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Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior
Open accessAbstract
Fifty years ago, increased whole-blood serotonin levels, or hyperserotonemia, first linked disrupted 5-HT homeostasis to Autism Spectrum Disorders (ASDs). The 5-HT transporter (SERT) gene ( SLC6A4 ) has been associated with whole blood 5-HT levels and ASD susceptibility. Previously, we identified multiple gain-of-function SERT coding variants in children with ASD. Here we establish that transgenic mice expressing the most common of these variants, SERT Ala56, exhibit elevated, p38 MAPK-dependent transporter phosphorylation, enhanced 5-HT clearance rates and hyperserotonemia. These effects are accompanied by altered basal firing of raphe 5-HT neurons, as well as 5HT 1A and 5HT 2A receptor hypersensitivity. Strikingly, SERT Ala56 mice display alterations in social function, communication, and repetitive behavior. Our efforts provide strong support for the hypothesis that altered 5-HT homeostasis can impact risk for ASD traits and provide a model with construct and face validity that can support further analysis of ASD mechanisms and potentially novel treatments.
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In the citing paper
“as well as altered basal firing of DR 5-HT neurons [120,121].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [120]
In the citing paper
“mice expressing a gain-of-function SERT variant that decreases 5-HT levels exhibit impaired sociability”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [120]
In the citing paper
“SERT Ala56 mice exhibit whole-blood hyperserotonemia as well as brain and behavioral anomalies”
From Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders (2018) · cites this paper as [55]
In the citing paper
“behavioral anomalies emulating those in ASD including repetitive behaviors, delayed communication and deficits in social interactions [55].”
From Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders (2018) · cites this paper as [55]
In the citing paper
“including increased 5-HT clearance in the CNS, hypersensitivity of CNS 5-HT1A and 5-HT2A receptors”
From Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders (2018) · cites this paper as [55]
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Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Abràmoff, M. D., Magalhães, P. J., & Ram, S. J. (2004) · Utrecht University Repository (Utrecht University) · Cited by 11,816
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
American Psychiatric Association (2000) · doi:10.1176/appi.books.9780890423349 · Cited by 11,069
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters
Yamashita, A., Singh, S. K., Kawate, T., Jin, Y., & Gouaux, E. (2005) · Nature · doi:10.1038/nature03978 · Cited by 1,660
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
Peça, J., Feliciano, C., Ting, J. T., Wang, W., Wells, M. F., Venkatraman, T. N., Lascola, C. D., Fu, Z., & Feng, G. (2011) · Nature · doi:10.1038/nature09965 · Cited by 1,570
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,522
Self-citationBehavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462
Self-citationPeñagarikano, O., Abrahams, B. S., Herman, E. I., Winden, K. D., Gdalyahu, A., Dong, H., Sonnenblick, L. I., Gruver, R., Almajano, J., Bragin, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.040 · Cited by 1,075
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M., & Südhof, T. C. (2007) · Science · doi:10.1126/science.1146221 · Cited by 997
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Sleep Problems in Children with ASD and Gene Disrupting Mutations
Earl, R. K., Ward, T., Gerdts, J. A., Eichler, E. E., Bernier, R., & Hudac, C. M. (2021) · The Journal of Genetic Psychology · doi:10.1080/00221325.2021.1922869 · Cited by 15
Ye, R., Quinlan, M. A., Iwamoto, H., Wu, H., Green, N. H., Jetter, C. S., McMahon, D. G., Veenstra-VanderWeele, J. M., Levitt, P. R., & Blakely, R. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2015.00020 · Cited by 15
Self-citationEllenbroek, B. A., August, C. L., & Youn, J. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00424 · Cited by 12
Autism, youth suicide, and psychedelics: A review of the 21st century evidence
Chen, M., Su, T., Hsu, J.-W., & Tsai, S. (2024) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000001150 · Cited by 14
Steinman, G. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.03.034 · Cited by 14
Role of Biomarkers in Medicine
Wang, M., & Witzmann, F. A. (2016) · InTech eBooks · doi:10.5772/61449 · Cited by 16
Luhach, K., Kulkarni, G. T., Singh, V. P., & Sharma, B. (2021) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13459 · Cited by 14
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Asta, L., Ricciardello, A., Cucinotta, F., Turriziani, L., Boncoddo, M., Bellomo, F., Angelini, J. M., Gnazzo, M., Scandolo, G., Pisanò, G., et al. (2024) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-024-09572-7 · Cited by 14
