The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Cardiomyocyte proliferation contributes to heart growth in young humans
Open accessAbstract
The human heart is believed to grow by enlargement but not proliferation of cardiomyocytes (heart muscle cells) during postnatal development. However, recent studies have shown that cardiomyocyte proliferation is a mechanism of cardiac growth and regeneration in animals. Combined with evidence for cardiomyocyte turnover in adult humans, this suggests that cardiomyocyte proliferation may play an unrecognized role during the period of developmental heart growth between birth and adolescence. We tested this hypothesis by examining the cellular growth mechanisms of the left ventricle on a set of healthy hearts from humans aged 0–59 y ( n = 36). The percentages of cardiomyocytes in mitosis and cytokinesis were highest in infants, decreasing to low levels by 20 y. Although cardiomyocyte mitosis was detectable throughout life, cardiomyocyte cytokinesis was not evident after 20 y. Between the first year and 20 y of life, the number of cardiomyocytes in the left ventricle increased 3.4-fold, which was consistent with our predictions based on measured cardiomyocyte cell cycle activity. Our findings show that cardiomyocyte proliferation contributes to developmental heart growth in young humans. This suggests that children and adolescents may be able to regenerate myocardium, that abnormal cardiomyocyte proliferation may be involved in myocardial diseases that affect this population, and that these diseases might be treatable through stimulation of cardiomyocyte proliferation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
4 retracted
Bolli, R., Chugh, A. R., D'Amario, D., Loughran, J. H., Stoddard, M. F., Ikram, S., Beache, G. M., Wagner, S. G., Leri, A., Hosoda, T., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61590-0 · Cited by 1,288
RetractedCardiomyogenesis in the Adult Human Heart
Kajstura, J., Urbanek, K., Perl, S., Hosoda, T., Zheng, H., Ogórek, B., Ferreira-Martins, J., Goichberg, P., Rondon-Clavo, C., Sanada, F., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.223024 · Cited by 310
RetractedCardiomyogenesis in the Aging and Failing Human Heart
Kajstura, J., Rota, M., Cappetta, D., Ogórek, B., Arranto, C., Bai, Y., Ferreira‐Martins, J., Signore, S., Sanada, F., Matsuda, A., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.118380 · Cited by 128
RetractedCardiomyogenesis in the Developing Heart Is Regulated by C-Kit–Positive Cardiac Stem Cells
Ferreira‐Martins, J., Ogórek, B., Cappetta, D., Matsuda, A., Signore, S., D’Amario, D., Kostyla, J., Steadman, E., Ide-Iwata, N., Sanada, F., et al. (2012) · Circulation Research · doi:10.1161/circresaha.111.259507 · Cited by 110
RetractedHeart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333
Locally Weighted Regression: An Approach to Regression Analysis by Local Fitting
Cleveland, W. S., & Devlin, S. J. (1988) · Journal of the American Statistical Association · doi:10.1080/01621459.1988.10478639 · Cited by 5,742
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130
Self-citationTransient Regenerative Potential of the Neonatal Mouse Heart
Porrello, E. R., Mahmoud, A. I., Simpson, E., Hill, J. A., Richardson, J. A., Olson, E. N., & Sadek, H. A. (2011) · Science · doi:10.1126/science.1200708 · Cited by 2,545
Heart Regeneration in Zebrafish
Poss, K. D., Wilson, L. G., & Keating, M. T. (2002) · Science · doi:10.1126/science.1077857 · Cited by 1,932
Haycock, G. B., Schwartz, G. J., & Wisotsky, D. H. (1978) · The Journal of Pediatrics · doi:10.1016/s0022-3476(78)80601-5 · Cited by 1,675
Cited by
Revisiting Cardiac Cellular Composition
Pinto, A. R., Ilinykh, A., Ivey, M. J., Kuwabara, J. T., D’Antoni, M. L., Debuque, R., Chandran, A., Wang, L., Arora, K., Rosenthal, N. A., et al. (2016) · Circulation Research · doi:10.1161/circresaha.115.307778 · Cited by 1,400
“This is because of the variability and dynamism of the number of nuclei per cardiomyocyte in addition to the differences between rodents and humans—most murine cardiomyocytes are binucleated,(32,33) whereas most human cardiomyocytes are mononucleated.(2,34) Therefore, estimations of myocyte to nonmyocyte ratios will d…”
BackgroundCardiomyocyte Maturation: New Phase in Development
Guo, Y., & Pu, W. T. (2020) · Circulation Research · doi:10.1161/circresaha.119.315862 · Cited by 653
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence
Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, J., Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100492 · Cited by 532
“In the mdx 4cv / mTR G2 mouse model of telomere dysfunction, reduced expression of shelterin components is suggested to underlie increased telomere erosion in CMs (Mourkioti et al , 2013; Chang et al , 2016).”
The N 6 -Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy
Dorn, L. E., Lasman, L., Chen, J., Xu, X., Hund, T. J., Medvedovic, M., Hanna, J. H., van Berlo, J. H., & Accornero, F. (2019) · Circulation · doi:10.1161/circulationaha.118.036146 · Cited by 466
Hippo signaling impedes adult heart regeneration
Heallen, T., Morikawa, Y., Leach, J., Tao, G., Willerson, J. T., Johnson, R. L., & Martin, J. F. (2013) · Development · doi:10.1242/dev.102798 · Cited by 458
Metadata
- Authors
- Mollova, M., Bersell, K., Walsh, S., Savla, J., Das, L. T., Park, S.-Y., Silberstein, L. E., dos Remedios, C. G., Graham, D., Colan, S., & Kühn, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-01-09
- Volume
- 110
- Issue
- 4
- Pages
- 1446-1451
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2059062907
- Cited by
- 733
- References
- 39
- FWCI
- 24.34
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cardiomyocyte proliferation contributes to heart growth in young humans. https://app.cochat.ai/papers/10.1073/pnas.1214608110
- The paper
- Mollova, M., Bersell, K., Walsh, S., Savla, J., Das, L. T., Park, S.-Y., Silberstein, L. E., dos Remedios, C. G., Graham, D., Colan, S., & Kühn, B. (2013). Cardiomyocyte proliferation contributes to heart growth in young humans. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1214608110
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
