The origin of Metazoa: a unicellular perspective

Topological domains in mammalian genomes identified by analysis of chromatin interactions

Dixon, J. R., Selvaraj, S., Yue, F., Kim, A., Li, Y., Shen, Y., Hu, M., Liu, J. S., & Ren, B. (2012) · Nature · doi:10.1038/nature11082 · Cited by 6,829 · see citing works

Spatial partitioning of the regulatory landscape of the X-inactivation centre

Nora, E. P., Lajoie, B. R., Schulz, E. G., Giorgetti, L., Okamoto, I., Servant, N., Piolot, T., van Berkum, N. L., Meisig, J., Sedat, J., et al. (2012) · Nature · doi:10.1038/nature11049 · Cited by 2,895 · see citing works

An atlas of active enhancers across human cell types and tissues

The FANTOM Consortium, Andersson, R., Gebhard, C., Miguel-Escalada, I., Hoof, I., Bornholdt, J., Boyd, M., Chen, Y., Zhao, X., Schmidl, C., et al. (2014) · Nature · doi:10.1038/nature12787 · Cited by 2,550 · see citing works

Histone modifications at human enhancers reflect global cell-type-specific gene expression

Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature · doi:10.1038/nature07829 · Cited by 2,533 · see citing works

A unique chromatin signature uncovers early developmental enhancers in humans

Rada-Iglesias, A., Bajpai, R., Swigut, T., Brugmann, S. A., Flynn, R. A., & Wysocka, J. (2011) · Nature · doi:10.1038/nature09692 · Cited by 2,233 · see citing works

Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization

Putnam, N. H., Srivastava, M., Hellsten, U., Dirks, B., Chapman, J., Salamov, A., Terry, A., Shapiro, H., Lindquist, E., Kapitonov, V. V., et al. (2007) · Science · doi:10.1126/science.1139158 · Cited by 1,555 · see citing works

The Cambrian Conundrum: Early Divergence and Later Ecological Success in the Early History of Animals

Erwin, D. H., Laflamme, M., Tweedt, S. M., Sperling, E. A., Pisani, D., & Peterson, K. J. (2011) · Science · doi:10.1126/science.1206375 · Cited by 1,336 · see citing works

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., et al. (2008) · Nature · doi:10.1038/nature06617 · Cited by 1,139 · see citing works

The Amphimedon queenslandica genome and the evolution of animal complexity

Srivastava, M., Simakov, O., Chapman, J., Fahey, B., Gauthier, M. E. A., Mitros, T., Richards, G. S., Conaco, C., Dacre, M., Hellsten, U., et al. (2010) · Nature · doi:10.1038/nature09201 · Cited by 1,049 · see citing works

Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor

Deng, W., Lee, J., Wang, H., Miller, J., Reik, A., Gregory, P. D., Dean, A., & Blobel, G. A. (2012) · Cell · doi:10.1016/j.cell.2012.03.051 · Cited by 734 · see citing works

Fossil steroids record the appearance of Demospongiae during the Cryogenian period

Love, G. D., Grosjean, E., Stalvies, C., Fike, D. A., Grotzinger, J. P., Bradley, A. S., Kelly, A. E., Bhatia, M., Meredith, W., Snape, C. E., et al. (2009) · Nature · doi:10.1038/nature07673 · Cited by 731 · see citing works

The ctenophore genome and the evolutionary origins of neural systems

Moroz, L. L., Kocot, K. M., Citarella, M. R., Dosung, S., Norekian, T. P., Povolotskaya, I. S., Grigorenko, A. P., Dailey, C., Berezikov, E., Buckley, K. M., et al. (2014) · Nature · doi:10.1038/nature13400 · Cited by 716 · see citing works

The Genome of the Ctenophore <i>Mnemiopsis leidyi</i> and Its Implications for Cell Type Evolution

Ryan, J. F., Pang, K., Schnitzler, C. E., Nguyen, A.-D., Moreland, R. T., Simmons, D. K., Koch, B. J., Francis, W. R., Havlak, P., Program, N. C. S., et al. (2013) · Science · doi:10.1126/science.1242592 · Cited by 702 · see citing works

The evolution of cell types in animals: emerging principles from molecular studies

Arendt, D. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2416 · Cited by 525 · see citing works

A Large and Consistent Phylogenomic Dataset Supports Sponges as the Sister Group to All Other Animals

Simion, P., Philippe, H., Baurain, D., Jager, M., Richter, D. J., Di Franco, A., Roure, B., Satoh, N., Quéinnec, É., Ereskovsky, A., et al. (2017) · Current Biology · doi:10.1016/j.cub.2017.02.031 · Cited by 518 · see citing works

C2H2 zinc finger proteins greatly expand the human regulatory lexicon

Najafabadi, H. S., Mnaimneh, S., Schmitges, F. W., Garton, M., Lam, K. N., Yang, A., Albu, M., Weirauch, M. T., Radovani, E., Kim, P. M., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3128 · Cited by 346 · see citing works

Six major steps in animal evolution: Are we derived sponge larvae?

