Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells
Open accessAbstract
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) niche in a noncycling state and enter the cell cycle at long intervals. However, little is known about inter- and intracellular signaling mechanisms underlying this unique property of HSCs. Here, we show that lipid raft clustering is a key event in the regulation of HSC dormancy. Freshly isolated HSCs from the BM niche lack lipid raft clustering, exhibit repression of the AKT-FOXO signaling pathway, and express abundant p57(Kip2) cyclin-dependent kinase inhibitor. Lipid raft clustering induced by cytokines is essential for HSC re-entry into the cell cycle. Conversely, inhibition of lipid raft clustering caused sustained nuclear accumulation of FOXO transcription factors and induced HSC hibernation ex vivo. These data establish a critical role for lipid rafts in regulating the cell cycle, the survival, and the entry into apoptosis of HSCs and uncover a striking similarity in HSC hibernation and Caenorhabditis elegans dauer formation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Low levels of p57 have been associated with stem cell hibernation.
“low levels of p57 have been associated with stem cell hibernation (Yamazaki et al., 2006)”
From Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells (2017) · cites this paper as Yamazaki et al., 2006
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Osteoblastic cells regulate the haematopoietic stem cell niche
Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Pajevic, P. D., Bringhurst, F. R., et al. (2003) · Nature · doi:10.1038/nature02040 · Cited by 3,452 · see citing works
Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168 · see citing works
Identification of the haematopoietic stem cell niche and control of the niche size
Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948 · see citing works
Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell
Osawa, M., Hanada, K., Hamada, H., & Nakauchi, H. (1996) · Science · doi:10.1126/science.273.5272.242 · Cited by 2,141 · see citing works
Self-citationTie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G. Y., & Suda, T. (2004) · Cell · doi:10.1016/j.cell.2004.07.004 · Cited by 1,958 · see citing works
Heissig, B., Hattori, K., Dias, S., Friedrich, M., Ferris, B., Hackett, N. R., Crystal, R. G., Besmer, P., Lyden, D. C., Moore, M. A. S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00754-7 · Cited by 1,744 · see citing works
Socializing with the Neighbors
Fuchs, E. V., Tumbar, T., & Guasch, G. (2004) · Cell · doi:10.1016/s0092-8674(04)00255-7 · Cited by 1,711 · see citing works
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
Kops, G. J. P. L., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W. A., Coffer, P. J., Huang, T.-T., Bos, J. L., Medema, R. H., & Burgering, B. M. T. (2002) · Nature · doi:10.1038/nature01036 · Cited by 1,580 · see citing works
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
Medema, R. H., Kops, G. J. P. L., Bos, J. L., & Burgering, B. M. T. (2000) · Nature · doi:10.1038/35008115 · Cited by 1,439 · see citing works
Hematopoietic Stem Cell Quiescence Maintained by p21 <sup>cip1/waf1</sup>
Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339 · see citing works
Seoane, J., Le, H.-V., Shen, L., Anderson, S. A., & Massagué, J. (2004) · Cell · doi:10.1016/s0092-8674(04)00298-3 · Cited by 1,029 · see citing works
Cheshier, S. H., Morrison, S. J., Liao, X., & Weissman, I. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3120 · Cited by 858 · see citing works
Association of Spindle Assembly Checkpoint Component XMAD2 with Unattached Kinetochores
Chen, R., Waters, J. C., Salmon, E. D., & Murray, A. W. (1996) · Science · doi:10.1126/science.274.5285.242 · Cited by 783 · see citing works
