The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer
Open accessAbstract
p63 inhibits metastasis. Here, we show that p63 (both TAp63 and ΔNp63 isoforms) regulates expression of miR-205 in prostate cancer (PCa) cells, and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial-mesenchymal transition (EMT), such as ZEB1 and vimentin. Correspondingly, the inhibitory effect of p63 on EMT markers and cell migration is reverted by anti-miR-205. p53 mutants inhibit expression of both p63 and miR-205, and the cell migration, in a cell line expressing endogenous mutated p53, can be abrogated by pre-miR-205 or silencing of mutated p53. In accordance with this in vitro data, ΔNp63 or miR-205 significantly inhibits the incidence of lung metastasis in vivo in a mouse tail vein model. Similarly, one or both components of the p63/miR-205 axis were absent in metastases or colonized lymph nodes in a set of 218 human prostate cancer samples. This was confirmed in an independent clinical data set of 281 patients. Loss of this axis was associated with higher Gleason scores, an increased likelihood of metastatic and infiltration events, and worse prognosis. These data suggest that p63/miR-205 may be a useful clinical predictor of metastatic behavior in prostate cancer.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“we inhibited p63 and PTEN expression, two genes that are described as tumor-suppressors that play a key role in breast and prostate tissue development (32–35).”
From Direct transfection of clonal organoids in Matrigel microbeads: a promising approach toward organoid-based genetic screens (2018) · cites this paper as [34]
Citations
Cites
Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852
Integrative Genomic Profiling of Human Prostate Cancer
Taylor, B. S., Schultz, N. D., Hieronymus, H., Gopalan, A., Xiao, Y., Carver, B. S., Arora, V. K., Kaushik, P., Cerami, E. G., Reva, B. A., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.05.026 · Cited by 3,713
Yang, A., Kaghad, M., Wang, Y., Gillett, E. S., Fleming, M. D., Dötsch, V., Andrews, N. C., Caput, D., & McKeon, F. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80275-0 · Cited by 2,118
Self-citationGain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
Lang, G. A., Iwakuma, T., Suh, Y.-A., Liu, G., Rao, V. A., Parant, J. M., Valentin-Vega, Y. A., Terzian, T., Caldwell, L. C., Strong, L. C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.006 · Cited by 1,069
Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype
Sarrió, D., Rodríguez-Pinilla, S. M., Hardisson, D., Cano, A., Moreno‐Bueno, G., & Palacios, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2017 · Cited by 1,057
Mutant p53 drives invasion by promoting integrin recycling
Muller, P. A. J., Caswell, P. T., Doyle, B., Iwanicki, M. P., Tan, E. H., Karim, S., Lukashchuk, N., Gillespie, D. A., Ludwig, R. L., Gosselin, P., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.026 · Cited by 796
Self-citationA Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis
Adorno, M., Cordenonsi, M., Montagner, M., Dupont, S., Wong, C., Hann, B. C., Solari, A., Bobisse, S., Rondina, M. B., Guzzardo, V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.01.039 · Cited by 794
MicroRNAs as regulators of epithelial-mesenchymal transition
Gregory, P. A., Bracken, C. P., Bert, A. G., & Goodall, G. J. (2008) · Cell Cycle · doi:10.4161/cc.7.20.6851 · Cited by 521
Flores, E. R., Sengupta, S., Miller, J. B., Newman, J. J., Bronson, R. T., Crowley, D. G., Yang, A., McKeon, F., & Jacks, T. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.019 · Cited by 499
MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets
Baffa, R., Fassan, M., Volinia, S., O’Hara, B. J., Liu, C., Palazzo, J., Gardiman, M. P., Rugge, M., Gomella, L. G., Croce, C. M., et al. (2009) · The Journal of Pathology · doi:10.1002/path.2586 · Cited by 481
Cited by
Sorted by citations
Items 101–200 of 287
Engelmann, D., & Pützer, B. M. (2014) · Science Signaling · doi:10.1126/scisignal.2005699 · Cited by 39
Functions of TAp63 and p53 in restraining the development of metastatic cancer
Tan, E. H., Morton, J. P., Timpson, P., Tucci, P., Melino, G., Flores, E. R., Sansom, O. J., Vousden, K. H., & Muller, P. A. J. (2013) · Oncogene · doi:10.1038/onc.2013.287 · Cited by 39
Self-citationThe diverse oncogenic and tumour suppressor roles of p63 and p73 in cancer: a review by cancer site.
