Development and function of human innate immune cells in a humanized mouse model

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works

Macrophage Diversity Enhances Tumor Progression and Metastasis

Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,208 · see citing works

Functions of natural killer cells

Vivier, E., Tomasello, E., Baratin, M., Walzer, T., & Ugolini, S. (2008) · Nature Immunology · doi:10.1038/ni1582 · Cited by 3,943 · see citing works

Of Mice and Not Men: Differences between Mouse and Human Immunology

Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822 · see citing works

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578 · see citing works

The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

Bingle, L., Brown, N. J., & Lewis, C. E. (2002) · The Journal of Pathology · doi:10.1002/path.1027 · Cited by 2,022 · see citing works

Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications

van Rooijen, N., & Sanders, A. (1994) · Journal of Immunological Methods · doi:10.1016/0022-1759(94)90012-4 · Cited by 1,763 · see citing works

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

Auffray, C., Sieweke, M. H., & Geissmann, F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132557 · Cited by 1,647 · see citing works

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors

Cros, J. F., Cagnard, N., Woollard, K. J., Patey, N., Zhang, S., Sénéchal, B., Puel, A., Biswas, S. K., Moshous, D., Pïcard, C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.012 · Cited by 1,251 · see citing works

Of Extracellular Matrix, Scaffolds, and Signaling: Tissue Architecture Regulates Development, Homeostasis, and Cancer

Nelson, C. M., & Bissell, M. J. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104315 · Cited by 1,121 · see citing works

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

Coussens, L. M., Zitvogel, L., & Palucka, A. K. (2013) · Science · doi:10.1126/science.1232227 · Cited by 1,070 · see citing works

Development of a Human Adaptive Immune System in Cord Blood Cell-Transplanted Mice

Traggiai, E., Chicha, L., Mazzucchelli, L., Bronz, L., Piffaretti, J.-C., Lanzavecchia, A., & Manz, M. G. (2004) · Science · doi:10.1126/science.1093933 · Cited by 989 · see citing works

Humanized mice for immune system investigation: progress, promise and challenges

Shultz, L. D., Brehm, M. A., García, J. V., & Greiner, D. L. (2012) · Nature reviews. Immunology · doi:10.1038/nri3311 · Cited by 985 · see citing works

Revisiting the role of the granuloma in tuberculosis

Ramakrishnan, L. (2012) · Nature reviews. Immunology · doi:10.1038/nri3211 · Cited by 887 · see citing works

DIVERSE FUNCTIONS OF IL-2, IL-15, AND IL-7 IN LYMPHOID HOMEOSTASIS

Ma, A. I., Koka, R., & Burkett, P. R. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090727 · Cited by 829 · see citing works

The three human monocyte subsets: implications for health and disease

Wong, K.-L.-O., Yeap, W., Tai, J. J., Ong, S.-M., Dang, T., & Wong, S. (2012) · Immunologic research · doi:10.1007/s12026-012-8297-3 · Cited by 700 · see citing works

Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1

Melkus, M. W., Estes, J. D., Padgett‐Thomas, A., Gatlin, J., Denton, P. W., Othieno, F. A., Wege, A. K., Haase, A. T., & Garcia, J. V. (2006) · Nature Medicine · doi:10.1038/nm1431 · Cited by 653 · see citing works

Deciphering and Reversing Tumor Immune Suppression

Motz, G. T., & Coukos, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.005 · Cited by 600 · see citing works

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

Huntington, N. D., Legrand, N., Alves, N. L., Jaron, B., Weijer, K. C., Plet, A., Corcuff, E., Mortier, E., Jacques, Y., Spits, H., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20082013 · Cited by 578 · see citing works

Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells

Takenaka, K., Prasolava, T. K., Wang, J. C. Y., Mortin-Toth, S. M., Khalouei, S., Gan, O. I., Dick, J. E., & Danska, J. S. (2007) · Nature Immunology · doi:10.1038/ni1527 · Cited by 510 · see citing works

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences

Martínez, F. O., Helming, L., Milde, R., Varin, A., Melgert, B. N., Draijer, C., Thomas, B., Fabbri, M., Crawshaw, A., Ho, L., et al. (2013) · Blood · doi:10.1182/blood-2012-06-436212 · Cited by 495 · see citing works

Enhanced Generation of Specific Tumor-Reactive CTL In Vitro by Selected Melan-A/MART-1 Immunodominant Peptide Analogues

Valmori, D., Fonteneau, J., Marañón, C., Gervois, N., Líénard, D., Rimoldi, D., Jongeneel, C. V., Jotereau, F., Cerottini, J., & Romero, P. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.4.1750 · Cited by 484 · see citing works

Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation

Lan, P., Tonomura, N., Shimizu, A., Wang, S., & Yang, Y. (2006) · Blood · doi:10.1182/blood-2005-11-4388 · Cited by 481 · see citing works

