The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells
Open accessAbstract
The biological significance of a known normal and cancer stem cell marker CD133 remains elusive. We now demonstrate that the phosphorylation of tyrosine-828 residue in CD133 C-terminal cytoplasmic domain mediates direct interaction between CD133 and phosphoinositide 3-kinase (PI3K) 85 kDa regulatory subunit (p85), resulting in preferential activation of PI3K/protein kinase B (Akt) pathway in glioma stem cell (GSC) relative to matched nonstem cell. CD133 knockdown potently inhibits the activity of PI3K/Akt pathway with an accompanying reduction in the self-renewal and tumorigenicity of GSC. The inhibitory effects of CD133 knockdown could be completely rescued by expression of WT CD133, but not its p85-binding deficient Y828F mutant. Analysis of glioma samples reveals that CD133 Y828 phosphorylation level is correlated with histopathological grade and overlaps with Akt activation. Our results identify the CD133/PI3K/Akt signaling axis, exploring the fundamental role of CD133 in glioma stem cell behavior.
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Cites
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network (2008) · Nature · doi:10.1038/nature07385 · Cited by 7,735
AKT/PKB signaling: navigating downstream
Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857
Self-citationYeatman, T. J. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1366 · Cited by 1,113
Yamazaki, S., Iwama, A., Takayanagi, S., Morita, Y., Eto, K., Ema, H., & Nakauchi, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601236 · Cited by 270
Cited by
Cancer stem cells in glioblastoma
Lathia, J. D., Mack, S. C., Mulkearns-Hubert, E. E., Valentim, C. L. L., & Rich, J. N. (2015) · Genes & Development · doi:10.1101/gad.261982.115 · Cited by 1,520
A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms
Cojoc, M., Mäbert, K., Muders, M. H., & Dubrovska, A. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.06.004 · Cited by 393
Shi, Y., Ping, Y.-F., Zhou, W., He, Z.-C., Chen, C., Bian, B.-S.-J., Zhang, L., Chen, L., Lan, X., Zhang, X.-C., et al. (2017) · Nature Communications · doi:10.1038/ncomms15080 · Cited by 344
Self-citationCD133: a stem cell biomarker and beyond
Li, Z. (2013) · Experimental Hematology & Oncology · doi:10.1186/2162-3619-2-17 · Cited by 331
The role of microRNAs in the regulation of cancer stem cells
Takahashi, R.-U., Miyazaki, H., & Ochiya, T. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2013.00295 · Cited by 118
Metadata
- Authors
- Wei, Y., Jiang, Y., Zou, F., Liu, Y., Wang, S., Xu, N., Xu, W., Cui, C., Xing, Y., Liu, Y., Cao, B., Liu, C., Wu, G., Ao, H., Zhang, X., & Jiang, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-04-08
- Volume
- 110
- Issue
- 17
- Pages
- 6829-6834
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2117735955
- Cited by
- 274
- References
- 5
- FWCI
- 11.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wei, Y., Jiang, Y., Zou, F., Liu, Y., Wang, S., Xu, N., Xu, W., Cui, C., Xing, Y., Liu, Y., Cao, B., Liu, C., Wu, G., Ao, H., Zhang, X., & Jiang, J. (2013). Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1217002110
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