Orzol, P., Holčáková, J., Nekulová, M., Nenutil, R., Vojtěšek, B., & Coates, P. J. (2015) · PubMed · doi:10.14670/hh-30.503 · Cited by 39
Wang, T., Zhao, N., Long, S., Ge, L., Wang, A., Sun, H., Ran, X., Zou, Z., Wang, J., & Su, Y. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.05.004 · Cited by 39
Guo, X., Han, T., Hu, P., Guo, X., Zhu, C., Wang, Y., & Chang, S. (2018) · International Urology and Nephrology · doi:10.1007/s11255-018-2009-4 · Cited by 39
microRNA Expression and Biogenesis in Cellular Response to Ionizing Radiation
Mao, A., Liu, Y., Zhang, H., Di, C., & Sun, C. (2014) · DNA and Cell Biology · doi:10.1089/dna.2014.2401 · Cited by 38
p63 Attenuates Epithelial to Mesenchymal Potential in an Experimental Prostate Cell Model
Olsen, J. R., Oyan, A. M., Rostad, K., Hellem, M. R., Liu, J., Li, L., Micklem, D., Haugen, H., Lorens, J. B., Rotter, V., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062547 · Cited by 38
Noce, A., Canale, M. P., Capria, A., Rovella, V., Tesauro, M., Splendiani, G., Annicchiarico‐Petruzzelli, M., Manzuoli, M., Simonetti, G., & Daniele, N. D. (2015) · Aging · doi:10.18632/aging.100740 · Cited by 38
Deciphering the function of non-coding RNAs in prostate cancer
Ramalho-Carvalho, J., Fromm, B., Henrique, R., & Jerónimo, C. (2016) · Cancer and Metastasis Reviews · doi:10.1007/s10555-016-9628-y · Cited by 39
Mutant p53 stimulates cell invasion through an interaction with Rad21 in human ovarian cancer cells
Ahn, J., Kim, T. J., Lee, J. H., & Choi, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-08880-4 · Cited by 38
Bilodeau, C., Shojaie, S., Goltsis, O., Wang, J., Luo, D., Ackerley, C. A., Rogers, I. M., Cox, B., & Post, M. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00124-4 · Cited by 37
Sailer, V. (2017) · Molecular pathology library · doi:10.1007/978-3-319-64096-9_17 · Cited by 38
The Panel of 12 Cell-Free MicroRNAs as Potential Biomarkers in Prostate Neoplasms
Konoshenko, M. Y., Lekchnov, E. A., Bryzgunova, O. E., Zaporozhchenko, I. A., Yarmoschuk, S. V., Pashkovskaya, O. A., Pak, S. V., & Laktionov, P. P. (2020) · Diagnostics · doi:10.3390/diagnostics10010038 · Cited by 35
Lakshmanachetty, S., Balaiya, V., High, W. A., & Koster, M. I. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-1355 · Cited by 35
Deciphering the significance of p53 mutant proteins
Butera, A., & Amelio, I. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.06.003 · Cited by 36
Lu, J., Lin, Y., Li, F., Ye, H., Zhou, R., Jin, Y., Li, B., Xiong, X., & Cheng, N.-S. (2018) · The FASEB Journal · doi:10.1096/fj.201800113r · Cited by 33
Kim, J., Park, S.-Y., Lee, S. A., Park, M.-G., Yu, S., Lee, M., Park, M., Kim, S.-G., Oh, J., Lee, S., et al. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1872-7 · Cited by 34
MiR-223-5p works as an oncomiR in vulvar carcinoma byTP63suppression
Maia, B. D. M., Rodrigues, I. S., Akagi, E. M., do Amaral, N. S., Ling, H. Y., Monroig-Bosque, P. D. C., Soares, F. A., Călin, G. A., & Rocha, R. M. (2016) · Oncotarget · doi:10.18632/oncotarget.10247 · Cited by 34
Ng, W. L., Chen, G., Wang, M., wang, H., Story, M. D., Shay, J. W., Zhang, X., Wang, J., Amin, A. R. M. R., Hu, B., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.563 · Cited by 32
RetractedXu, C., Li, M., Zhang, L., Bi, Y., Wang, P., Li, J., & Jiang, X. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5118 · Cited by 32
Farina, N. H., Zingiryan, A., Akech, J., Callahan, C. J., Lu, H., Stein, J. L., Languino, L. R., Stein, G. S., & Lian, J. B. (2016) · Oncotarget · doi:10.18632/oncotarget.11992 · Cited by 32
Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks
Li, X. L., Jones, M. F., Subramanian, M., & Lal, A. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.03.054 · Cited by 33
Molecular dynamics of the full-length p53 monomer
Chillemi, G., Davidovich, P. B., D’Abramo, M., Mametnabiev, T. E., Garabadzhiu, A. V., Desideri, A., & Melino, G. (2013) · Cell Cycle · doi:10.4161/cc.26162 · Cited by 31
Self-citationThe tumor suppressive miR-200b subfamily is an ERG target gene in human prostate tumors
Zhang, Z., Lanz, R. B., Xiao, L., Wang, L., Hartig, S. M., Ittmann, M., Feng, Q. F., & He, B. (2016) · Oncotarget · doi:10.18632/oncotarget.9366 · Cited by 32
ΔNp63α suppresses cells invasion by downregulating PKCγ/Rac1 signaling through miR-320a
Aljagthmi, A. A., Hill, N. T., Cooke, M., Kazanietz, M. G., Abba, M. C., Long, W., & Kadakia, M. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1921-6 · Cited by 31
The microRNA feedback regulation of p63 in cancer progression
Lin, C., Li, X., Zhang, Y., Guo, Y., Zhou, J., Gao, K., Dai, J., Hu, G. M., Lv, L., Du, J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3020 · Cited by 31
Zhuang, Z., Xie, N., Hu, J. R., Yu, P., Wang, C., Hu, X., Han, X., Hou, J., Huang, H., & Liu, X. (2017) · Oncotarget · doi:10.18632/oncotarget.15752 · Cited by 31
Ahram, M. A., Mustafa, E. H., Zaza, R., Hammad, S. A., Alhudhud, M., Bawadi, R., & Zihlif, M. A. (2017) · Cell Biology International · doi:10.1002/cbin.10841 · Cited by 31
Spatiotemporal Regulation of ΔNp63 by TGFβ-Regulated miRNAs Is Essential for Cancer Metastasis
Bui, N. H. B., Napoli, M., Davis, A. J., Abbas, H. A., Rajapakshe, K., Coarfa, C., & Flores, E. R. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-2733 · Cited by 31
The role of microRNAs in prostate cancer progression.
Lo, U., Yang, D., & Hsieh, J. (2013) · PubMed Central · doi:10.3978/j.issn.2223-4683.2013.08.01 · Cited by 31
Li, C., Finkelstein, D., & Sherr, C. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302184110 · Cited by 32
Tumor Protein p63/microRNA Network in Epithelial Cancer Cells
Ratovitski, E. A. (2013) · Current Genomics · doi:10.2174/13892029113146660011 · Cited by 30
Nishikawa, R., Goto, Y., Kurozumi, A., Matsushita, R., Enokida, H., Kojima, S., Naya, Y., Nakagawa, M., Ichikawa, T., & Seki, N. (2015) · International Journal of Urology · doi:10.1111/iju.12829 · Cited by 29
p63 Isoforms Regulate Metabolism of Cancer Stem Cells
D’Aguanno, S., Barcaroli, D., Rossi, C., Zucchelli, M., Ciavardelli, D., Cortese, C., Cola, A. D., Volpe, S., D’Agostino, D., Todaro, M., et al. (2014) · Journal of Proteome Research · doi:10.1021/pr4012574 · Cited by 29
The Genomic Landscape of Prostate Cancer
Spans, L., Clinckemalie, L., Helsen, C., Vanderschueren, D., Boonen, S., Lerut, E., Joniau, S., & Claessens, F. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140610822 · Cited by 32
P63 regulates tubular formation via epithelial-to-mesenchymal transition
Zhang, Y., Yan, W., & Chen, X. (2013) · Oncogene · doi:10.1038/onc.2013.101 · Cited by 29
Unraveling cancer lineage drivers in squamous cell carcinomas
Guan, Y., Wang, G., Fails, D. M., Nagarajan, P., & Ge, Y. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107448 · Cited by 30
Moutabian, H., Radi, U. K., Saleman, A. Y., Adil, M., Zabibah, R. S., Chaitanya, M., Saadh, M. J., Jawad, M. J., Hazrati, E., Bagheri, H., et al. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154789 · Cited by 30
The strong propensity of Cadherin‐23 for aggregation inhibits cell migration
Sannigrahi, M. K., Srinivas, C. S., Deokate, N., & Rakshit, S. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12469 · Cited by 27
The Impact of Mutant p53 in the Non-Coding RNA World