Control of Human Viral Infections by Natural Killer Cells

Jost, S., & Altfeld, M. A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100001 · Cited by 454 · see citing works

Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment

Allavena, P., & Mantovani, A. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04515.x · Cited by 383 · see citing works

Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

Rongvaux, A., Takizawa, H., Strowig, T., Willinger, T., Eynon, E. E., Flavell, R. A., & Manz, M. G. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095921 · Cited by 348 · see citing works

Studying the mononuclear phagocyte system in the molecular age

Chow, A. T., Brown, B. D., & Mérad, M. (2011) · Nature reviews. Immunology · doi:10.1038/nri3087 · Cited by 315 · see citing works

Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation

Brehm, M. A., Cuthbert, A., Yang, C., Miller, D. M., diIorio, P. J., Laning, J. C., Burzenski, L. M., Gott, B., Foreman, O., Kavirayani, A. M., et al. (2010) · Clinical Immunology · doi:10.1016/j.clim.2009.12.008 · Cited by 273 · see citing works

Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice

Chen, Q., Khoury, M., & Chen, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912274106 · Cited by 271 · see citing works

Transgenic expression of human signal regulatory protein alpha in Rag2 −/− γ c −/− mice improves engraftment of human hematopoietic cells in humanized mice

Strowig, T., Rongvaux, A., Rathinam, C., Takizawa, H., Borsotti, C., Philbrick, W. M., Eynon, E. E., Manz, M. G., & Flavell, R. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109769108 · Cited by 228 · see citing works

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

Willinger, T., Rongvaux, A., Takizawa, H., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Auerbach, W., Eynon, E. E., Stevens, S. G., Manz, M. G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019682108 · Cited by 224 · see citing works

Human-Hemato-Lymphoid-System Mice: Opportunities and Challenges

Manz, M. G. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.001 · Cited by 218 · see citing works

Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

Legrand, N., Huntington, N. D., Nagasawa, M., Bakker, A. Q., Schotte, R., Strick‐Marchand, H., de Geus, S. J., Pouw, S. M., Böhne, M., Voordouw, A. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101398108 · Cited by 206 · see citing works

Missing self recognition and self tolerance of natural killer (NK) cells

Raulet, D. H. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.03.003 · Cited by 195 · see citing works

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

Rongvaux, A., Willinger, T., Takizawa, H., Rathinam, C., Auerbach, W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Eynon, E. E., Stevens, S. G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019524108 · Cited by 191 · see citing works

Establishment of a Human Allergy Model Using Human IL-3/GM-CSF–Transgenic NOG Mice

Ito, R., Takahashi, T., Katano, I., Kawai, K., Kamisako, T., Ogura, T., Ida-Tanaka, M., Suemizu, H., Nunomura, S., Ra, C., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203543 · Cited by 165 · see citing works

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

Rathinam, C., Poueymirou, W. T., Rojas, J., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Rongvaux, A., Eynon, E. E., Manz, M. G., & Flavell, R. A. (2011) · Blood · doi:10.1182/blood-2010-12-326926 · Cited by 160 · see citing works

NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration

Nicolini, F. E., Cashman, J., Hogge, D. E., Humphries, R. K., & Eaves, C. J. (2003) · Leukemia · doi:10.1038/sj.leu.2403222 · Cited by 158 · see citing works

Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement

Willinger, T., Rongvaux, A., Strowig, T., Manz, M. G., & Flavell, R. A. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.04.005 · Cited by 128 · see citing works

Development of Mature and Functional Human Myeloid Subsets in Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2rγKO Mice

Tanaka, S., Saito, Y., Kunisawa, J., Kurashima, Y., Wake, T., Suzuki, N., Shultz, L. D., Kiyono, H., & Ishikawa, F. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103660 · Cited by 122 · see citing works

Studies of Lymphocyte Reconstitution in a Humanized Mouse Model Reveal a Requirement of T Cells for Human B Cell Maturation

Lang, J., Kelly, M., Freed, B. M., McCarter, M. D., Kedl, R. M., Torres, R. M., & Pelanda, R. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202810 · Cited by 116 · see citing works

Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence

Strowig, T., Chijioke, O., Carrega, P., Arrey, F., Meixlsperger, S., Rämer, P. C., Ferlazzo, G., & Münz, C. (2010) · Blood · doi:10.1182/blood-2010-02-270678 · Cited by 113 · see citing works

Engraftment of NOD/SCID-β2 microglobulin null mice with multilineage neoplastic cells from patients with myelodysplastic syndrome

Thanopoulou, E., Cashman, J. D., Kakagianne, T., Eaves, A. C., Zoumbos, N. C., & Eaves, C. J. (2004) · Blood · doi:10.1182/blood-2003-09-3192 · Cited by 98 · see citing works

