Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

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Integrative Genomic Profiling of Human Prostate Cancer

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p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome

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Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype

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Mutant p53 drives invasion by promoting integrin recycling

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A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

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MicroRNAs as regulators of epithelial-mesenchymal transition

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Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family

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MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets

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Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

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Senescence and aging: the critical roles of p53

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p53 signaling in cancer progression and therapy

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MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells

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miR-34: from bench to bedside

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TRAIL-coated leukocytes that kill cancer cells in the circulation

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Circulating tumor cells: from new biological insights to clinical practice

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miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13

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Regulation of microRNAs in cancer metastasis

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MicroRNA Profiling in Prostate Cancer - The Diagnostic Potential of Urinary miR-205 and miR-214

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Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes

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Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation

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p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling

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Contributions of epithelial-mesenchymal transition and cancer stem cells to the development of castration resistance of prostate cancer

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Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer

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Maintaining epithelial stemness with p63

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How theTP53Family ProteinsTP63andTP73Contribute to Tumorigenesis: Regulators and Effectors

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Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions

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miR-205 negatively regulates the androgen receptor and is associated with adverse outcome of prostate cancer patients

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Roles of microRNAs during prostatic tumorigenesis and tumor progression

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Roles of Epithelial-Mesenchymal Transition in Cancer Drug Resistance

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Molecular pathways and targets in prostate cancer

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Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer

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Co-cultivation of keratinocyte-human mesenchymal stem cell (hMSC) on sericin loaded electrospun nanofibrous composite scaffold (cationic gelatin/hyaluronan/chondroitin sulfate) stimulates epithelial differentiation in hMSCs: In vitro study

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p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer

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Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer

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Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities

Landré, V., Rotblat, B., Melino, S., Bernassola, F., & Melino, G. (2014) · Oncotarget · doi:10.18632/oncotarget.2431 · Cited by 108

MicroRNA-205, a novel regulator of the anti-apoptotic protein Bcl2, is downregulated in prostate cancer

Verdoodt, B., Neid, M., Vogt, M., KUHN, V., Liffers, S., Palisaar, R., Noldus, J., Tannapfel, A., & Mirmohammadsadegh, A. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1915 · Cited by 103

Noncoding RNAs as Novel Biomarkers in Prostate Cancer

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Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63

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Regulation of Mutant p53 Protein Expression

Vijayakumaran, R., Tan, K. H., Miranda, P. J., Haupt, S., & Haupt, Y. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00284 · Cited by 87

ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program

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miR-205-5p-mediated downregulation of ErbB/HER receptors in breast cancer stem cells results in targeted therapy resistance

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miR-205: A Potential Biomedicine for Cancer Therapy

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Leukocytes as carriers for targeted cancer drug delivery

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Bioinformatics analysis of the serine and glycine pathway in cancer cells

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miR-205 Hinders the Malignant Interplay Between Prostate Cancer Cells and Associated Fibroblasts

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p63 regulates glutaminase 2 expression

Giacobbe, A., Bongiorno‐Borbone, L., Bernassola, F., Terrinoni, A., Markert, E. K., Levine, A. J., Fen, Z., Agostini, M., Zolla, L., Finazzi‐Agrò, A., et al. (2013) · Cell Cycle · doi:10.4161/cc.24478 · Cited by 79

Transcriptional suppression of AMPKα1 promotes breast cancer metastasis upon oncogene activation

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MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

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MicroRNAs and p63 in epithelial stemness

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Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells

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Loss of miR-100 enhances migration, invasion, epithelialmesenchymal transition and stemness properties in prostate cancer cells through targeting Argonaute 2

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MiR‐301a regulates E‐cadherin expression and is predictive of prostate cancer recurrence

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MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer

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Cancer Stemness: p53 at the Wheel

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Noncoding RNAs in Prostate Cancer: The Long and the Short of It

Bolton, E. M., Tuzova, A. V., Walsh, A. L., Lynch, T. H., & Perry, A. S. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1989 · Cited by 74

Single Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the Skin

Fan, X., Wang, D., Burgmaier, J. E., Teng, Y., Romano, R., Sinha, S., & Yi, R. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.08.010 · Cited by 71

Mutant p53 Regulates Dicer through p63-dependent and -independent Mechanisms to Promote an Invasive Phenotype

Muller, P. A. J., Trinidad, A. G., Caswell, P. T., Norman, J. C., & Vousden, K. H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.502138 · Cited by 73

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

McDade, S. S., Patel, D., Moran, M., Campbell, J., Fenwick, K., Kozarewa, I., Orr, N., Lord, C. J., Ashworth, A., & McCance, D. J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku299 · Cited by 71

p63 at the Crossroads between Stemness and Metastasis in Breast Cancer

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Combination Therapy with Local Radiofrequency Ablation and Systemic Vaccine Enhances Antitumor Immunity and Mediates Local and Distal Tumor Regression

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Regulation of HMGB3 by antitumor miR-205-5p inhibits cancer cell aggressiveness and is involved in prostate cancer pathogenesis

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The role of epithelial plasticity in prostate cancer dissemination and treatment resistance

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Circulating miR-106a is a Novel Prognostic and Lymph Node Metastasis Indicator for Cholangiocarcinoma

Cheng, Q., Feng, F., Zhu, L., Zheng, Y., Luo, X., Liu, C., Yi, B., & Jiang, X. (2015) · Scientific Reports · doi:10.1038/srep16103 · Cited by 65

