The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo
Open accessAbstract
Hematopoietic stem cells (HSCs) both self-renew and give rise to all blood cells for the lifetime of an individual. Xenogeneic mouse models are broadly used to study human hematopoietic stem and progenitor cell biology in vivo. However, maintenance, differentiation, and function of human hematopoietic cells are suboptimal in these hosts. Thrombopoietin (TPO) has been demonstrated as a crucial cytokine supporting maintenance and self-renewal of HSCs. We generated RAG2 −/− γ c −/− mice in which we replaced the gene encoding mouse TPO by its human homolog. Homozygous humanization of TPO led to increased levels of human engraftment in the bone marrow of the hosts, and multilineage differentiation of hematopoietic cells was improved, with an increased ratio of myelomonocytic verus lymphoid lineages. Moreover, maintenance of human stem and progenitor cells was improved, as demonstrated by serial transplantation. Therefore, RAG2 −/− γ c −/− TPO-humanized mice represent a useful model to study human hematopoiesis in vivo.
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Cites
Of Mice and Not Men: Differences between Mouse and Human Immunology
Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822
Cited by
Hematopoiesis: a human perspective
Doulatov, S., Notta, F., Laurenti, E., & Dick, J. E. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.006 · Cited by 895
Development and function of human innate immune cells in a humanized mouse model
Rongvaux, A., Willinger, T., Martinek, J., Strowig, T., Gearty, S. V., Teichmann, L. L., Saito, Y., Marches, F., Halene, S., Palucka, A. K., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2858 · Cited by 789
Current advances in humanized mouse models
Ito, R., Takahashi, T., Katano, I., & Ito, M. (2012) · Cellular & Molecular Immunology · doi:10.1038/cmi.2012.2 · Cited by 349
McIntosh, B. E., Brown, M. E., Duffin, B. M., Maufort, J. P., Vereide, D. T., Slukvin, I. I., & Thomson, J. A. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.12.005 · Cited by 255
Legrand, N., van der Velden, G. J., Fang, R. H. T., Douaisi, M., Weijer, K., Das, A. T., Blom, B., Uittenbogaart, C. H., Berkhout, B., & Centlivre, M. (2012) · Journal of General Virology · doi:10.1099/vir.0.042796-0 · Cited by 8
Metadata
- Authors
- Rongvaux, A., Willinger, T., Takizawa, H., Rathinam, C., Auerbach, W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Eynon, E. E., Stevens, S., Manz, M. G., & Flavell, R. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-01-24
- Volume
- 108
- Issue
- 6
- Pages
- 2378-2383
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1973127853
- Cited by
- 191
- References
- 1
- FWCI
- 14.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Rongvaux, A., Willinger, T., Takizawa, H., Rathinam, C., Auerbach, W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Eynon, E. E., Stevens, S., Manz, M. G., & Flavell, R. A. (2011). Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1019524108
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