Angiogenesis and the Tumor Vasculature as Antitumor Immune Modulators: The Role of Vascular Endothelial Growth Factor and Endothelin

Kandalaft, L. E., Motz, G. T., Busch, J. I., & Coukos, G. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_95 · Cited by 96 · see citing works

Monocytes control natural killer cell differentiation to effector phenotypes

Soderquest, K., Powell, N., Luci, C., van Rooijen, N., Hidalgo, A., Geissmann, F., Walzer, T., Lord, G. M., & Martin‐Fontecha, A. (2011) · Blood · doi:10.1182/blood-2010-10-312264 · Cited by 93 · see citing works

Engineering humanized mice for improved hematopoietic reconstitution

Drake, A. C. B., Chen, Q., & Chen, J. (2012) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.6 · Cited by 85 · see citing works

Spleens of myelofibrosis patients contain malignant hematopoietic stem cells

Wang, X., Prakash, S., Lü, M., Tripodi, J., Ye, F., Najfeld, V., Li, Y., Schwartz, M., Weinberg, R. S., Roda, P. I., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64397 · Cited by 85 · see citing works

Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγnull mice is enhanced by transgenic expression of membrane-bound human SCF

Brehm, M. A., Racki, W. J., Leif, J., Burzenski, L. M., Hosur, V., Wetmore, A., Gott, B., Herlihy, M., Ignotz, R. A., Dunn, R. M., et al. (2012) · Blood · doi:10.1182/blood-2011-05-353243 · Cited by 82 · see citing works

Monocytes derived from humanized neonatal NOD/SCID/IL2Rγnull mice are phenotypically immature and exhibit functional impairments

Gille, C., Orlikowsky, T. W., Spring, B., Hartwig, U. F., Kübler, A., Wirth, A., Goecke, B., Handgretinger, R., Poets, C. F., & Andre, M. C. (2012) · Human Immunology · doi:10.1016/j.humimm.2012.01.006 · Cited by 51 · see citing works

Induction of Functional Human Macrophages from Bone Marrow Promonocytes by M-CSF in Humanized Mice

Li, Y., Chen, Q., Zheng, D., Yin, L., Chionh, Y. H., Wong, L. H., Tan, S. Q., Tan, T. C., Chan, J. K. Y., Alonso, S., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300742 · Cited by 45 · see citing works

Cancer nanomedicine: progress, challenges and opportunities

Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873 · see citing works

Roles of the immune system in cancer: From tumor initiation to metastatic progression

Gonzalez, H., Hagerling, C., & Werb, Z. (2018) · Genes & Development · doi:10.1101/gad.314617.118 · Cited by 2,111 · see citing works

iPSC-derived human microglia-like cells to study neurological diseases

Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.042 · Cited by 1,154 · see citing works

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Galluzzi, L., Vitale, I., Warren, S., Adjemian, S., Agostinis, P., Buqué, A., Chan, T. A.-T., Coukos, G., Demaria, S., Deutsch, É., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000337 · Cited by 1,151 · see citing works

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

Patel, A. A., Zhang, Y., Fullerton, J. N., Boelen, L., Rongvaux, A., Maini, A. A., Bigley, V., Flavell, R. A., Gilroy, D. W., Asquith, B., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20170355 · Cited by 946 · see citing works

Phagocytosis: An Immunobiologic Process

Gordon, S. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.026 · Cited by 902 · see citing works

Consensus guidelines for the detection of immunogenic cell death

Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., et al. (2014) · OncoImmunology · doi:10.4161/21624011.2014.955691 · Cited by 832 · see citing works

Microenvironmental regulation of therapeutic response in cancer

Klemm, F., & Joyce, J. A. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.11.006 · Cited by 769 · see citing works

Clinical relevance of tumour-associated macrophages

Pittet, M. J., Michielin, O. A., & Migliorini, D. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00620-6 · Cited by 760 · see citing works

Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies

Anderson, K. G., Stromnes, I. M., & Greenberg, P. D. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.008 · Cited by 706 · see citing works

Current hurdles to the translation of nanomedicines from bench to the clinic

Đorđević, S., Gonzalez, M. M., Conejos‐Sánchez, I., Carreira, B., Pozzi, S., Acúrcio, R. C., Satchi‐Fainaro, R., Florindo, H. F., & Vicent, M. J. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01024-2 · Cited by 715 · see citing works

Interrogating open issues in cancer precision medicine with patient-derived xenografts

Byrne, A. T., Alférez, D., Amant, F. C., Annibali, D., Arribas, J., Biankin, A. V., Bruna, A., Budínská, E., Caldas, C., Chang, D. K.-F., et al. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2016.140 · Cited by 663 · see citing works

Tissue-specific macrophages: how they develop and choreograph tissue biology

Mass, E., Nimmerjahn, F., Kierdorf, K., & Schlitzer, A. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00848-y · Cited by 621 · see citing works