Age-Associated Characteristics of Murine Hematopoietic Stem Cells
Sudo, K., Ema, H., Morita, Y., & Nakauchi, H. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1273 · Cited by 722 · see citing works
Self-citationBlood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche
Taichman, R. S. (2004) · Blood · doi:10.1182/blood-2004-06-2480 · Cited by 648 · see citing works
Mouse development and cell proliferation in the absence of D-cyclins
Kozar, K., Ciemerych, M. A., Rebel, V. I., Shigematsu, H., Zagozdzon, A., Sicinska, E., Geng, Y., Yu, Q., Bhattacharya, S., Bronson, R. T., et al. (2004) · Cell · doi:10.1016/j.cell.2004.07.025 · Cited by 647 · see citing works
Cell cycle and death control: long live Forkheads
Burgering, B. M. T., & Kops, G. J. P. L. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02113-8 · Cited by 642 · see citing works
cell cycle and death control: long live Forkheads
Burgering, B. M. T., Medema, R. H., & Kops, G. J. P. L. (2002) · GBM Annual Fall meeting Halle 2002 · doi:10.1240/sav_gbm_2002_h_000075 · Cited by 586 · see citing works
Bhatia, R., Holtz, M. S., Niu, N., Gray, R., Snyder, D., Sawyers, C. L., Arber, D. A., Slovak, M. L., & Forman, S. J. (2003) · Blood · doi:10.1182/blood-2002-09-2780 · Cited by 543 · see citing works
Stem cell repopulation efficiency but not pool size is governed by p27kip1
Cheng, T., Rodrigues, N. P., Dombkowski, D., Stier, S., & Scadden, D. T. (2000) · Nature Medicine · doi:10.1038/81335 · Cited by 347 · see citing works
Transforming growth factor-β: pleiotropic role in the regulation of hematopoiesis
Fortunel, N. O., Hatzfeld, A., & Hatzfeld, J. (2000) · Blood · doi:10.1182/blood.v96.6.2022.h8002022_2022_2036 · Cited by 314 · see citing works
In Vitro Self-Renewal Division of Hematopoietic Stem Cells
Ema, H., Takano, H., Sudo, K., & Nakauchi, H. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1281 · Cited by 284 · see citing works
Self-citationAsymmetric Division and Lineage Commitment at the Level of Hematopoietic Stem Cells
Takano, H., Ema, H., Sudo, K., & Nakauchi, H. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20030929 · Cited by 208 · see citing works
Self-citationEma, H., Sudo, K., Seita, J., Matsubara, A., Morita, Y., Osawa, M., Takatsu, K., Τακακι, S., & Nakauchi, H. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.019 · Cited by 197 · see citing works
Self-citationCritical Role of Cyclin D1 Nuclear Import in Cardiomyocyte Proliferation
Tamamori‐Adachi, M., Ito, H., Sumrejkanchanakij, P., Adachi, S., Hiroe, M., Shimizu, M., Kawauchi, J., Sunamori, M., Marumo, F., Kitajima, S., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000049105.15329.1c · Cited by 150 · see citing works
Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis
Osawa, M. (2002) · Blood · doi:10.1182/blood-2002-01-0182 · Cited by 130 · see citing works
Komatsu, N., Watanabe, T., Uchida, M., Mori, M., Kirito, K., Kikuchi, S., Liu, Q., Tauchi, T., Miyazawa, K., Endo, H., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211562200 · Cited by 117 · see citing works
Miceli, M. C., Moran, M., Chung, C. D., Patel, V. P., Low, T. A., & Zinnanti, W. J. (2001) · Seminars in Immunology · doi:10.1006/smim.2000.0303 · Cited by 103 · see citing works
Tajima, Y., Moore, M. A. S., Soares, V. C., Ono, M., Kissel, H., & Besmer, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11903 · Cited by 88 · see citing works
Cheng, T., Shen, H., Rodrigues, N. P., Stier, S., & Scadden, D. T. (2001) · Blood · doi:10.1182/blood.v98.13.3643 · Cited by 79 · see citing works
Cai, D., McCarron, R. M., Yu, E. Z., Li, Y., & Hallenbeck, J. M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.04.008 · Cited by 70 · see citing works
