The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells
Open accessAbstract
Radiation therapy can result in bone injury with the development of fractures and often can lead to delayed and nonunion of bone. There is no prevention or treatment for irradiation-induced bone injury. We irradiated the distal half of the mouse left femur to study the mechanism of irradiation-induced bone injury and found that no mesenchymal stem cells (MSCs) were detected in irradiated distal femora or nonirradiated proximal femora. The MSCs in the circulation doubled at 1 week and increased fourfold after 4 wk of irradiation. The number of MSCs in the proximal femur quickly recovered, but no recovery was observed in the distal femur. The levels of free radicals were increased threefold at 1 wk and remained at this high level for 4 wk in distal femora, whereas the levels were increased at 1 wk and returned to the basal level at 4 wk in nonirradiated proximal femur. Free radicals diffuse ipsilaterally to the proximal femur through bone medullary canal. The blood vessels in the distal femora were destroyed in angiographic images, but not in the proximal femora. The osteoclasts and osteoblasts were decreased in the distal femora after irradiation, but no changes were observed in the proximal femora. The total bone volumes were not affected in proximal and distal femora. Our data indicate that irradiation produces free radicals that adversely affect the survival of MSCs in both distal and proximal femora. Irradiation injury to the vasculatures and the microenvironment affect the niches for stem cells during the recovery period.
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Cites
A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991 · cited 1×
“Vasculatures are essential for the maintenance of MSCs as their niche (20, 21).”
BackgroundHematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy.
Mauch, P., Constine, L., Greenberger, J., Knospe, W., Sullivan, J., Liesveld, J. L., & Deeg, H. J. (1995) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(94)00430-s · Cited by 507
Harrison, D. E., & Astle, C. M. (1982) · The Journal of Experimental Medicine · doi:10.1084/jem.156.6.1767 · Cited by 281
Cited by
Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro
Torisawa, Y.-S., Spina, C. S., Mammoto, T., Mammoto, A., Weaver, J. C., Tat, T., Collins, J. J., & Ingber, D. E. (2014) · Nature Methods · doi:10.1038/nmeth.2938 · Cited by 451
Neural Regulation of Hematopoiesis, Inflammation, and Cancer
Hanoun, M., Maryanovich, M., Arnal-Estapé, A., & Frenette, P. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.026 · Cited by 265
SanMiguel, J. M., Eudy, E., Loberg, M. A., Young, K. A., Mistry, J. J., Mujica, K. D., Schwartz, L. S., Stearns, T. M., Challen, G. A., & Trowbridge, J. J. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0086 · Cited by 97
Donneys, A., Weiss, D. M., Deshpande, S. S., Ahsan, S., Tchanque-Fossuo, C. N., Sarhaddi, D., Levi, B., Goldstein, S. A., & Buchman, S. R. (2013) · Bone · doi:10.1016/j.bone.2012.10.014 · Cited by 88
Podophyllum hexandrum and its active constituents: Novel radioprotectants
Anand, U., Biswas, P., Kumar, V., Ray, D., Ray, P., Loake, V. I. P., Kandimalla, R., Chaudhary, A., Singh, B., Routhu, N. K., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112555 · Cited by 41
Metadata
- Authors
- Cao, X., Wu, X., Frassica, D., Yu, B., Pang, L., Xian, L., Wan, M., Lei, W., Armour, M., Tryggestad, E., Wong, J., Wen, C. Y., Lu, W. W., & Frassica, F. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-01-10
- Volume
- 108
- Issue
- 4
- Pages
- 1609-1614
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1966853096
- Cited by
- 257
- References
- 3
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Cao, X., Wu, X., Frassica, D., Yu, B., Pang, L., Xian, L., Wan, M., Lei, W., Armour, M., Tryggestad, E., Wong, J., Wen, C. Y., Lu, W. W., & Frassica, F. J. (2011). Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1015350108
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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