Behavioural phenotyping assays for mouse models of autism
Open accessAbstract
Autism is a heterogeneous neurodevelopmental disorder of unknown aetiology that affects 1 in 100-150 individuals. Diagnosis is based on three categories of behavioural criteria: abnormal social interactions, communication deficits and repetitive behaviours. Strong evidence for a genetic basis has prompted the development of mouse models with targeted mutations in candidate genes for autism. As the diagnostic criteria for autism are behavioural, phenotyping these mouse models requires behavioural assays with high relevance to each category of the diagnostic symptoms. Behavioural neuroscientists are generating a comprehensive set of assays for social interaction, communication and repetitive behaviours to test hypotheses about the causes of autism. Robust phenotypes in mouse models hold great promise as translational tools for discovering effective treatments for components of autism spectrum disorders.
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Measures of sociability generated in the three-chamber assay have been interpreted as an all-or-none result that should be restricted to comparison with a single experimental group, rather than a comparison between groups.
“The measures of sociability generated in the three chamber assay have been interpreted as an all-or-none result that should be restricted to comparison with a single experimental group, rather than a comparison between groups [7].”
From Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders (2016) · cites this paper as [7]
The Social approach section defines sociability by comparing time spent with a mouse versus an object, but does not say the result is all-or-none or must be confined to a single group. The Sample sizes and statistical analyses section instead recommends comparing group means to identify differences between genotypes or treatments; page numbers were not available in our copy. (LLM, conf=0.84)
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Experimental — accuracy not yet measuredThe majority of ASD preclinical research has been carried out in mouse models that utilize standardized behavioral phenotyping tools to measure ASD-relevant deficits in social behavior, screen for repetitive behaviors and restricted interests, and evaluate associated symptoms, such as anxiety.
“The majority of ASD preclinical research has been carried out in mouse models that utilize standardized behavioral phenotyping tools to measure ASD-relevant deficits in social behavior, screen for repetitive behaviors and restricted interests, and evaluate associated symptoms, such as anxiety [7].”
From Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders (2016) · cites this paper as [7]
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Experimental — accuracy not yet measuredMouse models of ASD with deficits in up to three core behavioral domains approximate ASDs in tasks such as social approach, ultrasonic vocalizations, and repetitive motor behaviors.
“Mouse models of ASD, with deficits in up to three core behavioral domains, have begun to approximate ASDs in newly developed behavioral tasks, such as social approach, ultrasonic vocalizations and measurements of repetitive motor behaviors79.”
From Dendritic spine pathology in neuropsychiatric disorders (2011) · cites this paper as [79]
None of the various social and communication behaviors have been validated as robustly translatable from rodents to humans.
“However, to date none of the various social and communication behaviors have been validated as robustly translatable from rodents to humans (Silverman et al., 2010).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Silverman et al., 2010
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- Authors
- Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N.
- Affiliations
- National Institute of Mental Health (US)
- University of Michigan (US)
- Corresponding author
- Crawley, Jacqueline N.
- Venue
- Nature Reviews Neuroscience
- Published
- 2010-07
- Volume
- 11
- Issue
- 7
- Pages
- 490-502
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3087436
- OpenAlex
- W2098277878
- Cited by
- 1,462
- References
- 181
- Citations by year
- 2026: 52 · 2025: 74 · 2024: 109 · 2023: 77 · 2022: 116 · 2021: 121 · 2020: 125 · 2019: 108 · 2018: 113 · 2017: 94 · 2016: 101 · 2015: 91 · 2014: 78 · 2013: 66 · 2012: 75
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5rc1mh089721-02)
- National Institute of Mental Health (RC1 MH-089721, MH02179, R01MH089390, Z01MH002179, R01MH81873, 1RC1MH089721, ZIAMH002179, R01MH081873)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, mouse models of autism, behavioral phenotyping, behavioural assays, social interaction deficits, communication difficulties, repetitive behavior, candidate gene mutations, translational research, neurodevelopmental disorders
- MeSH terms
- Animals, Autistic Disorder, Disease Models, Animal, Diseases in Twins, Humans, Interpersonal Relations, Mutation, Phenotype, Social Behavior Disorders, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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