Neuroinflammation in Alzheimer disease

Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-024-01104-7 · Cited by 638 · see citing works

Humanized Mouse Models of Clinical Disease

Walsh, N. C., Kenney, L. L., Jangalwe, S., Aryee, K., Greiner, D. L., Brehm, M. A., & Shultz, L. D. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100332 · Cited by 565 · see citing works

Regulation of macrophage immunometabolism in atherosclerosis

Koelwyn, G. J., Corr, E. M., Erbay, E., & Moore, K. J. (2018) · Nature Immunology · doi:10.1038/s41590-018-0113-3 · Cited by 557 · see citing works

Inflammasome activation in infected macrophages drives COVID-19 pathology

Sefik, E., Qu, R., Junqueira, C., Kaffe, E., Mirza, H., Zhao, J., Brewer, J. R., Han, A., Steach, H. R., Israelow, B., et al. (2022) · Nature · doi:10.1038/s41586-022-04802-1 · Cited by 525 · see citing works

Patient-derived xenograft models in cancer therapy: technologies and applications

Liu, Y., Wu, W., Cai, C., Zhang, H., Shen, H., & Han, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01419-2 · Cited by 524 · see citing works

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

Deng, K., Pertea, M., Rongvaux, A., Wang, L., Durand, C. M., Ghiaur, G., Lai, J., McHugh, H., Hao, H., Zhang, H., et al. (2015) · Nature · doi:10.1038/nature14053 · Cited by 499 · see citing works

Humanized mouse models for immuno-oncology research

Chuprin, J., Buettner, H., Seedhom, M. O., Greiner, D. L., Keck, J. G., Ishikawa, F., Shultz, L. D., & Brehm, M. A. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00721-2 · Cited by 423 · see citing works

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo

Hasselmann, J., Coburn, M. A., England, W., Figueroa Velez, D. X., Kiani Shabestari, S., Tu, C. H., McQuade, A., Kolahdouzan, M., Echeverria, K., Claes, C., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.002 · Cited by 380 · see citing works

Generation of hypoimmunogenic human pluripotent stem cells

Han, X., Wang, M., Duan, S., Franco, P. J., Kenty, J. H.-R., Hedrick, P., Xia, Y., Allen, A., Ferreira, L. M. R., Strominger, J. L., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902566116 · Cited by 363 · see citing works

Mouse models in oncoimmunology

Zitvogel, L., Pitt, J. M., Daillère, R., Smyth, M. J., & Kroemer, G. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.91 · Cited by 351 · see citing works

Humanized mice in studying efficacy and mechanisms of PD‐1‐targeted cancer immunotherapy

Wang, M., Yao, L., Cheng, M., Cai, D., Martínek, J., Pan, C.-X., Shi, W., Ma, A., White, R. D., Airhart, S. D., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700740r · Cited by 338 · see citing works

Development of Immunotherapy Combination Strategies in Cancer

Yap, T. A., Parkes, E. E., Peng, W., Moyers, J. T., Curran, M. A., & Tawbi, H. A. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1209 · Cited by 336 · see citing works

Alveolar Macrophages

Joshi, N., Walter, J. M., & Misharin, A. V. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.005 · Cited by 307 · see citing works

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes

Pearson, J. A., Wong, F. S., & Li, W. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.08.019 · Cited by 300 · see citing works

Humanized Mice for the Study of Immuno-Oncology

Rochère, P. D. L., Guil‐Luna, S., Decaudin, D., Azar, G. A., Sidhu, S., & Piaggio, E. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.07.001 · Cited by 292 · see citing works

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy

Claus, C., Ferrara, C., Xu, W., Sam, J., Lang, S., Uhlenbrock, F., Albrecht, R., Herter, S., Schlenker, R., Hüsser, T., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav5989 · Cited by 268 · see citing works

Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation

Reinisch, A., Etchart, N., Thomas, D., Hofmann, N., Frühwirth, M., Sinha, S., Chan, C. K. F., Senarath-Yapa, K., Seo, E. Y., Wearda, T. L., et al. (2014) · Blood · doi:10.1182/blood-2014-04-572255 · Cited by 270 · see citing works

Patient-derived xenograft (PDX) models in basic and translational breast cancer research

Dobrolecki, L. E., Airhart, S., Alférez, D., Aparicio, S. A. J. R., Behbod, F., Bentires‐Alj, M., Brisken, C., Bult, C. J., Cai, S., Clarke, R. B., et al. (2016) · Cancer and Metastasis Reviews · doi:10.1007/s10555-016-9653-x · Cited by 261 · see citing works

Nonirradiated NOD,B6.SCID Il2rγ−/− KitW41/W41 (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells

McIntosh, B. E., Brown, M. E., Duffin, B. M., Maufort, J. P., Vereide, D. T., Slukvin, I. I., & Thomson, J. A. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.12.005 · Cited by 258 · see citing works