Agostino, S. D. (2020) · Biomolecules · doi:10.3390/biom10030472 · Cited by 28
miR-429 inhibits glioma invasion through BMK1 suppression
Chen, W., Zhang, B., Guo, W.-J., Gao, L., Shi, L., Li, H., Lu, S., Liu, Y., & Li, X. (2015) · Journal of Neuro-Oncology · doi:10.1007/s11060-015-1887-x · Cited by 28
p53 overexpression is a prognosticator of poor outcome in esophageal cancer
Melling, N., Norrenbrock, S., Kluth, M., Simon, R., Hube‐Magg, C., Steurer, S. A., Hinsch, A., Burandt, E., Jacobsen, F., Wilczak, W., et al. (2019) · Oncology Letters · doi:10.3892/ol.2019.10020 · Cited by 27
Coix Seed Oil Exerts an Anti–Triple-Negative Breast Cancer Effect by Disrupting miR-205/S1PR1 Axis
Fang, T., Jiang, Y., Chen, L., Huang, L., Tian, X.-H., Zhou, Y., Nagle, D. G., & Zhang, D. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.529962 · Cited by 28
Bevacqua, E., Curcio, M., Saletta, F., Vittorio, O., Cirillo, G., & Tucci, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137013 · Cited by 26
Self-citationZhang, W., Feng, L., Li, Q., Sun, H., Li, F., Jiao, Z., & Lei, J. (2022) · Biology Direct · doi:10.1186/s13062-021-00309-3 · Cited by 26
Role of MicroRNAs in Treatment Response in Prostate Cancer
Razdan, A., SOUZA, P. D., & Roberts, T. L. (2018) · Current Cancer Drug Targets · doi:10.2174/1568009618666180315160125 · Cited by 27
The functions of ocu-miR-205 in regulating hair follicle development in Rex rabbits
Liu, G., Li, S., Liu, H., Zhu, Y., Bai, L., Sun, H., Gao, S., Jiang, W., & Li, F. (2020) · BMC Developmental Biology · doi:10.1186/s12861-020-00213-5 · Cited by 27
ΔNp63 Expression is a Protective Factor of Progression in Clinical High Grade T1 Bladder Cancer
Gaya, J. M., López-Martínez, J. M., Karni-Schmidt, O., Bonal, D. M., Ferran Algaba, B., Palou, J., Villavicencio, H., Benson, M. C., Cordon‐Cardo, C., & Castillo-Martín, M. (2014) · The Journal of Urology · doi:10.1016/j.juro.2014.10.098 · Cited by 25
ΔNp63α and microRNAs: leveraging the epithelial-mesenchymal transition
Stacy, A. J., Craig, M. P., Sakaram, S., & Kadakia, M. (2016) · Oncotarget · doi:10.18632/oncotarget.13797 · Cited by 26
Zhu, L., Wang, G., Fischbach, S., & Xiao, X. (2017) · Oncotarget · doi:10.18632/oncotarget.17012 · Cited by 25
RetractedmiR-26a induced the suppression of tumor growth of cholangiocarcinoma via KRT19 approach
Wang, P., & Lv, L. (2016) · Oncotarget · doi:10.18632/oncotarget.13229 · Cited by 24
ΔNp63α in cancer: importance and therapeutic opportunities
Fisher, M. L., Balinth, S., & Mills, A. A. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.08.003 · Cited by 26
The miR-124-p63 feedback loop modulates colorectal cancer growth
Liu, K., Yao, H., Lei, S., Xiong, L., Qi, H., Qian, K., Liu, J., Wang, P., & Zhao, H. (2017) · Oncotarget · doi:10.18632/oncotarget.16248 · Cited by 24
Hashiguchi, Y., Kawano, S., Goto, Y., Yasuda, K., Kaneko, N., Sakamoto, T., Matsubara, R., Jinno, T., Maruse, Y., Tanaka, H., et al. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26267 · Cited by 24
Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma
Robinson, D. J., Patel, A. A., Purdie, K. J., Wang, J., Rizvi, H., Hufbauer, M., Ostano, P., Akgũl, B., Chiorino, G., Harwood, C. A., et al. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.01.020 · Cited by 24
Barbaro, V., Nasti, A. A., Vecchio, C. D., Ferrari, S., Migliorati, A., Raffa, P., Lariccia, V., Nespeca, P., Biasolo, M. A., Willoughby, C. E., et al. (2016) · Stem Cells · doi:10.1002/stem.2343 · Cited by 24
Niu, M., He, Y., Xu, J., Ding, L., He, T., Yi, Y., Fu, M., Guo, R., Li, F., Chen, H., et al. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001113 · Cited by 24
