The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Brassinosteroids regulate organ boundary formation in the shoot apical meristem of Arabidopsis
Open accessAbstract
Spatiotemporal control of the formation of organ primordia and organ boundaries from the stem cell niche in the shoot apical meristem (SAM) determines the patterning and architecture of plants, but the underlying signaling mechanisms remain poorly understood. Here we show that brassinosteroids (BRs) play a key role in organ boundary formation by repressing organ boundary identity genes. BR-hypersensitive mutants display organ-fusion phenotypes, whereas BR-insensitive mutants show enhanced organ boundaries. The BR-activated transcription factor BZR1 directly represses the CUP-SHAPED COTYLEDON ( CUC ) family of organ boundary identity genes. In WT plants, BZR1 accumulates at high levels in the nuclei of central meristem and organ primordia but at a low level in organ boundary cells to allow CUC gene expression. Activation of BR signaling represses CUC gene expression and causes organ fusion phenotypes. This study uncovers a role for BR in the spatiotemporal control of organ boundary formation and morphogenesis in the SAM.
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“The LOB1-mediated decrease of brassinosteroid activity causes a reduction of cell size and cell division rate in the boundary zone compared to neighboring zones (Bell et al., 2012; Gendron et al., 2012).”
From Shaping plant architecture (2015) · cites this paper as Gendron et al., 2012
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“In addition, LOF1 and CUC genes show complex interactions, regulating each other's expression (Lee et al., 2009;Gendron et al., 2012; Fig. 3).”
From Divide et impera: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Gendron et al., 2012
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“CUC genes are down-regulated by brassinosteroids.”
From Shaping plant architecture (2015) · cites this paper as Gendron et al., 2012
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“Thus, low brassinosteroid activity in the boundary zone not only reduces cell expansion and division as described above, but also allows the induction of CUC genes (Bell et al., 2012; Gendron et al., 2012).”
From Shaping plant architecture (2015) · cites this paper as Gendron et al., 2012
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“In wild type, BZR1 proteins accumulate to high levels in the central meristem and organ primordia, limiting the expression of a specific set of genes, including CUC genes, to the boundary (Gendron et al., 2012).”
From Divide et impera: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Gendron et al., 2012
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Cites
Genes involved in organ separation in Arabidopsis: an analysis of the cup-shaped cotyledon mutant.
Aida, M., Ishida, T., Fukaki, H., Fujisawa, H., & Tasaka, M. (1997) · The Plant Cell · doi:10.1105/tpc.9.6.841 · Cited by 1,486
BRASSINOSTEROIDS: Essential Regulators of Plant Growth and Development
Clouse, S. D., & Sasse, J. M. (1998) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.49.1.427 · Cited by 1,462
Heisler, M. G., Ohno, C., Das, P., Sieber, P., Reddy, G. V., Long, J. A., & Meyerowitz, E. M. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.052 · Cited by 1,189
Wang, Z., Nakano, T., Gendron, J. M., He, J., Chen, M., Vafeados, D. K., Yang, Y., Fujioka, S., Yoshida, S., Asami, T., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00153-3 · Cited by 1,148
Self-citationSun, Y., Fan, X.-Y., Cao, D.-M., Tang, W., He, K., Zhu, J.-Y., He, J.-X., Bai, M., Zhu, S., Oh, E., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.10.010 · Cited by 1,002
Self-citationSzekeres, M., Németh, K., Koncz–Kálmán, Z., Mathur, J., Kauschmann, A., Altmann, T., Rédei, G. P., Nagy, F., Schell, J., & Koncz, C. (1996) · Cell · doi:10.1016/s0092-8674(00)81094-6 · Cited by 998
Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses
Oh, E., Zhu, J.-Y., & Wang, Z. (2012) · Nature Cell Biology · doi:10.1038/ncb2545 · Cited by 886
Self-citationHe, J., Gendron, J. M., Sun, Y., Gampala, S. S. L., Gendron, N., Sun, C. Q., & Wang, Z. (2005) · Science · doi:10.1126/science.1107580 · Cited by 868
Self-citationA Role for Brassinosteroids in Light-Dependent Development of Arabidopsis
Li, J., Nagpal, P., Vitart, V., McMorris, T. C., & Chory, J. (1996) · Science · doi:10.1126/science.272.5260.398 · Cited by 856
Yamamuro, C., Ihara, Y., Wu, X., Noguchi, T., Fujioka, S., Takatsuto, S., Ashikari, M., Kitano, H., & Matsuoka, M. (2000) · The Plant Cell · doi:10.1105/tpc.12.9.1591 · Cited by 758
Cited by
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Items 201–205 of 205
Wang, R., Wu, T., Jiang, W., Du, X., Mo, W., Li, Z. Y., Chen, M., Zhang, H., Zheng, H., Qiusheng, E., et al. (2026) · Plant Cell & Environment · doi:10.1111/pce.70705
Hormonal architects: Plant steroids shape meristems
Barragán-Lozano, T., Song, W., Ma, Q., Lozano, R., & Russinova, E. (2026) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2026.102961
Transcription factors in the regulation of shoot development and branching
Sameena, S., Reddy, K. S., Rajakumar, S. A., Kumar, A., Mounika, T., Reddy, P. C. O., & Sekhar, A. C. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33748-2.00003-3
Khalid, I., Nida, Qureshi, M. I., Abdin, M. Z., & Ahmad, J. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33748-2.00019-7
Vilarrasa‐Blasi, J. (2014) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Metadata
- Authors
- Gendron, J. M., Liu, J.-S., Fan, M., Bai, M.-Y., Wenkel, S., Springer, P. S., Barton, M. K., & Wang, Z.-Y.
- Affiliations
- Carnegie Institution for Science (US)
- Department of Plant Biology, Carnegie Institution for Science, Stanford, CA 94305; and
- University of California, Riverside (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-12-04
- Volume
- 109
- Issue
- 51
- Pages
- 21152-21157
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3529081
- OpenAlex
- W2141148584
- Cited by
- 205
- References
- 48
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 14 · 2023: 8 · 2022: 11 · 2021: 15 · 2020: 15 · 2019: 14 · 2018: 11 · 2017: 19 · 2016: 10 · 2015: 26 · 2014: 12 · 2013: 17 · 2012: 2
- FWCI
- 20.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM066258)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant tissue culture and regeneration
- Keywords
- brassinosteroids, shoot apical meristem, BZR1, organ primordia, transcriptional repression, plant morphogenesis
- MeSH terms
- Cell Nucleus, Microscopy, Electron, Scanning, Mutation, Phenotype, Signal Transduction, Genes, Plant, Arabidopsis, Gene Expression Regulation, Plant, Meristem, Plant Shoots, Microscopy, Confocal, Arabidopsis Proteins, Chromatin Immunoprecipitation, Brassinosteroids
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