The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA
Open accessAbstract
Of the three critical enhancer elements that mediate β-cell-specific and glucose-responsive expression of the insulin gene, only the identity of the transcription factor binding to the RIPE3b element (RIPE3b1) has remained elusive. Using a biochemical purification approach, we have identified the RIPE3b1 factor as a m ammalian homologue of avian MafA /L-Maf (mMafA). The avian MafA is a cell-type determination factor that expressed ectopically can trigger lens differentiation program, but no mammalian homologue of avian MafA has previously been identified. Here, we report cloning of the human mafA (hMafA) and demonstrate that it can specifically bind the insulin enhancer element RIPE3b and activate insulin-gene expression. In addition, mMafA has a very restrictive cellular distribution and is selectively expressed in pancreatic β but not in α cells. We suggest that mMafA has an essential role in the function and differentiation of β-cells and thus may be associated with the pathophysiological origins of diabetes.
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Cited by
Kroon, E., Martinson, L. A., Kadoya, K., Bang, A. G., Kelly, O. G., Eliazer, S., Young, H., Richardson, M., Smart, N. G., Cunningham, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1393 · Cited by 1,843
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Developmental biology of the pancreas: A comprehensive review
Gittes, G. K. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.024 · Cited by 451
Molecular regulation of pancreatic β-cell mass development, maintenance, and expansion
Ackermann, A. M., & Gannon, M. (2007) · Journal of Molecular Endocrinology · doi:10.1677/jme-06-0053 · Cited by 262
Direct lineage conversions: unnatural but useful?
Vierbuchen, T., & Wernig, M. (2011) · Nature Biotechnology · doi:10.1038/nbt.1946 · Cited by 259
Metadata
- Authors
- Olbrot, M., Rud, J., Moss, L. G., & Sharma, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-05-14
- Volume
- 99
- Issue
- 10
- Pages
- 6737-6742
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2024665756
- Cited by
- 317
- References
- 34
- FWCI
- 16.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Olbrot, M., Rud, J., Moss, L. G., & Sharma, A. (2002). Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.102168499
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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