Jaumot, M., Estanyol, J. M., Serratosa, J., Agell, N., & Bachs, O. (1999) · Hepatology · doi:10.1002/hep.510290226 · Cited by 60 · see citing works
Cai, D., McCarron, R. M., & Hallenbeck, J. M. (2004) · Gene · doi:10.1016/j.gene.2004.09.003 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Programmed Cell Death in Animal Development and Disease
Fuchs, Y., & Steller, H. (2011) · Cell · doi:10.1016/j.cell.2011.10.033 · Cited by 1,915 · see citing works
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature · doi:10.1038/nature05862 · Cited by 1,115 · see citing works
Metabolic requirements for the maintenance of self-renewing stem cells
Ito, K., & Suda, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3772 · Cited by 1,014 · see citing works
Foxo3a is essential for maintenance of the hematopoietic stem cell pool
Miyamoto, K., Kazuhito, N., & Atsushi, H. (2009) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 858 · see citing works
Omatsu, Y., Sugiyama, T., Kohara, H., Kondoh, G., Fujii, N., Kohno, K., & Nagasawa, T. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.017 · Cited by 849 · see citing works
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
Suda, T., Takubo, K., & Semenza, G. L. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.09.010 · Cited by 844 · see citing works
Yoshihara, H., Arai, F., Hosokawa, K., Hagiwara, T., Takubo, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Matsuoka, S., Miyamoto, K., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.10.020 · Cited by 816 · see citing works
Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
Yamazaki, S., Ema, H., Karlsson, G., Yamaguchi, T., Miyoshi, H., Shioda, S., Taketo, M. M., Karlsson, S., Iwama, A., & Nakauchi, H. (2011) · Cell · doi:10.1016/j.cell.2011.09.053 · Cited by 797 · see citing works
Self-citationAnalysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells
Foudi, A., Hochedlinger, K., Van Buren, D., Schindler, J. W., Jaenisch, R., Carey, V., & Hock, H. (2009) · Nature Biotechnology · doi:10.1038/nbt.1517 · Cited by 586 · see citing works
TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
Naka, K., Hoshii, T., Muraguchi, T., Tadokoro, Y., Ooshio, T., Kondo, Y., Nakao, S., Motoyama, N., & Hirao, A. (2010) · Nature · doi:10.1038/nature08734 · Cited by 583 · see citing works
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
Qian, H., Buza-Vidas, N., Hyland, C. D., Jensen, C. T., Antonchuk, J., Månsson, R., Thorén, L., Ekblom, M., Alexander, W. S., & Jacobsen, S. E. W. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.10.008 · Cited by 563 · see citing works
Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment
Morita, Y., Ema, H., & Nakauchi, H. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091318 · Cited by 456 · see citing works
Self-citationCell cycle regulation in hematopoietic stem cells
Pietras, E. M., Warr, M. R., & Passegué, E. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102131 · Cited by 447 · see citing works
Oxidative Stress in the Regulation of Normal and Neoplastic Hematopoiesis
Ghaffari, S. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2142 · Cited by 377 · see citing works
Dynamic niches in the origination and differentiation of haematopoietic stem cells
Wang, L. D., & Wagers, A. J. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3184 · Cited by 343 · see citing works
FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System
Tothova, Z., & Gilliland, D. G. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.07.017 · Cited by 331 · see citing works
p57 is required for quiescence and maintenance of adult hematopoietic stem cells
Matsumoto, A., Takeishi, S., Kanie, T., Susaki, E., Onoyama, I., Tateishi, Y., Nakayama, K., & Nakayama, K. I. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.06.014 · Cited by 329 · see citing works