The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

Bain, C. C., & MacDonald, A. S. (2022) · Mucosal Immunology · doi:10.1038/s41385-021-00480-w · Cited by 253 · see citing works

Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity

Chen, H.-M., van der Touw, W., Wang, Y. S., Kang, K., Mai, S., Zhang, J., Alsina‐Beauchamp, D., Duty, J. A., Mungamuri, S. K., Zhang, B., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97570 · Cited by 254 · see citing works

Humanized immune system mouse models: progress, challenges and opportunities

Allen, T. M., Brehm, M. A., Bridges, S. H., Ferguson, S. E., Kumar, P., Mirochnitchenko, O., Palucka, K., Pelanda, R., Sanders-Beer, B. E., Shultz, L. D., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0416-z · Cited by 252 · see citing works

Tumor-on-a-chip: from bioinspired design to biomedical application

Liu, X., Fang, J., Huang, S., Wu, X., Xie, X., Wang, J., Liu, F., Zhang, M., Peng, Z., & Hu, N. (2021) · Microsystems & Nanoengineering · doi:10.1038/s41378-021-00277-8 · Cited by 246 · see citing works

Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish

Yan, C., Brunson, D. C., Tang, Q., Do, D., Iftimia, N. A., Moore, J. C., Hayes, M. N., Welker, A. M., Garcia, E. G., Dubash, T. D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.004 · Cited by 242 · see citing works

Humanized Mouse Xenograft Models: Narrowing the Tumor–Microenvironment Gap

Morton, J. J., Bird, G. A., Refaeli, Y., & Jimeno, A. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1260 · Cited by 238 · see citing works

Colonic macrophage polarization in homeostasis, inflammation, and cancer

Isidro, R. A., & Appleyard, C. B. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00123.2016 · Cited by 229 · see citing works

The NAD-booster nicotinamide riboside potently stimulates hematopoiesis through increased mitochondrial clearance

Vannini, N., Campos, V., Girotra, M., Trachsel, V., Rojas-Sutterlin, S., Tratwal, J., Ragusa, S., Stefanidis, E., Ryu, D., Rainer, P. Y., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.02.012 · Cited by 218 · see citing works

A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells

Reinisch, A., Thomas, D., Corces, M. R., Zhang, X., Gratzinger, D. A., Hong, W., Schallmoser, K., Strunk, D., & Majeti, R. (2016) · Nature Medicine · doi:10.1038/nm.4103 · Cited by 222 · see citing works

Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies

Khan, A. O., Rodriguez-Romera, A., Reyat, J. S., Olijnik, A.-A., Colombo, M., Wang, G., Wen, W. X., Sousos, N., Murphy, L. C., Grygielska, B., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0199 · Cited by 219 · see citing works

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease

Lewcock, J. W., Schlepckow, K., Di Paolo, G., Tahirovic, S., Monroe, K. M., & Haass, C. (2020) · Neuron · doi:10.1016/j.neuron.2020.09.029 · Cited by 221 · see citing works

Animal models to study acute and chronic intestinal inflammation in mammals

Jiminez, J. A., Uwiera, T. C., Inglis, G. D., & Uwiera, R. R. E. (2015) · Gut Pathogens · doi:10.1186/s13099-015-0076-y · Cited by 210 · see citing works

Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model ( LSL‐Kras G12D/+ ;LSL‐Trp53 R172H/+ ;Pdx‐1‐Cre ), Its Variants, and Their Application in Immuno‐oncology Drug Discovery

Lee, J. W., Komar, C. A., Bengsch, F., Graham, K. L., & Beatty, G. L. (2016) · Current Protocols in Pharmacology · doi:10.1002/cpph.2 · Cited by 209 · see citing works

Defining the optimal murine models to investigate immune checkpoint blockers and their combination with other immunotherapies

Sanmamed, M. F., Chester, C., Melero, I., & Kohrt, H. E. K. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw041 · Cited by 206 · see citing works

Melanoma models for the next generation of therapies

Patton, E. E., Mueller, K. L., Adams, D. J., Anandasabapathy, N., Aplin, A. E., Bertolotto, C., Bosenberg, M., Ceol, C. J., Burd, C. E., Chi, P., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.01.011 · Cited by 204 · see citing works

Biomaterials for vaccine-based cancer immunotherapy

Zhang, R., Billingsley, M. M., & Mitchell, M. J. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.10.008 · Cited by 201 · see citing works

Subsets of ILC3−ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues

Cella, M., Gamini, R., Sécca, C., Collins, P. L., Zhao, S., Peng, V., Robinette, M. L., Schettini, J. L., Zaitsev, K., Gordon, W., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0425-y · Cited by 196 · see citing works

The development and improvement of immunodeficient mice and humanized immune system mouse models