Retractedp63 transcriptionally regulates the expression of matrix metallopeptidase 13
Celardo, I., Antonov, A., Amelio, I., Annicchiarico‐Petruzzelli, M., & Melino, G. (2014) · Oncotarget · doi:10.18632/oncotarget.1778 · Cited by 25
Self-citationHuman papillomavirus E7 induces p63 expression to modulate DNA damage response
Eldakhakhny, S., Zhou, Q., Crosbie, E. J., & Sayan, B. S. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0149-6 · Cited by 23
Self-citationΔNp63α expression induces loss of cell adhesion in triple-negative breast cancer cells
Nekulová, M., Holčáková, J., Gu, X., Hrabal, V., Galtsidis, S., Orzol, P., Liu, Y., Logotheti, S., Zoumpourlis, V., Nylander, K., et al. (2016) · BMC Cancer · doi:10.1186/s12885-016-2808-x · Cited by 21
Fetiva, M. C., Liss, F., Gertzmann, D., Thomas, J., Gantert, B., Vogl, M., Sira, N., Weinstock, G., Kneitz, S., Ade, C. P., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad107 · Cited by 22
Casaburi, I., Cesario, M. G., Donà, A., Rizza, P., Aquila, S., Avena, P., Lanzino, M., PELLEGRINO, M. A., Vivacqua, A., Tucci, P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7207 · Cited by 24
Self-citationMetabolic pathways regulated by TAp73 in response to oxidative stress
Agostini, M., Annicchiarico‐Petruzzelli, M., Melino, G., & Rufini, A. (2016) · Oncotarget · doi:10.18632/oncotarget.8935 · Cited by 22
Self-citationTRIM29 regulates the p63-mediated pathway in cervical cancer cells
Masuda, Y., Takahashi, H., & Hatakeyama, S. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.05.035 · Cited by 22
Chimenti, M. S., Tucci, P., Candi, E., Perricone, R., Melino, G., & Willis, A. E. (2013) · Cell Cycle · doi:10.4161/cc.26067 · Cited by 21
Self-citationBevacqua, E., Ammirato, S., Cione, E., Curcio, R., Dolce, V., & Tucci, P. (2022) · Cancers · doi:10.3390/cancers14215418 · Cited by 21
Self-citationmicroRNA-205 in prostate cancer: Overview to clinical translation
Chauhan, N., Manojkumar, A., Jaggi, M., Chauhan, S. C., & Yallapu, M. M. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188809 · Cited by 22
DeCastro, A., Cherukuri, P., Balboni, A., & DiRenzo, J. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0194 · Cited by 20
How MicroRNAs Command the Battle against Cancer
Wu, H. H., Leng, S., Sergi, C. M., & Leng, R. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115865 · Cited by 22
Negative feedback between TAp63 and Mir-133b mediates colorectal cancer suppression
Dai, J., Wu, H., Zhang, Y., Gao, K., Hu, G. M., Guo, Y., Lin, C., & Li, X. (2016) · Oncotarget · doi:10.18632/oncotarget.13515 · Cited by 18
The ambiguous role of microRNA-205 and its clinical potential in pancreatic ductal adenocarcinoma
Träger, M. M., Rehkämper, J., Ullerich, H., Steinestel, K., Wardelmann, E., Senninger, N. J., & Dhayat, S. A. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2755-9 · Cited by 19
Long non‑coding RNAs in prostate tumorigenesis and therapy (Review)
Jiang, G., SU, Z., Liang, X., Huang, Y., Lan, Z., & Jiang, X. (2020) · Molecular and Clinical Oncology · doi:10.3892/mco.2020.2146 · Cited by 19
Tanaka, H., & Ogishima, S. (2015) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjv035 · Cited by 19
Nanoparticle‐based targeted cancer strategies for non‐invasive prostate cancer intervention
Farina, N. H., Zingiryan, A., Vrolijk, M. A., Perrapato, S. D., Ades, S., Stein, G. S., Lian, J. B., & Landry, C. C. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26593 · Cited by 18
Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation
Zhou, Q., Eldakhakhny, S., Conforti, F., Crosbie, E. J., Melino, G., & Sayan, B. S. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0521-1 · Cited by 18