Ye, R., Carneiro, A. M. D., Han, Q., Airey, D., Sanders‐Bush, E., Zhang, B., Lü, L., Williams, R. W., & Blakely, R. (2014) · Genes Brain & Behavior · doi:10.1111/gbb.12119 · Cited by 12
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Ehlinger, D. G., & Commons, K. G. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13707 · Cited by 13
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Lương, K. V. Q. (2013) · American Journal of Psychiatry and Neuroscience · doi:10.11648/j.ajpn.20130102.11 · Cited by 10
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Coke-Murphy, C., Buendia, M. A., Saborido, T. P., & Stanwood, G. D. (2014) · Translational Neuroscience · doi:10.2478/s13380-014-0228-4 · Cited by 9
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Daly, E., Tricklebank, M. D., & Wichers, R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813323-1.00002-5 · Cited by 11
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Ritter, K., Buehler, D. P., Asher, S. B., Deal, K. K., Zhao, S., Guo, Y. P., & Southard‐Smith, E. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136838 · Cited by 9
Whitaker‐Azmitia, P. M. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00023-2 · Cited by 9
O’Reilly, K. C., Anacker, A. M. J., Rogers, T. D., Forsberg, C. G., Wang, J., Zhang, B., Blakely, R. D., & Veenstra-VanderWeele, J. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135027 · Cited by 8
Self-citationCheng, Y., Zhang, L., Li, Y., Zheng, C., Ma, T., & Sun, Z. (2026) · Microorganisms · doi:10.3390/microorganisms14020312 · Cited by 10
Gajewski-Kurdziel, P. A., Walsh, A. E., & Blakely, R. (2024) · Current Research in Physiology · doi:10.1016/j.crphys.2024.100117 · Cited by 8
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Vannucchi, G., Perugi, G., & Masi, G. (2019) · Springer eBooks · doi:10.1007/978-3-030-26276-1_7 · Cited by 8
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Chen, K., Kardys, A., Chen, Y., Flink, S. C., Tabakoff, B., & Shih, J. C. (2017) · Brain Research · doi:10.1016/j.brainres.2017.05.017 · Cited by 8
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Cascio, C. J., Simon, D. M., Bryant, L. K., DiCarlo, G. E., & Wallace, M. T. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812492-5.00017-6 · Cited by 11
Petrinovic, M. M., & Künnecke, B. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3200-z · Cited by 8
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Petroccione, M. A., D’Brant, L. Y., Affinnih, N., Wehrle, P. H., Todd, G. C., Zahid, S., Chesbro, H. E., Tschang, I. L., & Scimemi, A. (2023) · eLife · doi:10.7554/elife.81830 · Cited by 6
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Blakely, R., Mestikawy, S. E., & Robinson, M. B. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.12.006 · Cited by 5
Self-citationO’Connell, C. J., Reeder, E. L., Hymore, J. A., Brown, R. S., Notorgiacomo, G. A., Collins, S. M., Gudelsky, G. A., & Robson, M. J. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114695 · Cited by 5
Hosseini, K., Cediel-Ulloa, A., Al-Sabri, M. H., Forsby, A., & Fredriksson, R. (2024) · Pharmaceuticals · doi:10.3390/ph17101392 · Cited by 5
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Greene, S. M., Sanchez, Y. R., Pathapati, N., Davis, G. N., & Gould, G. G. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104919 · Cited by 5
Meinke, C., Quinlan, M. A., Paffenroth, K. C., Harrison, F. E., Fenollar‐Ferrer, C., Katamish, R. M., Stillman, I., Ramamoorthy, S., & Blakely, R. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03299-w · Cited by 5
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Benza, N., & Chugani, D. C. (2015) · Contemporary clinical neuroscience · doi:10.1007/978-1-4939-2190-4_13 · Cited by 5
Puzerey, P. A., Kodama, N. X., & Galán, R. F. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00996.2014 · Cited by 6
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Lawrence, R. H., Palumbo, M., Freeman, S. M., Guoynes, C. D., & Bales, K. L. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.584731 · Cited by 6
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Ro, M., Won, S., Kang, H., Kim, S., Lee, S. K., Nam, M., Bang, H. J., Yang, J. W., Choi, K.-S., Kim, S. K., et al. (2013) · Neuropsychobiology · doi:10.1159/000355299 · Cited by 5
Béroule, D. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.585395 · Cited by 4
Goto, S., Ogi, H., Fushiki, S., & Itoh, K. (2017) · Brain and Development · doi:10.1016/j.braindev.2017.01.007 · Cited by 4
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Tamada, K., & Takumi, T. (2014) · Neuromethods · doi:10.1007/978-1-4939-2250-5_9 · Cited by 4
Sealover, N. R., Felts, B., Kuntz, C. P., Jarrard, R. E., Hockerman, G. H., Barker, E. L., & Henry, L. K. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.09.006 · Cited by 4
Jayanthi, L. D., & Ramamoorthy, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167713 · Cited by 4
Self-citationAnalysis of neuronal activity impairment in iPSC-derived neurons from idiopathic autism patients
Kern, A., Román, V., Orbán, T. I., Pál, I., Nagy, J., Lévay, G. I., Lendvai, B., & Némethy, Z. (2025) · iScience · doi:10.1016/j.isci.2025.113615 · Cited by 3
