The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Selfish genetic elements, genetic conflict, and evolutionary innovation
Open accessAbstract
Genomes are vulnerable to selfish genetic elements (SGEs), which enhance their own transmission relative to the rest of an individual's genome but are neutral or harmful to the individual as a whole. As a result, genetic conflict occurs between SGEs and other genetic elements in the genome. There is growing evidence that SGEs, and the resulting genetic conflict, are an important motor for evolutionary change and innovation. In this review, the kinds of SGEs and their evolutionary consequences are described, including how these elements shape basic biological features, such as genome structure and gene regulation, evolution of new genes, origin of new species, and mechanisms of sex determination and development. The dynamics of SGEs are also considered, including possible “evolutionary functions” of SGEs.
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Cites
(1976) · Cited by 10,423
THE MAJOR TRANSITIONS OF EVOLUTION
Leigh, E. G. (1995) · Evolution · doi:10.1111/j.1558-5646.1995.tb04464.x · Cited by 3,410
Wolbachia: master manipulators of invertebrate biology
Werren, J. H., Baldo, L., & Clark, M. E. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1969 · Cited by 2,819
Self-citationAdaptation and Natural Selection: A Critique of Some Current Evolutionary Thought
Williams, G. C. (2008) · Project Muse (Johns Hopkins University) · doi:10.1515/9781400820108 · Cited by 2,762
Endless Forms: Species and Speciation
Howard, D. J., & Berlocher, S. H. (1998) · Medical Entomology and Zoology · Cited by 2,490
Selfish DNA: the ultimate parasite
Orgel, L. E., & Crick, F. H. C. (1980) · Nature · doi:10.1038/284604a0 · Cited by 2,156
Selfish genes, the phenotype paradigm and genome evolution
Doolittle, W. F., & Sapienza, C. (1980) · Nature · doi:10.1038/284601a0 · Cited by 1,829
The evolutionary dynamics of repetitive DNA in eukaryotes
Charlesworth, B., Sniegowski, P., & Stephan, W. (1994) · Nature · doi:10.1038/371215a0 · Cited by 1,623
Hilgenboecker, K., Hammerstein, P., Schlattmann, P., Telschow, A., & Werren, J. H. (2008) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2008.01110.x · Cited by 1,334
Self-citationTransposable elements and the evolution of regulatory networks
Feschotte, C. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2337 · Cited by 1,328
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Holes in the Hologenome: Why Host-Microbe Symbioses Are Not Holobionts
Douglas, A. E., & Werren, J. H. (2016) · mBio · doi:10.1128/mbio.02099-15 · Cited by 363
Self-citationViruses and mobile elements as drivers of evolutionary transitions
Koonin, E. V. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0442 · Cited by 161
Unravelling the mystery of female meiotic drive: where we are
Clark, F. E., & Akera, T. (2021) · Open Biology · doi:10.1098/rsob.210074 · Cited by 58
Gag proteins encoded by endogenous retroviruses are required for zebrafish development
Chang, N.-C., Wells, J. N., Wang, A. Y., Schofield, P., Huang, Y.-C., Truong, V. H., Simoes-Costa, M., & Feschotte, C. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2411446122 · Cited by 27
Metadata
- Authors
- Werren, J. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-06-20
- Volume
- 108
- Issue
- supplement_2
- Pages
- 10863-10870
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977640433
- Cited by
- 444
- References
- 78
- FWCI
- 29.42
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
