The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Root gravitropism is regulated by a transient lateral auxin gradient controlled by a tipping-point mechanism
Open accessAbstract
Gravity profoundly influences plant growth and development. Plants respond to changes in orientation by using gravitropic responses to modify their growth. Cholodny and Went hypothesized over 80 years ago that plants bend in response to a gravity stimulus by generating a lateral gradient of a growth regulator at an organ's apex, later found to be auxin. Auxin regulates root growth by targeting Aux/IAA repressor proteins for degradation. We used an Aux/IAA-based reporter, domain II (DII)-VENUS, in conjunction with a mathematical model to quantify auxin redistribution following a gravity stimulus. Our multidisciplinary approach revealed that auxin is rapidly redistributed to the lower side of the root within minutes of a 90° gravity stimulus. Unexpectedly, auxin asymmetry was rapidly lost as bending root tips reached an angle of 40° to the horizontal. We hypothesize roots use a “tipping point” mechanism that operates to reverse the asymmetric auxin flow at the midpoint of root bending. These mechanistic insights illustrate the scientific value of developing quantitative reporters such as DII-VENUS in conjunction with parameterized mathematical models to provide high-resolution kinetics of hormone redistribution.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
The F-box protein TIR1 is an auxin receptor
Dharmasiri, N., Dharmasiri, S., & Estelle, M. (2005) · Nature · doi:10.1038/nature03543 · Cited by 2,083
Self-citationMechanism of auxin perception by the TIR1 ubiquitin ligase
Tan, X., Calderon-Villalobos, L. I. A., Sharon, M., Zheng, C., Robinson, C. V., Estelle, M., & Zheng, N. (2007) · Nature · doi:10.1038/nature05731 · Cited by 1,688
Self-citationA novel sensor to map auxin response and distribution at high spatio-temporal resolution
Brunoud, G., Wells, D. M., Oliva, M., Larrieu, A., Mirabet, V., Burrow, A. H., Beeckman, T., Kepinski, S., Traas, J., Bennett, M. J., et al. (2012) · Nature · doi:10.1038/nature10791 · Cited by 741
Self-citation
Cited by
Leyser, O. (2018) · Plant Physiology · doi:10.1104/pp.17.00765 · Cited by 715
Metadata
- Authors
- Band, L. R., Wells, D. M., Larrieu, A., Sun, J., Middleton, A. M., French, A. P., Brunoud, G., Sato, E. M., Wilson, M. H., Péret, B., Oliva, M., Swarup, R., Sairanen, I., Parry, G., Ljung, K., Beeckman, T., Garibaldi, J. M., Estelle, M., Owen, M. R., Vissenberg, K., Hodgman, T. C., Pridmore, T. P., King, J. R., Vernoux, T., & Bennett, M. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-03-05
- Volume
- 109
- Issue
- 12
- Pages
- 4668-4673
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2152702131
- Cited by
- 345
- References
- 5
- FWCI
- 33.03
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Root gravitropism is regulated by a transient lateral auxin gradient controlled by a tipping-point mechanism. https://app.cochat.ai/papers/10.1073/pnas.1201498109
- The paper
- Band, L. R., Wells, D. M., Larrieu, A., Sun, J., Middleton, A. M., French, A. P., Brunoud, G., Sato, E. M., Wilson, M. H., Péret, B., Oliva, M., Swarup, R., Sairanen, I., Parry, G., Ljung, K., Beeckman, T., Garibaldi, J. M., Estelle, M., Owen, M. R., . . . Bennett, M. J. (2012). Root gravitropism is regulated by a transient lateral auxin gradient controlled by a tipping-point mechanism. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1201498109
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