TGF-β as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation
Yamazaki, S., Iwama, A., Takayanagi, S., Eto, K., Ema, H., & Nakauchi, H. (2008) · Blood · doi:10.1182/blood-2008-04-146480 · Cited by 327 · see citing works
Self-citationPietras, E. M., Lakshminarasimhan, R., Techner, J.-M., Fong, S., Flach, J., Binnewies, M., & Passegué, E. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20131043 · Cited by 323 · see citing works
Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells
Nalapareddy, K., Nattamai, K. J., Kumar, R. S., Karns, R., Wikenheiser-Brokamp, K. A., Sampson, L. L., Mahe, M. M., Sundaram, N., Yacyshyn, M.-B., Yacyshyn, B., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.056 · Cited by 280 · see citing works
Zou, P., Yoshihara, H., Hosokawa, K., Tai, I., Shinmyozu, K., Tsukahara, F., Maru, Y., Nakayama, K., Nakayama, K. I., & Suda, T. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.07.003 · Cited by 289 · see citing works
Regulation of reactive oxygen species in stem cells and cancer stem cells
Kobayashi, C. I., & Suda, T. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22764 · Cited by 290 · see citing works
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species
Juntilla, M. M., Patil, V. D., Calamito, M., Joshi, R. P., Birnbaum, M. J., & Koretzky, G. A. (2010) · Blood · doi:10.1182/blood-2009-09-241000 · Cited by 284 · see citing works
TGF-β signaling in the control of hematopoietic stem cells
Blank, U., & Karlsson, S. (2015) · Blood · doi:10.1182/blood-2014-12-618090 · Cited by 277 · see citing works
Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
Vannini, N., Girotra, M., Naveiras, O., Nikitin, G. F., Campos, V., Giger, S., Roch, A., Auwerx, J. H., & Lütolf, M. P. (2016) · Nature Communications · doi:10.1038/ncomms13125 · Cited by 272 · see citing works
Wei, Y., Jiang, Y., Zou, F., Liu, Y., Wang, S., Xu, N., Xu, W., Cui, C., Xing, Y., Liu, Y., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217002110 · Cited by 271 · see citing works
Cellular barcoding tool for clonal analysis in the hematopoietic system
Gerrits, A., Dykstra, B. J., Kalmykowa, O. J., Klauke, K., Verovskaya, E. V., Broekhuis, M., de Haan, G., & Bystrykh, L. V. (2010) · Blood · doi:10.1182/blood-2009-06-229757 · Cited by 253 · see citing works
Regulation of Reactive Oxygen Species and Genomic Stability in Hematopoietic Stem Cells
Naka, K., Muraguchi, T., Hoshii, T., & Hirao, A. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2114 · Cited by 244 · see citing works
Pbx1 Regulates Self-Renewal of Long-Term Hematopoietic Stem Cells by Maintaining Their Quiescence
Ficara, F., Murphy, M., Lin, M., & Cleary, M. L. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.03.004 · Cited by 235 · see citing works
Cytoskeleton–membrane interactions in membrane raft structure
Chichili, G. R., & Rodgers, W. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0022-6 · Cited by 235 · see citing works
Valcourt, J. R., Lemons, J. M. S., Haley, E. M., Kojima, M. L., Demuren, O. O., & Coller, H. A. (2012) · Cell Cycle · doi:10.4161/cc.19879 · Cited by 229 · see citing works
Framework models of tumor dormancy from patient-derived observations
Klein, C. A. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.011 · Cited by 207 · see citing works
Mimicking stem cell niches to increase stem cell expansion
Dellatore, S. M., Garcia, A. S., & Miller, W. M. (2008) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2008.07.010 · Cited by 207 · see citing works
C/EBPδ regulates cell cycle and self-renewal of human limbal stem cells
Barbaro, V., Testa, A., Iorio, E. D., Mavilio, F., Pellegrini, G., & Luca, M. D. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703003 · Cited by 202 · see citing works