Self-citationMicroRNA‑205‑5p regulates extracellular matrix production in hyperplastic scars by targeting Smad2
Qi, J., Liu, Y., Hu, K., Zhang, Y., Wu, Y., & Zhang, X. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7187 · Cited by 18
Calleja, L. R., Lavaud, M., Tesfaye, R. A., Royer, B. B.-L., Baud’huin, M., Georges, S., Lamoureux, F., Verrecchia, F., & Ory, B. (2022) · Cancers · doi:10.3390/cancers14235948 · Cited by 18
Klingauf, M., Beck, M., Berge, U., Turgay, Y., Heinzer, S., Horváth, P., & Kroschewski, R. (2012) · Biology of the Cell · doi:10.1111/boc.201200030 · Cited by 18
Urata, Y. N., Takeshita, F., Tanaka, H., Ochiya, T., & Takimoto, M. (2015) · Scientific Reports · doi:10.1038/srep13676 · Cited by 20
Zhao, W., Wang, H., Han, X., Ma, J., Zhou, Y., Chen, Z., Zhou, H., Xu, H., Sun, Z., Kong, B., et al. (2016) · Tumor Biology · doi:10.1007/s13277-016-4921-5 · Cited by 18
ΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82
di Giacomo, V., Tian, T. V., Mas, A., Pecoraro, M., Batlle‐Morera, L., Noya, L., Martín‐Caballero, J., Ruberte, J., & Keyes, W. M. (2017) · Oncogene · doi:10.1038/onc.2017.42 · Cited by 18
The p53 Family in Brain Disease
Agostini, M., Melino, G., & Bernassola, F. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7302 · Cited by 19
Self-citationMicroRNAs that affect prostate cancer: emphasis on prostate cancer in African Americans
Jones, J., Grizzle, W. E., Wang, H., & Yates, C. C. (2013) · Biotechnic & Histochemistry · doi:10.3109/10520295.2013.807069 · Cited by 17
Nordby, Y., Richardsen, E. H., Ness, N., Dønnem, T., Patel, H., Busund, L., Bremnes, R. M., & Andersen, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-16556-2 · Cited by 17
Maurelli, R., Tinaburri, L., Gangi, F. M., Bondanza, S., Severi, A. L., Scarponi, C., Albanesi, C., Mesiti, G., Guerra, L., Capogrossi, M. C., et al. (2016) · Journal of Cell Science · doi:10.1242/jcs.176842 · Cited by 17
Shan, Z., Qinglan, H., Zhang, N., Guo, L., ZHANG, X., Yaohui, M., & Zhou, Y. (2014) · Oncology Reports · doi:10.3892/or.2014.3407 · Cited by 16
Unnatural killer cells to prevent bloodborne metastasis: inspiration from biology and engineering
Mitchell, M. J., & King, M. R. (2014) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2014.916619 · Cited by 16
p53 Mutation in the Genesis of Metastasis
Yeudall, W. A. (2014) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-9211-0_6 · Cited by 15
The “Sharp”blade against HIF-mediated metastasis
Amelio, I., & Melino, G. (2012) · Cell Cycle · doi:10.4161/cc.22820 · Cited by 15
Self-citationTAp63 regulates oncogenic miR-155 to mediate migration and tumour growth
Mattiske, S., Ho, K., Noll, J. E., Neilsen, P. M., Callen, D. F., & Suetani, R. J. (2013) · Oncotarget · doi:10.18632/oncotarget.1228 · Cited by 15
Alhaddad, L., Pustovalova, M. V., Blokhina, T., Chuprov‐Netochin, R. N., Osipov, A. N., & Leonov, S. V. (2021) · Cancers · doi:10.3390/cancers13112669 · Cited by 15
miRNAs as drivers of TMPRSS2-ERG negative prostate tumors in African American men
Campbell, M. J. (2016) · Frontiers in bioscience · doi:10.2741/4482 · Cited by 14
MicroRNA-133b is regulated by TAp63 while no gene mutation is present in colorectal cancer
Chen, Y., Zhang, Y., He, J., Fu, Y., Lin, C., & Li, X. (2017) · Oncology Reports · doi:10.3892/or.2017.5371 · Cited by 14
Role of exosomal small RNA in prostate cancer metastasis
Zhan, F., Shen, J., Wang, R., Wang, L., Dai, Y., Zhang, Y., & Huang, X. (2018) · Cancer Management and Research · doi:10.2147/cmar.s170610 · Cited by 14
Galoczová, M., Nenutil, R., Pokorná, Z., Vojtěšek, B., & Coates, P. J. (2020) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-020-02944-z · Cited by 13
