The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth
Open accessAbstract
Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus promoting GBM malignant growth through PTN–PTPRZ1 paracrine signalling. PTN expression correlates with infiltration of CD11b+/CD163+ TAMs and poor prognosis of GBM patients. Co-implantation of M2-like macrophages (MLCs) promoted GSC-driven tumour growth, but silencing PTN expression in MLCs mitigated their pro-tumorigenic activity. The PTN receptor PTPRZ1 is preferentially expressed in GSCs and also predicts GBM poor prognosis. Disrupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential. Moreover, blocking the PTN–PTPRZ1 signalling by shRNA or anti-PTPRZ1 antibody potently suppressed GBM tumour growth and prolonged animal survival. Our study uncovered a critical molecular crosstalk between TAMs and GSCs through the PTN–PTPRZ1 paracrine signalling to support GBM malignant growth, indicating that targeting this signalling axis may have therapeutic potential.
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Metadata
- Authors
- Shi, Y., Ping, Y.-F., Zhou, W., He, Z.-C., Chen, C., Bian, B.-S.-J., Zhang, L., Chen, L., Lan, X., Zhang, X.-C., Zhou, K., Liu, Q., Long, H., Fu, T.-W., Zhang, X.-N., Cao, M.-F., Huang, Z., Fang, X., Wang, X., Feng, H., Yao, X.-H., Yu, S.-C., Cui, Y.-H., Zhang, X., Rich, J. N., Bao, S., & Bian, X.-W.
- Venue
- Nature Communications
- Published
- 2017-06-01
- Volume
- 8
- Issue
- 1
- Pages
- 15080-15080
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2620943949
- Cited by
- 344
- References
- 67
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- gold
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- Shi, Y., Ping, Y.-F., Zhou, W., He, Z.-C., Chen, C., Bian, B.-S.-J., Zhang, L., Chen, L., Lan, X., Zhang, X.-C., Zhou, K., Liu, Q., Long, H., Fu, T.-W., Zhang, X.-N., Cao, M.-F., Huang, Z., Fang, X., Wang, X., . . . Bian, X.-W. (2017). Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth. Nature Communications. https://doi.org/10.1038/ncomms15080
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