The Harmonies Played by TGF-β in Stem Cell Biology
Oshimori, N., & Fuchs, E. V. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.11.001 · Cited by 189 · see citing works
Targeting leukemic stem cells by breaking their dormancy
Essers, M., & Trumpp, A. (2010) · Molecular Oncology · doi:10.1016/j.molonc.2010.06.001 · Cited by 190 · see citing works
Adult mouse hematopoietic stem cells: purification and single-cell assays
Ema, H., Morita, Y., Yamazaki, S., Matsubara, A., Seita, J., Tadokoro, Y., Kondo, H., Takano, H., & Nakauchi, H. (2006) · Nature Protocols · doi:10.1038/nprot.2006.447 · Cited by 184 · see citing works
Self-citationYoshida, T., Hazan, I., Zhang, J., Ng, S. Y., Naito, T., Snippert, H. J. G., Heller, E. J., Qi, X., Lawton, L. N., Williams, C. J., et al. (2008) · Genes & Development · doi:10.1101/gad.1642808 · Cited by 180 · see citing works
Activin/nodal signalling in stem cells
Pauklin, S., & Vallier, L. (2015) · Development · doi:10.1242/dev.091769 · Cited by 183 · see citing works
Eliasson, P., Rehn, M., Hammar, P., Larsson, P., Sirenko, O., Flippin, L. A., Cammenga, J., & Jönsson, J. (2010) · Experimental Hematology · doi:10.1016/j.exphem.2010.01.005 · Cited by 177 · see citing works
Oxidative Stress Regulation of Stem and Progenitor Cells
Pervaiz, S., Taneja, R., & Ghaffari, S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2804 · Cited by 176 · see citing works
Chemically defined cytokine-free expansion of human haematopoietic stem cells
Sakurai, M., Ishitsuka, K., Ito, R., Wilkinson, A. C., Kimura, T., Mizutani, E., Nishikii, H., Sudo, K., Becker, H., Takemoto, H., et al. (2023) · Nature · doi:10.1038/s41586-023-05739-9 · Cited by 164 · see citing works
Self-citationThe Role of Glycosphingolipids in Immune Cell Functions
Zhang, T., de Waard, A. A., Wuhrer, M., & Spaapen, R. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00090 · Cited by 153 · see citing works
p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis
Furutachi, S., Matsumoto, A., Nakayama, K. I., & Gotoh, Y. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.50 · Cited by 154 · see citing works
Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells
Nagasawa, T., Omatsu, Y., & Sugiyama, T. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.03.009 · Cited by 149 · see citing works
Seita, J., Ema, H., Ooehara, J., Yamazaki, S., Tadokoro, Y., Yamasaki, A., Eto, K., Τακακι, S., Takatsu, K., & Nakauchi, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606238104 · Cited by 147 · see citing works
Self-citationTGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and DifferentiationPreprint
Mullen, A. C., & Wrana, J. L. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022186 · Cited by 147 · see citing works
Comparison of bone marrow and adipose tissue-derived canine mesenchymal stem cells
Takemitsu, H., Zhao, D., YAMAMOTO, I., Harada, Y., Michishita, M., & Arai, T. (2012) · BMC Veterinary Research · doi:10.1186/1746-6148-8-150 · Cited by 144 · see citing works
Yalcin, S., Marinković, D., Mungamuri, S. K., Zhang, X., Tong, W., Sellers, R. S., & Ghaffari, S. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.292 · Cited by 144 · see citing works
Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling
Arcaro, A., Aubert, M., del Hierro, M. E. E., Khanzada, U. K., Angelidou, S., Tetley, T. D., Bittermann, A. G., Frame, M. C., & Seckl, M. J. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.12.003 · Cited by 138 · see citing works
Metabolism and the Control of Cell Fate Decisions and Stem Cell Renewal
Ito, K., & Ito, K. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125134 · Cited by 137 · see citing works
