The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Inhibition of tumor growth and metastasis by a self-therapeutic nanoparticle
Open accessAbstract
Although biomedical applications of nanotechnology, which typically involve functionalized nanoparticles, have taken significant strides, biological characterization of unmodified nanoparticles remains underinvestigated. Herein we demonstrate that unmodified gold nanoparticles (AuNPs) inhibit the proliferation of cancer cells in a size- and concentration-dependent manner by abrogating MAPK-signaling. In addition, these AuNPs reverse epithelial-mesenchymal transition (EMT) in cancer cells by reducing secretion of a number of proteins involved in EMT, up-regulating E-Cadherin, and down-regulating Snail, N-Cadherin, and Vimentin. Inhibition of MAPK signaling and reversal of EMT upon AuNP treatment inhibits tumor growth and metastasis in two separate orthotopic models of ovarian cancer. Western blot analyses of tumor tissues reveal up-regulation of E-Cadherin and down-regulation of Snail and phospho-MAPK, confirming the reversal of EMT and inhibition of MAPK signaling upon AuNP treatment. The ability of a single self-therapeutic nanoparticle to abrogate signaling cascades of multiple growth factors is distinctive and purports possible medical applications as potential antitumor and antimetastatic agent.
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Cites
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“Since HB–GFs are critically important for angiogenesis and epithelial–mesenchymal transition (EMT), a mechanism that confers metastatic potential to tumor cells, AuNPs may find wide applications as therapeutic agents in angiogenesisdependent disorders and in preventing tumor growth and metastasis in cancer (4).”
BackgroundMassagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907
Early Events in the Pathogenesis of Epithelial Ovarian Cancer
Landen, C. N., Birrer, M. J., & Sood, A. K. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.9970 · Cited by 462
Cited by
Gold Nanoparticles in Cancer Treatment
Sztandera, K., Gorzkiewicz, M., & Klajnert-Maculewicz, B. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00810 · Cited by 607
Jo, D. H., Kim, J. H., Lee, T. G., & Kim, J. H. (2015) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2015.04.015 · Cited by 433
Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials
Chen, W., Luo, G., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201802725 · Cited by 373
Gold-Nanoparticle-Assisted Plasmonic Photothermal Therapy Advances Toward Clinical Application
Ali, M. R. K., Wu, Y., & El-Sayed, M. A. (2019) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.9b01961 · Cited by 346
Yang, L., Moss, T., Mangala, L. S., Marini, J., Zhao, H., Wahlig, S., Armaiz‐Pena, G., Jiang, D., Achreja, A., Win, J., et al. (2014) · Molecular Systems Biology · doi:10.1002/msb.20134892 · Cited by 326
Metadata
- Authors
- Arvizo, R. R., Saha, S., Wang, E., Robertson, J. D., Bhattacharya, R., & Mukherjee, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-04-08
- Volume
- 110
- Issue
- 17
- Pages
- 6700-6705
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2097103399
- Cited by
- 237
- References
- 5
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Arvizo, R. R., Saha, S., Wang, E., Robertson, J. D., Bhattacharya, R., & Mukherjee, P. (2013). Inhibition of tumor growth and metastasis by a self-therapeutic nanoparticle. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1214547110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