Nielsen, C. (2008) · Evolution &amp; Development · doi:10.1111/j.1525-142x.2008.00231.x · Cited by 343 · see citing works

Error, signal, and the placement of Ctenophora sister to all other animals

Whelan, N. V., Kocot, K. M., Moroz, L. L., & Halanych, K. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503453112 · Cited by 331 · see citing works

The Closest Unicellular Relatives of Animals

Lang, B. F., O'Kelly, C., Nerad, T., Gray, M. W., & Burger, G. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01187-9 · Cited by 326 · see citing works

The Capsaspora genome reveals a complex unicellular prehistory of animals

Suga, H., Chen, Z., de Mendoza, A., Sebé-Pedrós, A., Brown, M. W., Kramer, E., Carr, M., Kerner, P., Vervoort, M., Sánchez-Pons, N., et al. (2013) · Nature Communications · doi:10.1038/ncomms3325 · Cited by 317 · see citing works

The Ediacaran emergence of bilaterians: congruence between the genetic and the geological fossil records

Peterson, K. J., Cotton, J. A., Gehling, J. G., & Pisani, D. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2007.2233 · Cited by 313 · see citing works

A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals

Alegado, R. A., Brown, L. W., Cao, S., Dermenjian, R. K., Zuzow, R., Fairclough, S. R., Clardy, J., & King, N. (2012) · eLife · doi:10.7554/elife.00013 · Cited by 249 · see citing works

The evolutionary history of haptophytes and cryptophytes: phylogenomic evidence for separate origins

Burki, F., Okamoto, N., Pombert, J.-F., & Keeling, P. J. (2012) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2011.2301 · Cited by 240 · see citing works

The Genomic and Cellular Foundations of Animal Origins

Richter, D. J., & King, N. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133456 · Cited by 196 · see citing works

Phylogenetic Relationships within the Opisthokonta Based on Phylogenomic Analyses of Conserved Single-Copy Protein Domains

Torruella, G., Derelle, R., Paps, J., Lang, B. F., Roger, A. J., Shalchian-Tabrizi, K., & Ruiz-Trillo, I. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/msr185 · Cited by 169 · see citing works

Developmental gene expression provides clues to relationships between sponge and eumetazoan body plans

Leininger, S., Adamski, M., Bergum, B., Guder, C., Liu, J., Laplante, M., Bråte, J., Hoffmann, F., Fortunato, S., Jordal, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4905 · Cited by 136 · see citing works

Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution

Arendt, D., Benito-Gutierrez, E., Brunet, T., & Marlow, H. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0286 · Cited by 112 · see citing works

Physico-Genetic Determinants in the Evolution of Development

Newman, S. A. (2012) · Science · doi:10.1126/science.1222003 · Cited by 92 · see citing works

The origin of animal body plans: a view from fossil evidence and the regulatory genome

Erwin, D. H. (2020) · Development · doi:10.1242/dev.182899 · Cited by 133 · see citing works

Cell death by phagocytosis

Brown, G. C. (2024) · Nature Reviews Immunology · doi:10.1038/s41577-023-00921-6 · Cited by 129 · see citing works

The architecture of cell differentiation in choanoflagellates and sponge choanocytes

Laundon, D., Larson, B. T., McDonald, K., King, N., & Burkhardt, P. (2019) · PLOS Biology · doi:10.1371/journal.pbio.3000226 · Cited by 93 · see citing works

Early animal evolution: a morphologist's view

Nielsen, C. (2019) · Royal Society Open Science · doi:10.1098/rsos.190638 · Cited by 77 · see citing works

A non-bilaterian perspective on the development and evolution of animal digestive systems

Steinmetz, P. R. H. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03075-x · Cited by 67 · see citing works

Cadherins in early neural development

Punovuori, K., Malaguti, M., & Lowell, S. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03815-9 · Cited by 39 · see citing works

The Origin of Metazoan Multicellularity: A Potential Microbial Black Swan Event

Ruiz-Trillo, I., Kin, K., & Casacuberta, E. (2023) · Annual Review of Microbiology · doi:10.1146/annurev-micro-032421-120023 · Cited by 36 · see citing works

Fundamental constraints to the logic of living systems

Solé, R., Kempes, C. P., Corominas-Murtra, B., De Domenico, M., Kolchinsky, A., Lachmann, M., Libby, E., Saavedra, S., Smith, E., & Wolpert, D. (2024) · Interface Focus · doi:10.1098/rsfs.2024.0010 · Cited by 34 · see citing works

The road to synthetic multicellularity

Solé, R., Ollé-Vila, A., Vidiella, B., Duran-Nebreda, S., & Conde-Pueyo, N. (2018) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2017.11.007 · Cited by 19 · see citing works