GAS6 Receptor Status Is Associated with Dormancy and Bone Metastatic Tumor Formation
Taichman, R. S., Patel, L. R., Bedenis, R., Wang, J., Weidner, S., Schumann, T., Yumoto, K., Berry, J. E., Shiozawa, Y., & Pienta, K. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061873 · Cited by 133 · see citing works
Martelli, A. M., Evangelisti, C., Chiarini, F., Grimaldi, C., Cappellini, A., Ognibene, A., & McCubrey, J. A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.04.005 · Cited by 132 · see citing works
The role of Smad signaling in hematopoiesis and translational hematology
Blank, U., & Karlsson, S. (2011) · Leukemia · doi:10.1038/leu.2011.95 · Cited by 130 · see citing works
Lung Stem Cell Self-Renewal Relies on BMI1-Dependent Control of Expression at Imprinted Loci
Zacharek, S. J., Brainson, C. F., Lau, A. N., Gludish, D. W., Chou, A. Y., Ho, J. W. K., Zamponi, R., Gazit, R., Bock, C., Jäger, N., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.07.007 · Cited by 129 · see citing works
Stem cells and aging in the hematopoietic system
Warren, L. A., & Rossi, D. J. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.010 · Cited by 128 · see citing works
Hematopoietic Stem Cell Responsiveness to Exogenous Signals Is Limited by Caspase-3
Janzen, V., Fleming, H. E., Riedt, T., Karlsson, G., Riese, M. J., Celso, C. L., Reynolds, G., Milne, C. D., Paige, C. J., Karlsson, S., et al. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.03.012 · Cited by 125 · see citing works
Cell fate decisions: emerging roles for metabolic signals and cell morphology
Tatapudy, S., Aloisio, F. M., Barber, D. L., & Nystul, T. G. (2017) · EMBO Reports · doi:10.15252/embr.201744816 · Cited by 123 · see citing works
Wang, Z., Li, G., Tse, W., & Bunting, K. D. (2009) · Blood · doi:10.1182/blood-2008-09-181107 · Cited by 118 · see citing works
The bad seed: Cancer stem cells in tumor development and resistance
Koren, E., & Fuchs, Y. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.06.006 · Cited by 109 · see citing works
Neural cell adhesion molecule (NCAM) marks adult myogenic cells committed to differentiation
Capkovic, K. L., Stevenson, S. E., Johnson, M. C., Thelen, J. J., & Cornelison, D. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.01.021 · Cited by 109 · see citing works
Functional characterization of hematopoietic stem cells in the spleen
Morita, Y., Iseki, A., Okamura, S., Suzuki, S., Nakauchi, H., & Ema, H. (2010) · Experimental Hematology · doi:10.1016/j.exphem.2010.12.008 · Cited by 106 · see citing works
Self-citationKang, J. X., Wan, J., & He, C. (2013) · Stem Cells · doi:10.1002/stem.1620 · Cited by 101 · see citing works
Enrichment and Clonal Culture of Progenitor Cells During Mouse Postnatal Liver Development in Mice
Kamiya, A., Kakinuma, S., Yamazaki, Y., & Nakauchi, H. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.001 · Cited by 99 · see citing works
Self-citationTranscriptome Analysis Identifies Regulators of Hematopoietic Stem and Progenitor Cells
Gazit, R., Garrison, B. S., Rao, T. N., Shay, T., Costello, J. C., Ericson, J., Kim, F., Collins, J. J., Regev, A., Wagers, A. J., et al. (2013) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.07.004 · Cited by 99 · see citing works
Extracellular vesicles in the hematopoietic microenvironment
Butler, J. T., Abdelhamed, S., & Kurre, P. (2018) · Haematologica · doi:10.3324/haematol.2017.183335 · Cited by 97 · see citing works
Lipid Mediated Regulation of Adult Stem Cell Behavior
Clémot, M., Demarco, R. S., & Jones, D. L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00115 · Cited by 94 · see citing works
TGFβ restores hematopoietic homeostasis after myelosuppressive chemotherapy