Pathway Regulation of p63, a Director of Epithelial Cell Fate

Yoh, K. E., & Prywes, R. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00051 · Cited by 63

Sp1-mediated transcriptional activation of miR-205 promotes radioresistance in esophageal squamous cell carcinoma

Pan, F., Mao, H., Bu, F., Tong, X., Li, J., Zhang, S., Liu, X., Wang, L., Wu, L., Chen, R., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13902 · Cited by 64

A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases

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ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes

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p63 the guardian of human reproduction

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Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness

Tamura, M., Sasaki, Y., Koyama, R., Takeda, K., Idogawa, M., & Tokino, T. (2013) · Oncogene · doi:10.1038/onc.2013.427 · Cited by 61

ΔNp63α is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis

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Unveiling the ups and downs of miR-205 in physiology and cancer: transcriptional and post-transcriptional mechanisms

Ferrari, E., & Gandellini, P. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03192-4 · Cited by 63

Alterations of p63 and p73 in Human Cancers

Inoue, K., & Fry, E. A. (2014) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-9211-0_2 · Cited by 63

MicroRNAs and epithelial-mesenchymal transition in prostate cancer

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Novel genes associated with lymph node metastasis in triple negative breast cancer

Mathe, A., Wong‐Brown, M. W., Morten, B. C., Forbes, J., Braye, S. G., Avery‐Kiejda, K. A., & Scott, R. J. (2015) · Scientific Reports · doi:10.1038/srep15832 · Cited by 58

Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer

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Long non-coding RNA SNHG1 regulates zinc finger E-box binding homeobox 1 expression by interacting with TAp63 and promotes cell metastasis and invasion in Lung squamous cell carcinoma

Zhang, H., Yang, W., Zheng, F., Wang, Y.-B., & Lu, J. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.03.104 · Cited by 56

The role of noncoding RNAs in epithelial cancer

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Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family

Kehrloesser, S., Osterburg, C., Tuppi, M., Schäfer, B., Vousden, K. H., & Dötsch, V. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.75 · Cited by 56

Direct transfection of clonal organoids in Matrigel microbeads: a promising approach toward organoid-based genetic screens

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LncRNAs and miRNAs: potential biomarkers and therapeutic targets for prostate cancer.

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Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition

Iwanicki, M., Chen, H., Iavarone, C., Zervantonakis, I. K., Muranen, T. E., Novak, M., Ince, T. A., Drapkin, R., & Brugge, J. S. (2016) · JCI Insight · doi:10.1172/jci.insight.86829 · Cited by 54

ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion

Dang, T. T., Westcott, J. M., Maine, E. A., Kanchwala, M., Xing, C., & Pearson, G. W. (2016) · Oncotarget · doi:10.18632/oncotarget.8696 · Cited by 53

Nanofibrous artificial skin substitute composed of mPEG–PCL grafted gelatin/hyaluronan/chondroitin sulfate/sericin for 2 nd degree burn care: in vitro and in vivo study

Bhowmick, S., Thanusha, A. V., Kumar, A., Scharnweber, D., Rother, S., & Koul, V. (2018) · RSC Advances · doi:10.1039/c8ra01489b · Cited by 53

The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain

D’Abramo, M., Bešker, N., Desideri, A., Levine, A. J., Melino, G., & Chillemi, G. (2015) · Oncogene · doi:10.1038/onc.2015.388 · Cited by 53

ΔNp63α activates CD82 metastasis suppressor to inhibit cancer cell invasion

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Upregulation of MiR-205 under hypoxia promotes epithelial–mesenchymal transition by targeting ASPP2

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miRNA-205 Nanoformulation Sensitizes Prostate Cancer Cells to Chemotherapy

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Caspase-1 is a novel target of p63 in tumor suppression

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Role of Epithelial Mesenchymal Transition in Prostate Tumorigenesis

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ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis

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Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis

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P63 in health and cancer

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Suppression of cell migration is promoted by miR-944 through targeting of SIAH1 and PTP4A1 in breast cancer cells

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Deregulated MicroRNAs involved in P53 Signaling Pathway in Breast Cancer with Focus on Triple-negative Breast Cancer

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Circulating Long Noncoding RNA as a Potential Target for Prostate Cancer

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TP53 Mutants in the Tower of Babel of Cancer Progression

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MiR-205 Is Progressively Down-Regulated in Lymph Node Metastasis but Fails as a Prognostic Biomarker in High-Risk Prostate Cancer

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Syndecan-1 up-regulates microRNA-331-3p and mediates epithelial-to-mesenchymal transition in prostate cancer

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MicroRNAs as Key Effectors in the p53 Network

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Activation of miR200 by c-Myb depends on ZEB1 expression and miR200 promoter methylation

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TAp63 suppress metastasis via miR-133b in colon cancer cells

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Micro RNA (miR)‐203 and miR‐205 expression patterns identify subgroups of prognosis in cutaneous squamous cell carcinoma

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p63 controls cell migration and invasion by transcriptional regulation of MTSS1

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The Interactions of microRNA and Epigenetic Modifications in Prostate Cancer

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Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy

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MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary

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MicroRNA‑16‑5p regulates cell survival, cell cycle and apoptosis by targeting AKT3 in prostate cancer cells

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Loss of p63 and its miR-205 target results in enhanced cell migration and metastasis in prostate cancer

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miR-573 inhibits prostate cancer metastasis by regulating epithelial-mesenchymal transition

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miR-135b inhibits tumour metastasis in prostate cancer by targeting STAT6

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Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis

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MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines

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