Cava, C., Bertoli, G. R., Colaprico, A., Bontempi, G., Mauri, G., & Castiglioni, I. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030910 · Cited by 13
Nectin‐4 and p63 immunohistochemical expression in canine prostate tumourigenesis
Della Salda, L., Massimini, M., Romanucci, M., Palmieri, C., Perillo, A., Grieco, V., Malatesta, D., Spinillo, M. A., Passantino, G., Dondi, F., et al. (2019) · Veterinary and Comparative Oncology · doi:10.1111/vco.12469 · Cited by 13
Alshammari, E. S., Aljagthmi, A. A., Stacy, A. J., Bottomley, M., Shamma, H. N., Kadakia, M., & Long, W. (2021) · BMC Cancer · doi:10.1186/s12885-021-07866-w · Cited by 13
Convergence of dispersed regulatory mutations predicts driver genes in prostate cancerPreprint
Sallari, R. C., Sinnott-Armstrong, N., French, J. D., Kron, K. J., Ho, J., Moore, J. H., Stambolic, V., Edwards, S. L., Lupien, M., & Kellis, M. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/097451 · Cited by 12
Murine double minute 2, a potential p53-independent regulator of liver cancer metastasis
Ranjan, A., Bera, K., & Iwakuma, T. (2016) · Hepatoma Research · doi:10.20517/2394-5079.2015.67 · Cited by 12
Metadata
- Authors
- Tucci, P., Agostini, M., Grespi, F., Markert, E. K., Terrinoni, A., Vousden, K. H., Muller, P. A. J., Dötsch, V., Kehrloesser, S., Sayan, B. S., Giaccone, G., Lowe, S. W., Takahashi, N., Vandenabeele, P., Knight, R. A., Levine, A. J., & Melino, G.
- Affiliations
- University of Leicester (GB)
- Institute for Advanced Study (US)
- University of Rome Tor Vergata (IT)
- Cancer Research UK Scotland Institute (GB)
- Goethe University Frankfurt (DE)
- University of Southampton (GB)
- National Institutes of Health (US)
- Memorial Sloan Kettering Cancer Center (US)
- Vlaams Instituut voor Biotechnologie (BE)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-09-04
- Volume
- 109
- Issue
- 38
- Pages
- 15312-15317
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3458363
- OpenAlex
- W2113645544
- Cited by
- 286
- References
- 28
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 11 · 2023: 14 · 2022: 12 · 2021: 20 · 2020: 17 · 2019: 15 · 2018: 18 · 2017: 19 · 2016: 37 · 2015: 30 · 2014: 41 · 2013: 36 · 2012: 6
- FWCI
- 12.00
- Type
- journal article
- Language
- en
- Update notices
- correction (2014-01-17)
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Salford Institutional Repository (University of Salford) (submittedVersion, cc-by)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Durham Research Online (Durham University) (submittedVersion, cc-by)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Ministero della Salute
- Vlaams Instituut voor Biotechnologie
- Associazione Italiana per la Ricerca sul Cancro (2008-2010_33-08)
- Vlaamse regering
- Alleanza Contro il Cancro
- Medical Research Council (ACC12)
- National Cancer Institute (P01CA087497, P01CA87497.)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- p63, miR-205, prostate cancer, metastasis, cell migration, epithelial-mesenchymal transition, ZEB1, vimentin, TP53 mutation, ΔNp63, TAp63, lung metastasis, lymph node metastasis, Gleason score, prognostic factors
- MeSH terms
- Animals, Cell Movement, Humans, Male, Mice, Inbred BALB C, Mutation, Neoplasm Metastasis, Neoplasm Transplantation, Phosphoproteins, Prostatic Neoplasms, Transcription Factors, Biomarkers, Tumor, Trans-Activators, Gene Expression Regulation, Neoplastic, Protein Isoforms, Gene Expression Profiling, Tumor Suppressor Proteins, MicroRNAs, Cell Line, Tumor, Cell Proliferation, Mice, Epithelial-Mesenchymal Transition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review