Vousden, Karen H.

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

Regulation of p53 stability by Mdm2

Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 3,312

Blinded by the Light: The Growing Complexity of p53

Vousden, K. H., & Prives, C. (2009) · Cell

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 3,163

TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell

Cancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism

Cited by 2,019

p53 mutations in cancer

Muller, P. A. J., & Vousden, K. H. (2013) · Nature Cell Biology

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 1,647

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

Muller, P. A. J., & Vousden, K. H. (2014) · Cancer Cell

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 1,545

P53 in survival, death and metabolic health: a lifeguard with a licence to kill.

Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology

Cancer-related Molecular PathwaysMetabolism, Diabetes, and Cancer

Cited by 1,080

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

Fang, S., Jensen, J. P., Ludwig, R. L., Vousden, K. H., & Weissman, A. M. (2000) · Journal of Biological Chemistry

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 1,044

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

Maddocks, O. D. K., Berkers, C. R., Mason, S. M., Zheng, L., Blyth, K., Gottlieb, E., & Vousden, K. H. (2013) · Nature

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 1,007

Serine and one-carbon metabolism in cancer

Yang, M., & Vousden, K. H. (2016) · Nature Reviews Cancer

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 992

p53 and metabolism

Vousden, K. H., & Ryan, K. M. (2009) · Nature Reviews Cancer

Cancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism

Cited by 959

p14ARF links the tumour suppressors RB and p53

Bates, S., Phillips, A. C., Clark, P. A., Stott, F., Peters, G., Ludwig, R. L., & Vousden, K. H. (1998) · Nature

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 918

Mutant p53 drives invasion by promoting integrin recycling

Muller, P. A. J., Caswell, P. T., Doyle, B., Iwanicki, M. P., Tan, E. H., Karim, S., Lukashchuk, N., Gillespie, D. A., Ludwig, R. L., Gosselin, P., et al. (2009) · Cell

Cancer-related Molecular PathwaysCell Adhesion Molecules Research

Cited by 796

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Chaneton, B., Hillmann, P., Zheng, L., Martin, A. C. L., Maddocks, O. D. K., Chokkathukalam, A., Coyle, J. E., Jankevics, A., Holding, F. P., Vousden, K. H., et al. (2012) · Nature

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 661

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

Maddocks, O. D. K., Athineos, D., Cheung, E. C., Lee, P., Zhang, T., van den Broek, N. J. F., Mackay, G. M., Labuschagne, C. F., Gay, D., Kruiswijk, F., et al. (2017) · Nature

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 603

Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells

Labuschagne, C. F., van den Broek, N. J. F., Mackay, G. M., Vousden, K. H., & Maddocks, O. D. K. (2014) · Cell Reports

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 576

Coping with stress: multiple ways to activate p53

Horn, H. F., & Vousden, K. H. (2007) · Oncogene

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 522

p53 and its mutants in tumor cell migration and invasion

Muller, P. A. J., Vousden, K. H., & Norman, J. C. (2011) · Journal of Cell Biology

Cancer-related Molecular PathwaysMechanisms of cancer metastasis

Cited by 463

Regulation of p53 function and stability by phosphorylation.

Ashcroft, M., Kubbutat, M. H. G., & Vousden, K. H. (1999) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 452

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

Melino, G., Bernassola, F., Ranalli, M., Yee, K., Zong, W. X., Corazzari, M., Knight, R. A., Green, D. R., Thompson, C., & Vousden, K. H. (2004) · Journal of Biological Chemistry

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 368

p53, cancer and the immune response

Blagih, J., Buck, M. D., & Vousden, K. H. (2020) · Journal of Cell Science

Cancer-related Molecular PathwaysCancer Immunotherapy and Biomarkers

Cited by 333

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

Tucci, P., Agostini, M., Grespi, F., Markert, E. K., Terrinoni, A., Vousden, K. H., Muller, P. A. J., Dötsch, V., Kehrloesser, S., Sayan, B. S., et al. (2012) · Proceedings of the National Academy of Sciences

MicroRNA in disease regulationProstate Cancer Treatment and Research

Cited by 286

p53 is frequently mutated in Burkitt's lymphoma cell lines

Farrell, P. J., Allan, G. J., Shanahan, F., Vousden, K. H., & Crook, T. (1991) · The EMBO Journal

Cancer-related Molecular PathwaysLymphoma Diagnosis and Treatment

Cited by 254

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3

Tajan, M., Hock, A. K., Blagih, J., Robertson, N. A., Labuschagne, C. F., Kruiswijk, F., Humpton, T. J., Adams, P. D., & Vousden, K. H. (2018) · Cell Metabolism

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 230