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Cited by 198

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

The chromatin insulator CTCF and the emergence of metazoan diversity

Open access
Heger, Peter, Marin, Birger, Bartkuhn, Marek, Schierenberg, Einhard, Wiehe, Thomas·2012·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1111941109
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Abstract

The great majority of metazoans belong to bilaterian phyla. They diversified during a short interval in Earth’s history known as the Cambrian explosion, ∼540 million years ago. However, the genetic basis of these events is poorly understood. Here we argue that the vertebrate genome organizer CTCF (CCCTC-binding factor) played an important role for the evolution of bilaterian animals. We provide evidence that the CTCF protein and a genome-wide abundance of CTCF-specific binding motifs are unique to bilaterian phyla, but absent in other eukaryotes. We demonstrate that CTCF-binding sites within vertebrate and Drosophila Hox gene clusters have been maintained for several hundred million years, suggesting an ancient origin of the previously known interaction between Hox gene regulation and CTCF. In addition, a close correlation between the presence of CTCF and Hox gene clusters throughout the animal kingdom suggests conservation of the Hox-CTCF link across the Bilateria. On the basis of these findings, we propose the existence of a Hox-CTCF kernel as principal organizer of bilaterian body plans. Such a kernel could explain ( i ) the formation of Hox clusters in Bilateria, ( ii ) the diversity of bilaterian body plans, and ( iii ) the uniqueness and time of onset of the Cambrian explosion.

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Metadata

Authors
Heger, P., Marin, B., Bartkuhn, M., Schierenberg, E., & Wiehe, T.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2012-10-08
Volume
109
Issue
43
Pages
17507-17512
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1111941109
OpenAlex
W2067686625
Cited by
198
References
26
FWCI
2.21
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The chromatin insulator CTCF and the emergence of metazoan diversity. https://app.cochat.ai/papers/10.1073/pnas.1111941109
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Heger, P., Marin, B., Bartkuhn, M., Schierenberg, E., & Wiehe, T. (2012). The chromatin insulator CTCF and the emergence of metazoan diversity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1111941109

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.