Chen, J., Liao, S., Xiao, Z., Pan, Q., Wang, X., Shen, K., Wang, S., Yang, L., Guo, F., Liu, H., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1007579 · Cited by 209 · see citing works

AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice

Goettel, J. A., Gandhi, R., Kenison, J. E., Yeste, A., Murugaiyan, G., Sambanthamoorthy, S., Griffith, A. E., Patel, B., Shouval, D. S., Weiner, H. L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.082 · Cited by 190 · see citing works

Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy

Somasundaram, R., Connelly, T., Choi, R., Choi, H., Samarkina, A., Li, L., Gregorio, E., Chen, Y., Thakur, R., Abdel‐Mohsen, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20600-7 · Cited by 187 · see citing works

Distinct developmental pathways from blood monocytes generate human lung macrophage diversity

Evren, E., Ringqvist, E. E., Tripathi, K. P., Sleiers, N., Rives, I. C., Alisjahbana, A., Gao, Y., Sarhan, D., Halle, T., Sorini, C., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.12.003 · Cited by 183 · see citing works

Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier

Cosgun, K. N., Rahmig, S., Mende, N., Reinke, S., Hauber, I., Schäfer, C., Petzold, A., Weisbach, H., Heidkamp, G. F., Purbojo, A., et al. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.06.001 · Cited by 186 · see citing works

Immunobiology of high-grade serous ovarian cancer: lessons for clinical translation

Kandalaft, L. E., Laniti, D. D., & Coukos, G. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00503-z · Cited by 186 · see citing works

Nanoparticle-based medicines in clinical cancer therapy

Wang, S., Cheng, K., Chen, K., Chen, X., Ma, P., Dang, G., Yang, Y., Lei, Q., Huang, H., Yu, Y., et al. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101512 · Cited by 181 · see citing works

Chimeric Antigen Receptor– and TCR-Modified T Cells Enter Main Street and Wall Street

Barrett, D. M., Grupp, S. A., & June, C. H. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500751 · Cited by 180 · see citing works

Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts

Capasso, A., Lang, J., Pitts, T. M., Jordan, K. R., Lieu, C. H., Davis, S. L., Diamond, J. R., Kopetz, S., Barbee, J., Peterson, J. N., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0518-z · Cited by 178 · see citing works

Humanized mouse model supports development, function, and tissue residency of human natural killer cells

Herndler‐Brandstetter, D., Shan, L., Yao, Y., Stecher, C., Plajer, V., Lietzenmayer, M., Strowig, T., de Zoete, M. R., Palm, N. W., Chen, J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705301114 · Cited by 176 · see citing works

Lessons from patient-derived xenografts for better in vitro modeling of human cancer

Choi, S. Y. C., Lin, D., Gout, P. W., Collins, C. C., Xu, Y., & Wang, Y. Z. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.09.009 · Cited by 174 · see citing works

Origin and ontogeny of lung macrophages: from mice to humans

Evren, E., Ringqvist, E. E., & Willinger, T. (2019) · Immunology · doi:10.1111/imm.13154 · Cited by 170 · see citing works

How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

Ioannidis, J. P. A., Kim, B. Y. S., & Trounson, A. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0314-y · Cited by 175 · see citing works

Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice

Das, R., Strowig, T., Verma, R., Koduru, S. V., Hafemann, A., Hopf, S., Kocoglu, M. H., Borsotti, C., Zhang, L., Branagan, A. R., et al. (2016) · Nature Medicine · doi:10.1038/nm.4202 · Cited by 162 · see citing works

Macrophages and HIV-1 – an unhealthy constellation

Sattentau, Q., & Stevenson, M. (2016) · Cell Host and Microbe · doi:10.1016/j.chom.2016.02.013 · Cited by 156 · see citing works

Humanized hemato-lymphoid system mice

Theocharides, A. P. A., Rongvaux, A., Fritsch, K., Flavell, R. A., & Manz, M. G. (2015) · Haematologica · doi:10.3324/haematol.2014.115212 · Cited by 163 · see citing works

An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses

Meraz, I. M., Majidi, M., Meng, F., Shao, R., Ha, M. J., Neri, S., Fang, B., Lin, S. H., Tinkey, P. T., Shpall, E. J., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0874 · Cited by 161 · see citing works

In vitro biomimetic engineering of a human hematopoietic niche with functional properties

Bourgine, P. E., Klein, T., Paczulla, A., Shimizu, T., Kunz, L., Kokkaliaris, K. D., Coutu, D. L., Lengerke, C., Skoda, R. C., Schroeder, T., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805440115 · Cited by 153 · see citing works

A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma

Krepler, C., Sproesser, K., Brafford, P. A., Beqiri, M., Garman, B., Xiao, M., Shannan, B., Watters, A. K., Perego, M., Zhang, G., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.021 · Cited by 151 · see citing works

An Integrative Approach to Precision Cancer Medicine Using Patient-Derived Xenografts

