Functional organization of the insula and inner perisylvian regions
Open accessAbstract
In the last few years, the insula has been the focus of many brain-imaging studies, mostly devoted to clarify its role in emotions and social communication. Physiological data, however, on which one may ground these correlative findings are almost totally lacking. Here, we investigated the functional properties of the insular cortex in behaving monkeys using intracortical microstimulation. Behavioral responses and heart rate changes were recorded. The results showed that the insula is functionally formed by two main subdivisions: ( i ) a sensorimotor field occupying the caudal–dorsal portion of the insula and appearing as an extension of the parietal lobe; and ( ii ) a mosaic of orofacial motor programs located in the anterior and centroventral insula sector. These programs show a progressive shift from dorsally located nonemotional motor programs (ingestive activity) to ventral ones laden with emotional and communicative content. The relationship between ingestive and other behaviors is discussed in an evolutionary perspective.
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The insula could be involved in articulation and could be part of the corollary discharge circuit.
“Nevertheless, other research suggests that the insula could be involved in articulation and could be part of the corollary discharge circuit.”
From Bridging phenomenology and neural mechanisms of inner speech: ALE meta-analysis on egocentricity and spontaneity in a dual-mechanistic framework (2023) · cites this paper as Jezzini et al., 2012
The Discussion describes orofacial motor programs in the anterior and centroventral insula, and Some Evolutionary Considerations proposes a possible link to the movements needed for speech articulation (page numbers unavailable). Our copy does not identify the insula as part of a corollary discharge circuit. (LLM, conf=0.84)
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Cites
How do you feel — now? The anterior insula and human awareness
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“The work by Craig (1), for example, claims that the insula is involved in maternal love, bowel distention, orgasm, sudden insight, and decision making as well as awareness and consciousness (2).”
BackgroundThe role of anterior insular cortex in social emotions
Lamm, C., & Singer, T. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0251-3 · Cited by 566 · see citing works
The yin and yang of cardiac autonomic control: Vago-sympathetic interactions revisited
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Functional neuroanatomy of the insular lobe
Stephani, C., Fernandez-Baca Vaca, G., Maciunas, R., Koubeissi, M., & Lüders, H. O. (2011) · Brain Structure and Function · doi:10.1007/s00429-010-0296-3 · Cited by 251 · see citing works
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Research works printed but not linked: 1
- Gothard K, Hoffman K (2010) Circuits of emotion in the primate brain. Primate Neuroethology, eds Platt M, Ghazanfar A (Oxford University Press, New York), pp 292-315.
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Evolution of behavioural control from chordates to primates
Cisek, P. (2022) · Philosophical Transactions of the Royal Society B · doi:10.1098/rstb.2020.0522 · Cited by 107 · see citing works
van Elk, M., Lenggenhager, B., Heydrich, L., & Blanke, O. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.03.004 · Cited by 53 · see citing works
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“For example, a study of macaques showed that stimulation of the insula triggers orofacial motor programmes such as chewing, mouthing, lip smacking and swallowing (Jezzini et al., 2012).”
BackgroundTouching moments: desire modulates the neural anticipation of active romantic caress
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Cortico-spinal modularity in the parieto-frontal system: A new perspective on action control
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- Authors
- Jezzini, A., Caruana, F., Stoianov, I., Gallese, V., & Rizzolatti, G.
- Affiliations
- University of Parma (IT)
- Dipartimento di Neuroscienze, Università di Parma, 43100 Parma, Italy;
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-05-30
- Volume
- 109
- Issue
- 25
- Pages
- 10077-10082
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3382514
- OpenAlex
- W2112263359
- Cited by
- 152
- References
- 4
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 6 · 2023: 20 · 2022: 4 · 2021: 12 · 2020: 12 · 2019: 9 · 2018: 16 · 2017: 17 · 2016: 12 · 2015: 8 · 2014: 9 · 2013: 13 · 2012: 1
- FWCI
- 14.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Topics
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- insula, intracortical microstimulation, sensorimotor cortex, ingestive behavior, emotional behavior, social communication, heart rate, parietal lobe, primate cortex, evolution of behavior
- MeSH terms
- Animals, Behavior, Animal, Cerebral Cortex, Macaca mulatta
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