Brenet, F. A., Kermani, P., Spektor, R., Rafii, S., & Scandura, J. M. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121610 · Cited by 96 · see citing works
Warr, M. R., Pietras, E. M., & Passegué, E. (2011) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.145 · Cited by 112 · see citing works
Kustikova, O., Geiger, H., Li, Z.-X., Brugman, M., Chambers, S. M., Shaw, C. A., Pike-Overzet, K., de Ridder, D., Staal, F., von Keudell, G., et al. (2007) · Blood · doi:10.1182/blood-2006-08-044156 · Cited by 22 · see citing works
HOXB4's road map to stem cell expansion
Schiedlmeier, B., SANTOS, A. C. D. S., Ribeiro, A., Moncaut, N., Lesinski, D. A., Auer, H., Kornacker, K., Ostertag, W., Baum, C., Mallo, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703082104 · Cited by 89 · see citing works
Lipid Rafts and Caveolae in Signaling by Growth Factor Receptors
Laurentiis, A. D., Donovan, L., & Arcaro, A. (2007) · The Open Biochemistry Journal · doi:10.2174/1874091x00701010012 · Cited by 83 · see citing works
Pérez-Campo, F. M., Costa, G., Lie‐A‐Ling, M., Stifani, S., Kouskoff, V., & Lacaud, G. (2013) · Stem Cells · doi:10.1002/stem.1606 · Cited by 81 · see citing works
Stampone, E., Caldarelli, I., Zullo, A., Bencivenga, D., Mancini, F. P., Ragione, F. D., & Borriello, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041055 · Cited by 80 · see citing works
Miyamoto, K., Miyamoto, T. K., Kato, R., Yoshimura, A., Motoyama, N., & Suda, T. (2008) · Blood · doi:10.1182/blood-2008-05-159848 · Cited by 79 · see citing works
Altrock, E., Muth, C. A., Klein, G., Spatz, J. P., & Lee‐Thedieck, C. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.002 · Cited by 78 · see citing works
Ratajczak, M. Z., & Adamiak, M. (2015) · Leukemia · doi:10.1038/leu.2015.66 · Cited by 76 · see citing works
Cell cycle regulation of hematopoietic stem or progenitor cells
Hao, S., Chen, C., & Cheng, T. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-1984-4 · Cited by 71 · see citing works
Niche Regulation of Hematopoietic Stem Cells in the Endosteum
Arai, F., Yoshihara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., & Suda, T. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04561.x · Cited by 72 · see citing works
Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells
Quéré, R., Saint-Paul, L., Carmignac, V., Martin, R. Z., Chrétien, M., Largeot, A., Hammann, A., de Barros, J.-P. P., Bastie, J.-N., & Delva, L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405546111 · Cited by 71 · see citing works
An update on Schwann cell biology — Immunomodulation, neural regulation and other surprises
Armati, P. J., & Mathey, E. K. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.01.018 · Cited by 71 · see citing works
Hematopoietic Stem Cells: Transcriptional Regulation, Ex Vivo Expansion and Clinical Application
Aggarwal, R., Lu, J., Pompili, V. J., & Das, H. (2011) · Current Molecular Medicine · doi:10.2174/156652412798376125 · Cited by 68 · see citing works
Hermetet, F., Buffière, A., Aznague, A., de Barros, J.-P. P., Bastie, J.-N., Delva, L., & Quéré, R. (2019) · Nature Communications · doi:10.1038/s41467-018-08228-0 · Cited by 70 · see citing works
Blum, R., Gupta, R., Burger, P. E., Ontiveros, C. S., Salm, S. N., Xiong, X., Kamb, A., Wesche, H., Marshall, L., Cutler, G., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005722 · Cited by 67 · see citing works
Comorbidities of HIV infection
Sviridov, D., Mukhamedova, N., Makarov, A. А., Adzhubei, A. A., & Bukrinsky, M. (2019) · AIDS · doi:10.1097/qad.0000000000002385 · Cited by 66 · see citing works
Maintenance of genomic integrity in hematopoietic stem cells
Naka, K., & Hirao, A. (2011) · International Journal of Hematology · doi:10.1007/s12185-011-0793-z · Cited by 64 · see citing works
