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Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H 2 O 2 and superoxide dismutase activity
Abstract
The free radical theory of aging posits oxidative damage to macromolecules as a primary determinant of lifespan. Recent studies challenge this theory by demonstrating that in some cases, longevity is enhanced by inactivation of oxidative stress defenses or is correlated with increased, rather than decreased reactive oxygen species and oxidative damage. Here we show that, in Saccharomyces cerevisiae , caloric restriction or inactivation of catalases extends chronological lifespan by inducing elevated levels of the reactive oxygen species hydrogen peroxide, which activate superoxide dismutases that inhibit the accumulation of superoxide anions. Increased hydrogen peroxide in catalase-deficient cells extends chronological lifespan despite parallel increases in oxidative damage. These findings establish a role for hormesis effects of hydrogen peroxide in promoting longevity that have broad implications for understanding aging and age-related diseases.
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“increased ROS may prolong lifespan in yeast and C. elegans”
From The Hallmarks of Aging (2013) · cites this paper as Mesquita et al., 2010
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Cites
Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes
Gasch, A. P., Spellman, P. T., Kao, C. M., Carmel-Harel, O., Eisen, M. B., Storz, G., Botstein, D., & Brown, P. O. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4241 · Cited by 4,815
Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.011 · Cited by 1,209
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
Passos, J. F., Saretzki, G., Ahmed, S., Nelson, G., Richter, T., Peters, H., Wappler, I., Birket, M. J., Harold, G., Schaeuble, K., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050110 · Cited by 796 · cited 1×
“Superoxide anions inhibit telomere elongation (26) and superoxide dismutases can extend the replicative lifespan of mammalian cells by promoting telomere maintenance (27).”
BackgroundSerra, V., von Zglinicki, T., Lorenz, M., & Saretzki, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207939200 · Cited by 278
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Research works printed but not linked: 26
- 10.1093/geronj/11.3.298 · DOI · Paper page
- 10.4161/cc.7.21.6965 · DOI · Paper page
- 10.1111/j.1474-9726.2006.00237.x · DOI
- 10.1007/s10522-007-9096-4 · DOI
- 10.1089/ars.2009.2728 · DOI
- 10.1089/ars.2006.8.1295 · DOI
- 10.1016/j.mad.2006.11.009 · DOI
- 10.1371/journal.pone.0000748 · DOI
- 10.4161/cc.8.8.8287 · DOI
- 10.4161/cc.8.14.8852 · DOI
- 10.1016/S0891-5849(98)00163-4 · DOI
- 10.1074/jbc.273.35.22480 · DOI
- H Semchyshyn, Hydrogen peroxide-induced response in E. coli and S. cerevisiae: Different stages of the flow of the genetic information. Cent Eur J Biol 4, 142–153 (2009).
- 10.1038/ki.1994.288 · DOI
- 10.1016/S0006-8993(01)02277-6 · DOI
- FC Delori, CK Dorey, In vivo technique for autofluorescent lipopigments. Methods Mol Biol 108, 229–243 (1998).
- 10.1196/annals.1297.015 · DOI
- 10.1080/10715760400022343 · DOI
- 10.1083/jcb.145.4.757 · DOI
- 10.1016/j.cmet.2008.01.001 · DOI
- 10.1111/j.1474-9726.2005.00142.x · DOI
- 10.1016/S0014-5793(03)01462-5 · DOI
- 10.1002/jcb.20208 · DOI
- 10.1111/j.1474-9726.2008.00384.x · DOI
- 10.1164/rccm.200806-851OC · DOI
- 10.1016/j.bbadis.2006.06.011 · DOI
Cited by
Sorted by citations
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
Physiological Roles of Mitochondrial Reactive Oxygen Species
Sena, L. A., & Chandel, N. S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.025 · Cited by 2,632
Human iPSC-based modeling of late-onset disease via progerin-induced aging
Miller, J. D., Ganat, Y. M., Kishinevsky, S., Bowman, R. L., Liu, B., Tu, E. Y., Mandal, P. K., Vera, E., Shim, J.-W., Kriks, S., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.11.006 · Cited by 777
Role of peroxisomes in ros/rns-metabolism: Implications for human disease
Fransen, M., Nordgren, M., Wang, B., & Apanasets, O. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.001 · Cited by 644
Metadata
- Authors
- Mesquita, A., Weinberger, M., Silva, A., Sampaio-Marques, B., Almeida, B., Leão, C., Costa, V., Rodrigues, F., Burhans, W. C., & Ludovico, P.
- Affiliations
- Instituto de Investigação em Ciências da Vida e Saúde (ICVS), Escola de Ciências da Saúde, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal;
- Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263;
- Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4150-180 Porto, Portugal; and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-08-09
- Volume
- 107
- Issue
- 34
- Pages
- 15123-15128
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 240
- References
- 4
- Language
- en
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