgart, L. J., Hamelin, R., et al. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh034 · Cited by 3,183
Self-citationBeighton, P., & Beighton, G. (1997) · The Person Behind the Syndrome · doi:10.1007/978-1-4471-0925-9_118 · Cited by 3,159
Microsatellite Instability in Cancer of the Proximal Colon
Thibodeau, S. N., Bren, G., & Schaid, D. (1993) · Science · doi:10.1126/science.8484122 · Cited by 3,130
An Extensive Class of Small RNAs in Caenorhabditis elegans
Lee, R. C., & Ambros, V. (2001) · Science · doi:10.1126/science.1065329 · Cited by 2,922
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Valeri, N., Gasparini, P., Braconi, C., Paone, A., Lovat, F., Fabbri, M., Sumani, K. M., Alder, H., Amadori, D., Patel, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015541107 · Cited by 382
Self-citationMicroRNA-155: A Master Regulator of Inflammation
Mahesh, G., & Biswas, R. (2019) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2018.0155 · Cited by 377
Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade
Lee, V., Murphy, A., Le, D. T., & Diaz, L. A. (2016) · The Oncologist · doi:10.1634/theoncologist.2016-0046 · Cited by 283
The role of microRNAs in colorectal cancer
Schetter, A. J., Okayama, H., & Harris, C. C. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e318258b78f · Cited by 252
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Metadata
- Authors
- Valeri, N., Gasparini, P., Fabbri, M., Braconi, C., Veronese, A., Lovat, F., Adair, B., Vannini, I., Fanini, F., Bottoni, A., Costinean, S., Sandhu, S. K., Nuovo, G. J., Alder, H., Gafa, R., Calore, F., Ferracin, M., Lanza, G., Volinia, S., Negrini, M., McIlhatton, M. A., Amadori, D., Fishel, R., & Croce, C. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-03-29
- Volume
- 107
- Issue
- 15
- Pages
- 6982-6987
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2007276591
- Cited by
- 349
- References
- 52
- FWCI
- 21.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Valeri, N., Gasparini, P., Fabbri, M., Braconi, C., Veronese, A., Lovat, F., Adair, B., Vannini, I., Fanini, F., Bottoni, A., Costinean, S., Sandhu, S. K., Nuovo, G. J., Alder, H., Gafa, R., Calore, F., Ferracin, M., Lanza, G., Volinia, S., . . . Croce, C. M. (2010). Modulation of mismatch repair and genomic stability by miR-155. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1002472107
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