Nitta, E., Yamashita, M., Hosokawa, K., Xian, M., Takubo, K., Arai, F., Nakada, S., & Suda, T. (2011) · Blood · doi:10.1182/blood-2010-08-297390 · Cited by 63 · see citing works
Gimeno, M. L., Fuertes, F., Tabarrozzi, A. E. B., Attorresi, A. I., Cucchiani, R., Corrales, L., Oliveira, T. C., Sogayar, M. C., Labriola, L., Dewey, R. A., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2016-0014 · Cited by 65 · see citing works
Liu, Y., Liu, F., Yu, H., Zhao, X., Sashida, G., DeBlasio, A., Harr, M. W., She, Q., Chen, Z., Lin, H., et al. (2012) · Science Signaling · doi:10.1126/scisignal.2003199 · Cited by 62 · see citing works
Current insights into the bone marrow niche: From biology in vivo to bioengineering ex vivo
Xiao, Y., McGuinness, C. S., Doherty-Boyd, W. S., Salmerón‐Sánchez, M., Donnelly, H., & Dalby, M. J. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121568 · Cited by 59 · see citing works
Hepatic stem/progenitor cells and stem-cell transplantation for the treatment of liver disease
Kakinuma, S., Nakauchi, H., & Watanabe, M. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-008-2297-z · Cited by 60 · see citing works
Self-citationSHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-β signaling
Jiang, L., Han, X., Wang, J., Wang, C., Sun, X., Xie, J., Wu, G., Phan, H., Liu, Z., Yeh, E. T. H., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20171477 · Cited by 60 · see citing works
Lin, K. K., Rossi, L., Boles, N. C., Hall, B. E., George, T. C., & Goodell, M. A. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001148 · Cited by 59 · see citing works
Breaking the Cell Cycle of HSCs by p57 and Friends
Tesio, M., & Trumpp, A. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.08.005 · Cited by 57 · see citing works
Regulation of self‐renewal in normal and cancer stem cells
Falzacappa, M. V. V., Ronchini, C., Reavie, L. B., & Pelicci, P. G. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08727.x · Cited by 56 · see citing works
Yanagisawa, M. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0358-1 · Cited by 52 · see citing works
Capitano, M. L., Hangoc, G., Cooper, S. H., & Broxmeyer, H. E. (2015) · Stem Cells · doi:10.1002/stem.1988 · Cited by 51 · see citing works
Differential DNA Damage Response in Stem and Progenitor Cells
Seita, J., Rossi, D. J., & Weissman, I. L. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.006 · Cited by 51 · see citing works
Roy, A., & Patra, S. K. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10448-3 · Cited by 50 · see citing works
Anjos‐Afonso, F., & Bonnet, D. A. (2023) · Blood · doi:10.1182/blood.2022018071 · Cited by 50 · see citing works
- Authors
- Yamazaki, S., Iwama, A., Takayanagi, S., Morita, Y., Eto, K., Ema, H., & Nakauchi, H.
- Affiliations
- Institute of Medical Science, The University of Tokyo (JP)
- Chiba University (JP)
- Corresponding author
- Nakauchi, Hiromitsu
- ORCID
- Venue
- The EMBO Journal
- Published
- 2006-07-20
- Volume
- 25
- Issue
- 15
- Pages
- 3515-3523
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC1538571
- OpenAlex
- W2125723206
- Cited by
- 270
- References
- 33
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 11 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 9 · 2016: 18 · 2015: 14 · 2014: 17 · 2013: 22 · 2012: 17
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- hematopoietic stem cells, lipid rafts, cell cycle re-entry, p57KIP2, cytokine signaling, bone marrow microenvironment, apoptosis, dauer formation, Caenorhabditis elegans
- MeSH terms
- Animals, Cell Cycle, Cells, Cultured, Fluorescent Antibody Technique, Hematopoietic Stem Cells, Mice, Inbred C57BL, Stem Cells, Signal Transduction, Cytokines, Caenorhabditis elegans, Apoptosis, Membrane Microdomains, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review