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Cited by 266

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer

Open access
Chen, Chien-Yu, Jan, Yi-Hua, Juan, Yi-Hsiu, Yang, Chih-Jen, Huang, Ming-Shyan, Yu, Chong-Jen, Yang, Pan-Chyr, Hsiao, Michael, Hsu, Tsui-Ling, Wong, Chi-Huey·2013·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1220425110
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Abstract

The up-regulation of fucosyltransferase 8 (FUT8), the only enzyme catalyzing α1,6-fucosylation in mammals, has been observed in several malignant cancers including liver, ovarian, thyroid, and colorectal cancers. However, the pathological role and the regulatory mechanism of FUT8 in cancers remain largely unknown. In the current study, we report that the expression of FUT8 is up-regulated in nonsmall cell lung cancer (NSCLC) and correlates with tumor metastasis, disease recurrence, and poor survival in patients with NSCLC. Knocking down FUT8 in aggressive lung cancer cell lines significantly inhibits their malignant behaviors including in vitro invasion and cell proliferation, as well as in vivo metastasis and tumor growth. The results of glycoproteomic and microarray analyses show that FUT8 globally modifies surface antigens, receptors, and adhesion molecules and is involved in the regulation of dozens of genes associated with malignancy, suggesting that FUT8 contributes to tumor progression through multiple mechanisms. Moreover, we show that FUT8 is up-regulated during epithelial–mesenchymal transition (EMT), a critical process for malignant transformation of tumor, via the transactivation of β-catenin/lymphoid enhancer-binding factor-1 (LEF-1). These results provide a model to illustrate the relation between FUT8 expression and lung cancer progression and point to a promising direction for the prognosis and therapy of lung cancer.

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Metadata

Authors
Chen, C.-Y., Jan, Y.-H., Juan, Y.-H., Yang, C.-J., Huang, M.-S., Yu, C.-J., Yang, P.-C., Hsiao, M., Hsu, T.-L., & Wong, C.-H.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2012-12-24
Volume
110
Issue
2
Pages
630-635
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1220425110
OpenAlex
W1969135135
Cited by
266
References
32
FWCI
4.07
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer. https://app.cochat.ai/papers/10.1073/pnas.1220425110
The paper
Chen, C.-Y., Jan, Y.-H., Juan, Y.-H., Yang, C.-J., Huang, M.-S., Yu, C.-J., Yang, P.-C., Hsiao, M., Hsu, T.-L., & Wong, C.-H. (2013). Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1220425110

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.