The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Sugar-regulated cation channel formed by an insect gustatory receptor
Open accessAbstract
Insects sense the taste of foods and toxic compounds in their environment through the gustatory system. Genetic studies using fruit flies have suggested that putative seven-transmembrane gustatory receptors (Grs) expressed in gustatory sensory neurons are required for responses to specific tastants. We reconstituted sugar responses of Bombyx mori Gr-9 (BmGr-9), a silkworm Gr, in two heterologous expression systems. Xenopus oocytes or HEK293T cells expressing BmGr-9 selectively responded to d -fructose with an influx of extracellular Ca 2+ and a nonselective cation current conductance in a G protein-independent manner. Outside-out patch-clamp recording of BmGr-9–expressing cell membranes provides evidence supporting the hypothesis that BmGr-9 constitutes a ligand-gated ion channel. The fructose-activated current associated with BmGr-9 was suppressed by other hexoses, including glucose and sorbose. The activation and inhibition of insect Gr ion channels may be the molecular basis for the decoding system that discriminates subtle differences in sweet taste. Finally, Drosophila melanogaster Gr43a (DmGr43a), a BmGr-9 ortholog, also responded to d -fructose, suggesting that DmGr43a relatives appear to compose the family of fructose receptors.
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Cites
Insights into social insects from the genome of the honeybee Apis mellifera
The Honeybee Genome Sequencing Consortium (2006) · Nature · doi:10.1038/nature05260 · Cited by 1,865
A Spatial Map of Olfactory Receptor Expression in the Drosophila Antenna
Vosshall, L. B., Amrein, H., Morozov, P. S., Rzhetsky, A., & Axel, R. (1999) · Cell · doi:10.1016/s0092-8674(00)80582-6 · Cited by 1,177
Insect olfactory receptors are heteromeric ligand-gated ion channels
Sato, K., Pellegrino, M., Nakagawa, T., Nakagawa, T., Vosshall, L. B., & Touhara, K. (2008) · Nature · doi:10.1038/nature06850 · Cited by 1,162
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Wicher, D., Schäfer, R., Bauernfeind, R., Stensmyr, M. C., Heller, R., Heinemann, S. H., & Hansson, B. S. (2008) · Nature · doi:10.1038/nature06861 · Cited by 903
Two chemosensory receptors together mediate carbon dioxide detection in Drosophila
Jones, W. D., Cayirlioglu, P., Grunwald Kadow, I., & Vosshall, L. B. (2007) · Nature · doi:10.1038/nature05466 · Cited by 708
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Hill, C. A., Fox, A. N., Pitts, R. J., Kent, L. B., Tan, P. L., Chrystal, M. A., Cravchik, A., Collins, F. H., Robertson, H. M., & Zwiebel, L. J. (2002) · Science · doi:10.1126/science.1076196 · Cited by 665
Candidate Taste Receptors in Drosophila
Clyne, P. J., Warr, C. G., & Carlson, J. R. (2000) · Science · doi:10.1126/science.287.5459.1830 · Cited by 615
Sensing Odorants and Pheromones with Chemosensory Receptors
Touhara, K., & Vosshall, L. B. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163209 · Cited by 563
Self-citationInsect Sex-Pheromone Signals Mediated by Specific Combinations of Olfactory Receptors
Nakagawa, T., Sakurai, T., Nishioka, T., & Touhara, K. (2005) · Science · doi:10.1126/science.1106267 · Cited by 524
Self-citationThe molecular basis of CO 2 reception in Drosophila
Kwon, J. Y., Dahanukar, A., Weiss, L. A., & Carlson, J. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700079104 · Cited by 500
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A gustatory receptor paralogue controls rapid warmth avoidance in Drosophila
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Metadata
- Authors
- Sato, K., Tanaka, K., & Touhara, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-06-27
- Volume
- 108
- Issue
- 28
- Pages
- 11680-11685
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1968173984
- Cited by
- 302
- References
- 27
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- green
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