Cho, S., Kang, W., Han, J. Y., Min, S., Kang, J., Lee, A., Kwon, J. Y., Lee, C., & Park, H. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.2350 · Cited by 151 · see citing works

Human iPSC‐derived microglia: A growing toolset to study the brain's innate immune cells

Hasselmann, J., & Blurton‐Jones, M. (2020) · Glia · doi:10.1002/glia.23781 · Cited by 145 · see citing works

Towards precision oncology with patient-derived xenografts

Zanella, E. R., Grassi, E., & Trusolino, L. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00682-6 · Cited by 149 · see citing works

The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases

Wermuth, P. J., & Jiménez, S. A. (2015) · Clinical and Translational Medicine · doi:10.1186/s40169-015-0047-4 · Cited by 138 · see citing works

Human CD56dimCD16dim Cells As an Individualized Natural Killer Cell Subset

Amand, M., Iserentant, G., Poli, A., Sleiman, M., Fiévez, V., Sánchez, I. P., Sauvageot, N., Michel, T., Aouali, N., Janji, B., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00699 · Cited by 141 · see citing works

A Burned-Out CD8+ T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy

Sanmamed, M. F., Nie, X., Desai, S., Villarroel‐Espíndola, F., Badri, T., Zhao, D., Kim, A. W., Ji, L., Zhang, T., Quinlan, E., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0962 · Cited by 140 · see citing works

A unique iridium(III) complex-based chemosensor for multi-signal detection and multi-channel imaging of hypochlorous acid in liver injury

Zhang, F., Liang, X., Zhang, W., Wang, Y., Wang, H., Mohammed, Y., Song, B., Zhang, R., & Yuan, J. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.09.067 · Cited by 137 · see citing works

Innovations, challenges, and minimal information for standardization of humanized mice

Stripecke, R., Münz, C., Schuringa, J. J., Bissig, K., Soper, B. W., Meeham, T., Yao, L., Santo, J. P. D., Brehm, M. A., Rodríguez, E., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201708662 · Cited by 136 · see citing works

Application of Animal Models in Cancer Research: Recent Progress and Future Prospects

Li, Z., Zheng, W., Wang, H., Cheng, Y., Fang, Y., Wu, F., Sun, G., Sun, G., Lv, C., & Hui, B. (2021) · Cancer Management and Research · doi:10.2147/cmar.s302565 · Cited by 140 · see citing works

Myeloid Engraftment in Humanized Mice: Impact of Granulocyte-Colony Stimulating Factor Treatment and Transgenic Mouse Strain

Coughlan, A. M., Harmon, C., Whelan, S., O’Brien, E. C., O’Reilly, V. P., Crotty, P. L., Kelly, P., Ryan, M., Hickey, F. B., O’Farrelly, C., et al. (2016) · Stem Cells and Development · doi:10.1089/scd.2015.0289 · Cited by 134 · see citing works

Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy

Strunz, B., Bister, J., Jönsson, H., Filipovic, I., Guterstam, Y. C., Kvedaraite, E., Sleiers, N., Dumitrescu, B., Brännström, M., Lentini, A., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abb7800 · Cited by 133 · see citing works

A humanized mouse model of chronic COVID-19

Sefik, E., Israelow, B., Mirza, H., Zhao, J., Qu, R., Kaffe, E., Song, E., Halene, S., Meffre, E., Kluger, Y., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-01155-4 · Cited by 129 · see citing works

Advanced nanomedicine and cancer: Challenges and opportunities in clinical translation

González‐Valdivieso, J., Girotti, A., Schneider, J., & Arias, F. J. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120438 · Cited by 131 · see citing works

Xenograft models for normal and malignant stem cells

Goyama, S., Wunderlich, M., & Mulloy, J. C. (2015) · Blood · doi:10.1182/blood-2014-11-570218 · Cited by 127 · see citing works

The microenvironment in human myeloid malignancies: emerging concepts and therapeutic implications

Medyouf, H. (2017) · Blood · doi:10.1182/blood-2016-11-696070 · Cited by 127 · see citing works

Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches

Abarrategi, A., Mian, S. A., Passaro, D., Rouault‐Pierre, K., Grey, W., & Bonnet, D. A. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172139 · Cited by 126 · see citing works

PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages

Yamaguchi, Y., Gibson, J., Ou, K., Lopez, L. S., Ng, R. H., Leggett, N. A., Jönsson, V. D., Zarif, J. C., Lee, P. P., Wang, X., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-004400 · Cited by 128 · see citing works

Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking

Wong, S. W., Lenzini, S. B., Cooper, M. H., Mooney, D. J., & Shin, J. (2020) · Science Advances · doi:10.1126/sciadv.aaw0158 · Cited by 125 · see citing works

XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer

Morton, J. J., Bird, G., Keysar, S. B., Astling, D. P., Lyons, T. R., Anderson, R. T., Glogowska, M., Estes, P., Eagles, J. R., Le, P. N., et al. (2015) · Oncogene · doi:10.1038/onc.2015.94 · Cited by 121 · see citing works

Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth

Hashwah, H., Schmid, C. A., Kasser, S., Bertram, K., Stelling, A., Manz, M. G., & Mueller, A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619555114 · Cited by 121 · see citing works

Cancer CRISPR Screens In Vivo

Chow, R. D.-W., & Chen, S. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.03.002 · Cited by 118 · see citing works

Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice

Rahmig, S., Kronstein‐Wiedemann, R., Fohgrub, J., Kronstein, N., Nevmerzhitskaya, A., Bornhäuser, M., Gassmann, M., Platz, A., Ordemann, R., Tonn, T., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.08.005 · Cited by 118 · see citing works

Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL

McComb, S., Aguadé-Gorgorió, J., Behrmann, L., Marovca, B., Cario, G., Eckert, C., Schrappe, M., Stanulla, M., von Stackelberg, A., Bourquin, J., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad2986 · Cited by 113 · see citing works

Concise Review: Humanized Models of Tumor Immunology in the 21st Century: Convergence of Cancer Research and Tissue Engineering

Holzapfel, B. M., Wagner, F., Thibaudeau, L., Lévesque, J.-P., & Hutmacher, D. W. (2015) · Stem Cells · doi:10.1002/stem.1978 · Cited by 116 · see citing works

Skeletal muscle cells actively shape (auto)immune responses

Afzali, A. M., Müntefering, T., Wiendl, H., Meuth, S. G., & Ruck, T. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.12.005 · Cited by 115 · see citing works

Humanising the mouse genome piece by piece

Zhu, F., Nair, R., Fisher, E., & Cunningham, T. J. (2019) · Nature Communications · doi:10.1038/s41467-019-09716-7 · Cited by 110 · see citing works

Humanized mouse models of immunological diseases and precision medicine

Shultz, L. D., Keck, J., Burzenski, L. M., Jangalwe, S., Vaidya, S., Greiner, D. L., & Brehm, M. A. (2019) · Mammalian Genome · doi:10.1007/s00335-019-09796-2 · Cited by 110 · see citing works

Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

Khawanky, N. E., Hughes, A. H., Yu, W., Myburgh, R., Matschulla, T., Taromi, S., Aumann, K., Clarson, J., Vinnakota, J. M., Shoumariyeh, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26683-0 · Cited by 109 · see citing works

Current State of Animal (Mouse) Modeling in Melanoma Research

Kuzu, O. F., Nguyen, F. D., Noory, M. A., & Sharma, A. K. (2015) · Cancer Growth and Metastasis · doi:10.4137/cgm.s21214 · Cited by 110 · see citing works

Humanized Rodent Models for Cancer Research

Tian, H., Lyu, Y., Yang, Y., & Hu, Z. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01696 · Cited by 108 · see citing works

Natural killer cell–mediated inflammation resolution is disabled in severe asthma

Duvall, M. G., Barnig, C., Cernadas, M., Ricklefs, I., Krishnamoorthy, N., Grossman, N. L., Bhakta, N. R., Fahy, J. V., Bleecker, E. R., Castro, M., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aam5446 · Cited by 107 · see citing works

Techniques to Study Antigen-Specific B Cell Responses

Boonyaratanakornkit, J. B., & Taylor, J. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01694 · Cited by 105 · see citing works

Enhanced development of functional human innate immune cells in a novel mouse FLT3null NSG mouse strain expressing human FLT3L

Vaidya, S., Louis, P. S., Burzenski, L. M., Greiner, D. L., Brehm, M. A., & Shultz, L. D. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.204.supp.223.24 · Cited by 6 · see citing works

Mice with a human innate compartment

Leavy, O. (2014) · Nature reviews. Immunology · doi:10.1038/nri3654

Abstract 1640: Enhanced development of functional human innate immune cells in a novel FLT3nullNSG mouse strain expressing human FLT3L

Yao, L., Vaidya, S., Kaur, P., Keck, J., Shultz, L. D., Greiner, D. L., & Brehm, M. A. (2022) · Cancer Research · doi:10.1158/1538-7445.am2022-1640 · Cited by 5 · see citing works

Abstract 4247: Development of NK humanized mice models for the in vivo evaluation of NK cell engagers

Rettman, P., Bourges, D., Meyer, L.-M., Rangara, R., Ponchet-Lac, A., Moindrot, N., Sidhu, S., & Nicolazzi, C. (2022) · Cancer Research · doi:10.1158/1538-7445.am2022-4247 · Cited by 2 · see citing works

Humanized mouse models to study human diseases

Brehm, M. A., Shultz, L. D., & Greiner, D. L. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328337282f · Cited by 182 · see citing works