Uterine FK506-binding protein 52 (FKBP52)–peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress

Hirota, Yasushi; Acar, Nuray; Tranguch, Susanne; Burnum, Kristin E.; Xie, Huirong; Kodama, Ako; Osuga, Yutaka; Ustunel, Ismail; Friedman, David B.; Caprioli, Richard M.; Daikoku, Takiko; Dey, Sudhansu K.

doi:10.1073/pnas.1009324107

Uterine FK506-binding protein 52 (FKBP52)–peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress

Immunophilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR) to optimize progesterone (P 4 )-PR signaling. We recently showed that Fkbp52 -deficient ( Fkbp52 −/− ) mice have reduced uterine PR responsiveness and implantation failure which is rescued…