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Cited by 279

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid

Open access
Mohamadzadeh, Mansour, Pfeiler, Erika A., Brown, Jeffrey B., Zadeh, Mojgan, Gramarossa, Matthew, Managlia, Elizabeth, Bere, Praveen, Sarraj, Bara, Khan, Mohammad W., Pakanati, Krishna Chaitanya, Ansari, M. Javeed, O'Flaherty, Sarah, Barrett, Terrence, Klaenhammer, Todd R.·2011·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1005066107
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Abstract

Imbalance in the regulatory immune mechanisms that control intestinal cellular and bacterial homeostasis may lead to induction of the detrimental inflammatory signals characterized in humans as inflammatory bowel disease. Induction of proinflammatory cytokines (i.e., IL-12) induced by dendritic cells (DCs) expressing pattern recognition receptors may skew naive T cells to T helper 1 polarization, which is strongly implicated in mucosal autoimmunity. Recent studies show the ability of probiotic microbes to treat and prevent numerous intestinal disorders, including Clostridium difficile -induced colitis. To study the molecular mechanisms involved in the induction and repression of intestinal inflammation, the phosphoglycerol transferase gene that plays a key role in lipoteichoic acid (LTA) biosynthesis in Lactobacillus acidophilus NCFM (NCK56) was deleted. The data show that the L. acidophilus LTA-negative in LTA (NCK2025) not only down-regulated IL-12 and TNFα but also significantly enhanced IL-10 in DCs and controlled the regulation of costimulatory DC functions, resulting in their inability to induce CD4 + T-cell activation. Moreover, treatment of mice with NCK2025 compared with NCK56 significantly mitigated dextran sulfate sodium and CD4 + CD45RB high T cell-induced colitis and effectively ameliorated dextran sulfate sodium-established colitis through a mechanism that involves IL-10 and CD4 + FoxP3 + T regulatory cells to dampen exaggerated mucosal inflammation. Directed alteration of cell surface components of L. acidophilus NCFM establishes a potential strategy for the treatment of inflammatory intestinal disorders.

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Metadata

Authors
Mohamadzadeh, M., Pfeiler, E. A., Brown, J. B., Zadeh, M., Gramarossa, M., Managlia, E., Bere, P., Sarraj, B., Khan, M. W., Pakanati, K. C., Ansari, M. J., O'Flaherty, S., Barrett, T., & Klaenhammer, T. R.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2011-01-31
Volume
108
Issue
supplement_1
Pages
4623-4630
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1005066107
OpenAlex
W1965312946
Cited by
279
References
60
FWCI
42.27
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. https://app.cochat.ai/papers/10.1073/pnas.1005066107
The paper
Mohamadzadeh, M., Pfeiler, E. A., Brown, J. B., Zadeh, M., Gramarossa, M., Managlia, E., Bere, P., Sarraj, B., Khan, M. W., Pakanati, K. C., Ansari, M. J., O'Flaherty, S., Barrett, T., & Klaenhammer, T. R. (2011). Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1005066107

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.