The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Critical role for calcium mobilization in activation of the NLRP3 inflammasome
Open accessAbstract
The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome mediates production of inflammatory mediators, such as IL-1β and IL-18, and as such is implicated in a variety of inflammatory processes, including infection, sepsis, autoinflammatory diseases, and metabolic diseases. The proximal steps in NLRP3 inflammasome activation are not well understood. Here we elucidate a critical role for Ca 2+ mobilization in activation of the NLRP3 inflammasome by multiple stimuli. We demonstrate that blocking Ca 2+ mobilization inhibits assembly and activation of the NLRP3 inflammasome complex, and that during ATP stimulation Ca 2+ signaling is pivotal in promoting mitochondrial damage. C/EPB homologous protein, a transcription factor that can modulate Ca 2+ release from the endoplasmic reticulum, amplifies NLRP3 inflammasome activation, thus linking endoplasmic reticulum stress to activation of the NLRP3 inflammasome. Our findings support a model for NLRP3 inflammasome activation by Ca 2+ -mediated mitochondrial damage.
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Cites
Origin and physiological roles of inflammation
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A role for mitochondria in nlrp3 inflammasome activation
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
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Cryopyrin activates the inflammasome in response to toxins and ATP
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
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Cited by
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
Swanson, K. V., Deng, M., & Ting, J. P.-Y. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0165-0 · Cited by 4,884
The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation
Kelley, N., Jeltema, D., Duan, Y., & He, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133328 · Cited by 3,539
Inflammasomes: mechanism of action, role in disease, and therapeutics
Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340
Activation and regulation of the inflammasomes
Latz, E., Xiao, T. S., & Stutz, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3452 · Cited by 2,884
Mechanism and Regulation of NLRP3 Inflammasome Activation
He, Y., Hara, H., & Núñez, G. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.09.002 · Cited by 2,759
Metadata
- Authors
- Murakami, T., Ockinger, J., Yu, J., Byles, V., McColl, A., Hofer, A. M., & Horng, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-06-25
- Volume
- 109
- Issue
- 28
- Pages
- 11282-11287
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2037600884
- Cited by
- 923
- References
- 13
- FWCI
- 15.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Murakami, T., Ockinger, J., Yu, J., Byles, V., McColl, A., Hofer, A. M., & Horng, T. (2012). Critical role for calcium mobilization in activation of the NLRP3 inflammasome. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1117765109
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