The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses
Open accessAbstract
Organisms have evolved endogenous biological clocks as internal timekeepers to coordinate metabolic processes with the external environment. Here, we seek to understand the mechanism of synchrony between the oscillator and products of metabolism known as Reactive Oxygen Species (ROS) in Arabidopsis thaliana . ROS-responsive genes exhibit a time-of-day–specific phase of expression under diurnal and circadian conditions, implying a role of the circadian clock in transcriptional regulation of these genes. Hydrogen peroxide production and scavenging also display time-of-day phases. Mutations in the core-clock regulator, CIRCADIAN CLOCK ASSOCIATED 1 ( CCA1 ), affect the transcriptional regulation of ROS-responsive genes, ROS homeostasis, and tolerance to oxidative stress. Mis-expression of EARLY FLOWERING 3 , LUX ARRHYTHMO , and TIMING OF CAB EXPRESSION 1 affect ROS production and transcription, indicating a global effect of the clock on the ROS network. We propose CCA1 as a master regulator of ROS homeostasis through association with the Evening Element in promoters of ROS genes in vivo to coordinate time-dependent responses to oxidative stress. We also find that ROS functions as an input signal that affects the transcriptional output of the clock, revealing an important link between ROS signaling and circadian output. Temporal coordination of ROS signaling by CCA1 and the reciprocal control of circadian output by ROS reveal a mechanistic link that allows plants to master oxidative stress responses.
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Cites
Reactive oxygen species: Metabolism, oxidative stress, and signal transduction
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Superoxide Dismutase and Stress Tolerance
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Reactive oxygen species produced by NADPH oxidase regulate plant cell growth
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Orchestrated Transcription of Key Pathways in Arabidopsis by the Circadian Clock
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Self-citationReciprocal Regulation Between TOC1 and LHY / CCA1 Within the Arabidopsis Circadian Clock
Alabadı́, D., Oyama, T., Yanovsky, M. J., Harmon, F. G., Más, P., & Kay, S. A. (2001) · Science · doi:10.1126/science.1061320 · Cited by 1,161
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Wheels within wheels: the plant circadian system
Hsu, P. Y., & Harmer, S. L. (2014) · Trends in Plant Science · doi:10.1016/j.tplants.2013.11.007 · Cited by 379
Pekovic-Vaughan, V., Gibbs, J., Yoshitane, H., Yang, N., Pathiranage, D., Guo, B., Sagami, A., Taguchi, K., Bechtold, D., Loudon, A., et al. (2014) · Genes & Development · doi:10.1101/gad.237081.113 · Cited by 323
Orchestrating rapid long‐distance signaling in plants with Ca2+, ROS and electrical signals
Choi, W., Miller, G., Wallace, I., Harper, J., Mittler, R., & Gilroy, S. (2017) · The Plant Journal · doi:10.1111/tpj.13492 · Cited by 312
Magnetic field effects in biology from the perspective of the radical pair mechanism
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Metadata
- Authors
- Lai, A. G., Doherty, C. J., Mueller-Roeber, B., Kay, S. A., Schippers, J. H. M., & Dijkwel, P. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-10
- Volume
- 109
- Issue
- 42
- Pages
- 17129-17134
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2162840029
- Cited by
- 371
- References
- 49
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Lai, A. G., Doherty, C. J., Mueller-Roeber, B., Kay, S. A., Schippers, J. H. M., & Dijkwel, P. P. (2012). CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1209148109
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