Creighton, S. D., Palmer, D. D., Mitchnick, K. A., & Winters, B. D. (2018) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-812012-5.00006-9 · Cited by 4
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Palacios-Avendaño, N., Rojas, P. S., Alarcón-Mardones, M., & Fiedler, J. L. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1800447 · Cited by 4
Wang, T., & Wöhr, M. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106747 · Cited by 2
Niego, A., & Benítez‐Burraco, A. (2022) · Biolinguistics · doi:10.5964/bioling.9319 · Cited by 3
Luhach, K., Sharma, P., Sharma, N., Dhiman, N., Kharkwal, H., & Sharma, B. (2023) · Springer eBooks · doi:10.1007/978-3-031-42383-3_3 · Cited by 3
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Shen, J., Gao, J., Gao, L., Yan, D., Wang, Y., Meng, J., Li, H., Chen, D., & Wu, J. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06163-8 · Cited by 1
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Ahmadi, S. A. Y., Almasian, M., & Rezaian, J. (2016) · Cited by 1
Castejón, O. J. (2019) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2019.19.003321 · Cited by 1
Shah, F., & Dwivedi, M. (2022) · Springer eBooks · doi:10.1007/978-981-16-6760-2_4 · Cited by 1
Bolivar, V. J. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.012 · Cited by 1
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RetractedBrusco, A., & Ferrero, G. B. (2019) · Springer eBooks · doi:10.1007/978-3-030-26276-1_2 · Cited by 2
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Anderson, G. M. (2014) · Wiley eBooks · doi:10.1002/9781118911389.hautc19 · Cited by 1
Nackenoff, A. (2016) · Cited by 1
Niego, A., & Benítez‐Burraco, A. (2021) · Biolinguistics · doi:10.31234/osf.io/wh9qe · Cited by 1
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DeFilippis, B., Romano, E., & Laviola, G. (2013) · Springer eBooks · doi:10.1007/978-1-4614-4788-7_104
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Kazek, B., Jamroz, E., Kajor, M., Grzybowska‐Chlebowczyk, U., Ciupińska-Kajor, M., & Woś, H. (2013) · Pediatria Polska · doi:10.1016/j.pepo.2013.03.005
Gomez‐Mancilla, B. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004017
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Pietropaolo, S., Sluyter, F., & Crusio, W. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.010
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Puzerey, P. A. (2015) · OhioLink ETD Center (Ohio Library and Information Network)
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Scattoni, M. L., Michetti, C., Caruso, A., & Ricceri, L. (2017) · Wiley eBooks · doi:10.1002/9781118540770.ch11
Ruiz, K. P. G. (2014) · Gredos (University of Salamanca) · doi:10.14201/gredos.127388
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Geller, B. (2012) · Journal watch · doi:10.1056/jp201204230000004
Budylin, T. (2019) · CUNY Academic Works (City University of New York)
Metadata
- Authors
- Veenstra-VanderWeele, J., Muller, C. L., Iwamoto, H., Sauer, J. E., Owens, W. A., Shah, C. R., Cohen, J., Mannangatti, P., Jessen, T., Thompson, B. J., Ye, R., Kerr, T. M., Carneiro, A. M., Crawley, J. N., Sanders-Bush, E., McMahon, D. G., Ramamoorthy, S., Daws, L. C., Sutcliffe, J. S., & Blakely, R. D.
- Affiliations
- Vanderbilt University (US)
- The University of Texas at San Antonio Health Science Center (US)
- National Institutes of Health (US)
- Departments of aPsychiatry,
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-03-19
- Volume
- 109
- Issue
- 14
- Pages
- 5469-5474
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3325657
- OpenAlex
- W2104220482
- Cited by
- 333
- References
- 76
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 18 · 2023: 17 · 2022: 21 · 2021: 26 · 2020: 20 · 2019: 25 · 2018: 23 · 2017: 27 · 2016: 33 · 2015: 23 · 2014: 29 · 2013: 33 · 2012: 18
- FWCI
- 16.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Autism Speaks (AS2429)
- Vanderbilt University (HD15052)
- Vanderbilt Institute for Clinical and Translational Research (RR024975)
- H. Lundbeck A/S
- National Institutes of Health (HD-15052, RR024975)
- Vanderbilt Kennedy Center, Vanderbilt University Medical Center
- National Institute of Mental Health (R01MH094527, K08MH081066, MH081066, MH078098, R01MH062612, MH094604, MH-62612, R01MH094604, R03MH078098)
- National Institute on Drug Abuse (DA-07390, R01DA007390)
- National Center for Research Resources (RR024975, KL2RR024977, TL1RR024978, UL1RR024975)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD015052, HD 15052, HD065278, R01HD065278)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- autism spectrum disorder, hyperserotonemia, serotonin transporter, gain-of-function mutations, p38 MAPK, serotonin clearance, raphe neurons, 5-HT1A receptor, 5-HT2A receptor, receptor hypersensitivity, social dysfunction, repetitive behavior, transgenic mouse model
- MeSH terms
- Animals, Autistic Disorder, Disease Models, Animal, Homeostasis, Receptors, Serotonin, Serotonin, Social Behavior, Stereotyped Behavior, Mice
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